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Immunogenic anti-inflammatory composition

An anti-inflammatory composition, a technology of species, applied in the field of antigen composition for the treatment of inflammatory disease states, and the field of immunotherapy of disease states, which can solve problems such as incompleteness

Active Publication Date: 2020-03-06
QU BIOLOGICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The understanding of inflammatory bowel disease is developing but in many ways incomplete (see, for example, Baumgart DC, Carding SR (2007) "Inflammatory bowel disease: cause and immunobiology" The Lancet 369(9573):1627–40; Baumgart DC, Sandborn WJ (2007) "Inflammatory bowel disease: clinical aspects and established and evolving therapies" The Lancet 369 (9573): 1641–57; Xavier RJ, Podolsky DK (2007) "Unravelling the pathogenesis of inflammatory bowel disease" Nature 448): 4272 –34; J.H.Cho (2008) "The genetics and immunopathogenesis of inflammatory bowel disease" Nature Reviews Immunology 8, 458-466)

Method used

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  • Immunogenic anti-inflammatory composition
  • Immunogenic anti-inflammatory composition
  • Immunogenic anti-inflammatory composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0363] Example 1: Clinical study

[0364] Bacterial composition

[0365] In a study unknown to the participants, five killer bacterial compositions have been used to treat a wide range of cancer types and stages, as follows:

[0366] 1.Bayer Corporation MRV TM "Bayer MRV" (Hollister-Steir Laboratories, Spokane, WA, U.S.A.) contains the following bacterial species:

[0367]

[0368] The vaccine is prepared for the following indications: rhinitis, infectious asthma, chronic sinusitis, nasal polyps and chronic serous otitis media. The treatment of cancer is not indicated as the intended use of the vaccine. The vaccine also includes the following ingredients: 0.4% phenol, 0.9% NaCl, trace amounts of brain heart infusion (bovine), peptone, yeast extract, sheep blood, dextrose and sodium phosphate.

[0369] 2. Stallergenes MRV "Stallergenes MRV" (Laboratories des Stallergenes, S.A., Fresnes, France), including the following:

[0370]

[0371] The vaccine is prepared for the same indications...

Embodiment 1A

[0388] Example 1A: Cancer of the lung

[0389] This part relates to primary cancers in the lungs or metastasis to the lungs, which are treated by microbial pathogens in the lungs, such as endogenous respiratory bacterial flora.

[0390] If patients are initially diagnosed with stage 3B or 4 (not suitable for surgery) cancer, they are suitable for lung cancer research. Lung cancer staging is performed using standard methods, such as in AJCC: Cancer Staging Handbook (6th Edition) 2002; Springer-Verlag New York: Editors: Fredrick Greene, David Page and Irvin Fleming, or in International Union Against Cancer: TNM Classification of Malignant Tumors (6th edition) 2002; Wiley-Liss Geneva Switzerland: Editors: LHSobin and C.H. Wittekind. For example, lung cancer can be classified as follows:

[0391] TNM lung clinical and pathological classification

[0392]

[0393]

[0394] Stage classification of TNM subtypes

[0395]

[0396]

[0397] Manually and electronically collect charts with dia...

Embodiment 1B

[0414] Example 1B: Breast cancer with metastasis to bone or lung

[0415] The most common cause of breast infection and bone infection is Staphylococcus aureus. Therefore, in one aspect of the present invention, the antigenic composition containing the antigenic determinants of Staphylococcus aureus can be used to treat breast cancer with bone metastasis. The significant case of patient R (PtR) treated with Staphylococcus aureus vaccine shown in the following case report shows the effectiveness of this method for treating breast cancer with bone metastases. Such as Image 6 As shown, in some cumulative 52 patients, breast cancer patients with metastasis to bone and / or lung with MRV containing Staphylococcus aureus (n=19) survived better than those without MRV vaccine (n= 33) Survival of treated patients:

[0416]

[0417] Based on the foregoing results, one aspect of the present invention includes the use of an antigen composition containing antigenic determinants of microorganis...

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Abstract

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.

Description

[0001] Invention field [0002] In various aspects, the present invention relates to immunological therapy for the treatment of disease states characterized by inflammation. In an alternative embodiment, the invention provides a method of formulating an antigen composition for the treatment of an inflammatory disease state. [0003] Background of the invention [0004] More than one-third of the population in developed countries is diagnosed with cancer. More than a quarter of people died because of it. Therapies for cancer mainly rely on treatments such as surgery, chemotherapy, and radiation. However, although these methods are beneficial for certain types and stages of cancer, they have proven to have limited efficacy in many common types and stages of cancer. For example, surgical treatment of tumors requires complete removal of cancerous tissue to prevent recurrence. Similarly, radiation therapy requires complete destruction of cancer cells. This is difficult because, in th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/00A61K39/02A61K39/002A61K39/12A61P31/04A61P29/00A61P1/00A61P35/00
CPCA61K33/24A61K39/00A61K39/0002A61K39/0008A61K39/0011A61K39/002A61K39/02A61K39/0258A61K39/0266A61K39/05A61K39/085A61K39/092A61K39/102A61K39/12A61K2039/521A61K2039/5252A61K2039/54A61K2039/542A61K2039/545A61K2039/58A61K2039/585A61K2039/70A61K2300/00Y02A50/30
Inventor 哈罗尔·戴维·贡萨利姆·丹吉
Owner QU BIOLOGICS INC