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Triple-chamber bag packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof

A technology of glucose injection and injection, which is applied in the field of medicine, can solve problems such as abnormal fatty acid composition, unbalanced formation of eicosanoid derivatives, and increased lipid peroxidation, so as to achieve stable oil particles, no phase separation, and stable good sex effect

Active Publication Date: 2016-08-03
LIAONING HAISCO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] On the other hand, because the long-chain fat emulsion derived from soybean oil can provide excessive polyunsaturated fatty acids (PUFA), resulting in abnormal fatty acid composition, increasing lipid peroxidation, and causing an imbalance in the formation of eicosanoid derivatives

Method used

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  • Triple-chamber bag packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof
  • Triple-chamber bag packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof
  • Triple-chamber bag packaged olive oil, amino acid and glucose injection pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0044] The preparation of the olive oil fat emulsion, compound amino acid and glucose injection of embodiment 1 three-cavity bag packing

[0045] Olive oil fat emulsion injection prescription:

[0046]

[0047] Compound amino acid injection prescription:

[0048]

[0049]

[0050] Glucose Injection Prescription:

[0051] Glucose 122.10g (or monohydrate glucose 134.10g),

[0052] Add water for injection to a total volume of 1L.

[0053] The preparation method is prepared according to the following steps:

[0054] Step 1, bag making:

[0055] Take the plastic film for the inner bag, press it on the bag making hot press and connect it to the filling port;

[0056] Take the plastic film for the outer bag, press it on the bag-making hot press, and leave one side open;

[0057] Step 2, dosing:

[0058] a. Preparation of olive oil fat emulsion injection:

[0059] Under nitrogen protection, weigh the prescribed amount of olive oil for injection and soybean oil for injec...

Embodiment 2 3

[0073] The preparation of the olive oil fat emulsion, compound amino acid and glucose injection of embodiment 2 three-cavity bag packing

[0074] Olive oil fat emulsion injection prescription:

[0075]

[0076] Compound amino acid injection prescription:

[0077]

[0078]

[0079] Glucose Injection Prescription:

[0080] Glucose 187.10g (or glucose monohydrate 205.82g),

[0081] Add water for injection to a total volume of 1L.

[0082] The preparation method is the same as in Example 1.

Embodiment 3 3

[0083] Preparation of olive oil fat emulsion, compound amino acid and glucose injection in embodiment 3 three-chamber bag packaging

[0084] Olive oil fat emulsion injection prescription:

[0085]

[0086] Compound amino acid injection prescription:

[0087]

[0088]

[0089] Glucose Injection Prescription:

[0090] Glucose 227.78g (or glucose monohydrate 250.56g),

[0091] Add water for injection to a total volume of 1L.

[0092] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to a triple-chamber bag packaged olive oil, amino acid and glucose injection pharmaceutical composition and its preparation method, and belongs to the field of medical technology. Three spaced chambers of a triple-chamber bag are respectively filled with an olive oil fat emulsion injection, a compound amino acid injection and a glucose injection. Before clinical infusion, the triple-chamber bag can be extruded to mix the components in the chambers. The product is convenient to use. There is no special requirement on the environment, and the risk of microbe and particulate pollution which is easily caused by a traditional mixing operation method is avoided.

Description

technical field [0001] The invention relates to a pharmaceutical composition of olive oil fat emulsion, compound amino acid and glucose injection packaged in a three-cavity bag and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Fat, protein and sugar are the three types of basic nutrients that the human body needs the most. When the human gastrointestinal tract is insufficient or cannot absorb enough of the above nutrients, it must be provided in the form of intravenous infusion. Therefore, fat emulsion injection, compound amino acid injection and glucose injection are widely used clinically to provide fat, protein and sugar respectively, which is the so-called parenteral nutrition. [0003] Both theory and practice have proved that when long-term use of parenteral nutrition is required, intravenous infusion of fat emulsion, amino acids and glucose into the human body at the same time is most in line with the physiol...

Claims

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Application Information

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IPC IPC(8): A61K36/32A61K31/7004A61K9/00A61P3/02A61K31/22A61K31/198
Inventor 陶建林蒋涛余悦东冯卫左玲玲
Owner LIAONING HAISCO PHARMACEUTICAL CO LTD