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Immunogenic Anti-inflammatory compositions

A technology of inflammation and medicine, applied in the field of immunogenic anti-inflammatory composition, can solve problems such as incompleteness

Active Publication Date: 2016-08-03
QU BIOLOGICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The understanding of inflammatory bowel disease is developing but in many ways incomplete (see, for example, BaumgartDC, CardingSR (2007) "Inflammatoryboweldisease: causeandimmunobiology"TheLancet369(9573):1627–40; BaumgartDC, SandbornWJ (2007) "Inflammatoryboweldisease: clinicalaspectsandestablishedandevolvingtherapies"TheLancet369(9573):1641–57;XavierRJ,PodolskyDK(2007)"Unravellingthepathogenesisofinflammatoryboweldisease"Nature448(7152):427–34;J.H.Cho(2008)"Thegeneticsandimmunopathogenesisofinflammatoryboweldisease"NatureReviewsImmunology8,458-466)

Method used

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  • Immunogenic Anti-inflammatory compositions
  • Immunogenic Anti-inflammatory compositions
  • Immunogenic Anti-inflammatory compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0358] Example 1: Clinical Research

[0359] bacterial composition

[0360] Five killed bacterial compositions have been used to treat a wide range of cancer types and stages in studies blinded to participants, as follows:

[0361] 1. Bayer Corporation MRV TM "Bayer MRV" (Hollister-Steir Laboratories, Spokane, WA, U.S.A.), comprising the following bacterial species:

[0362]

[0363] The vaccine is prepared for the following indications: rhinitis, infectious asthma, chronic sinusitis, nasal polyps, and chronic serous otitis media. The treatment of cancer is not indicated as the intended use of this vaccine. The vaccine also included the following ingredients: 0.4% phenol, 0.9% NaCl, traces of brain heart infusion (bovine), peptone, yeast extract, sheep blood, dextrose, and sodium phosphate.

[0364] 2. Stallergenes MRV "Stallergenes MRV" (Laboratories des Stallergenes, S.A., Fresnes, France), including the following:

[0365]

[0366] This vaccine was prepared for...

Embodiment 1A

[0383] Example 1A: Cancer of the Lung

[0384] This section deals with primary cancers in the lungs or metastases to the lungs that are treated by microbial pathogens in the lungs, such as endogenous respiratory bacterial flora.

[0385] Patients were eligible for lung cancer studies if they were initially diagnosed with stage 3B or 4 (inoperable) cancer. Lung cancer staging is performed using standard methods such as in AJCC: Cancer Staging Handbook (6th Edition) 2002; Springer-Verlag New York: Editors: Fredrick Greene, David Page and Irvin Fleming, or in International Union Against Cancer: TNM Classification of Malignant Tumors (6th Edition) 2002; Wiley-LissGenevaSwitzerland: Editors : described in L.H.Sobin and C.H.Wittekind. For example, lung cancer can be classified as follows:

[0386] TNM pulmonary clinical and pathological classification

[0387] T primary tumor

[0388] Unable to evaluate primary tumor, or tumor by flushing in saliva or bronchi

[0389] The pre...

Embodiment 1B

[0427] Example 1B: Breast cancer with metastases to bone or lung

[0428] The most common cause of breast and bone infections is Staphylococcus aureus. Thus, in one aspect of the invention, an antigenic composition comprising an antigenic determinant of S. aureus can be used for the treatment of breast cancer with metastases to the bone. The remarkable case of Patient R (PtR) treated with the S. aureus vaccine shown in the case report below demonstrates the efficacy of this approach for the treatment of breast cancer with bone metastases. like Image 6 As shown, in some cumulative 52 patients, the survival of breast cancer patients with bone and / or lung metastases with MRV containing Staphylococcus aureus (n=19) was better than that without MRV vaccine (n=19). 33) Survival of treated patients:

[0429]

[0430] Based on the foregoing results, one aspect of the present invention includes the treatment of primary cancer in the mammary gland or metastasis to the mammary gla...

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Abstract

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.

Description

field of invention [0001] In various aspects, the invention relates to immunological therapies for the treatment of disease states characterized by inflammation. In alternative embodiments, the present invention provides methods of formulating antigenic compositions for use in the treatment of inflammatory disease states. Background of the invention [0002] More than one third of the population in developed countries is diagnosed with cancer. More than a quarter of people die from it. Therapies for cancer rely primarily on treatments such as surgery, chemotherapy and radiation. However, while these approaches are beneficial for certain types and stages of cancer, they have proven to have limited efficacy in many common types and stages of cancer. For example, surgical treatment of tumors requires complete removal of cancerous tissue to prevent recurrence. Likewise, radiation therapy requires the complete destruction of cancer cells. This is difficult because, in theory...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61K39/02A61K39/002A61K39/12A61P31/04A61P29/00A61P1/00A61P35/00
CPCA61K33/24A61K39/00A61K39/0002A61K39/0008A61K39/0011A61K39/002A61K39/02A61K39/0258A61K39/0266A61K39/05A61K39/085A61K39/092A61K39/102A61K39/12A61K2039/521A61K2039/5252A61K2039/54A61K2039/542A61K2039/545A61K2039/58A61K2039/585A61K2039/70A61K2300/00Y02A50/30
Inventor 哈罗尔·戴维·贡萨利姆·丹吉
Owner QU BIOLOGICS INC
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