Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of multifunctional nano medicine composition and its preparation method and application

A nano-medicine and multi-functional technology, applied in the direction of drug combination, pharmaceutical formula, anti-tumor drugs, etc., can solve the problems of side effects, drug utilization reduction, etc., achieve high drug loading, improve treatment efficiency, and narrow distribution effect

Active Publication Date: 2020-08-21
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nanomicelle drug carriers have a common problem, that is, the drug release process, that is, in the drug release process, about 30% of the drug will be released in the first 8 hours, and the drug carrier injected intravenously is in the body at this time The blood circulates and is not enriched in a large amount in the tumor tissue, which will lead to a decrease in drug availability and certain side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of multifunctional nano medicine composition and its preparation method and application
  • A kind of multifunctional nano medicine composition and its preparation method and application
  • A kind of multifunctional nano medicine composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 20mg of P(MEO 2 MA-co-OEGMA-co-DMAEMA)-b-PLGA) was dissolved in 1mL of dichloromethane, 0.2mL of doxorubicin hydrochloride aqueous solution (7.5mg / mL) was added, after mixing, it was sonicated for 3min, and then 2mL of 2% mass concentration was added Vortex and mix well, add 0.2mL of docetaxel (5mg / mL) dissolved in dichloromethane, and after ultrasonic emulsification for 8min, slowly add the mixture into 10mL of 0.3% polyvinyl alcohol and stir 10min. Evaporate under reduced pressure with a rotary evaporator to remove dichloromethane in the solution, centrifuge at 13,000 rpm for 10 min, then centrifuge with deionized water, and wash. 100 mg of the above-obtained nanomicelles (ie, the result after washing) were added to a Tris buffer solution with a pH of 8.5, and the concentration of Tris after the addition was 10 mmol / L. Add 50 mg of dopamine, react for 24 hours, and centrifuge at 60,000 rpm to obtain a multifunctional nano drug composition. Among them, P(MEO 2 The ...

Embodiment 2

[0046] 20mg of P(MEO 2 MA-co-OEGMA-co-DMAEMA)-b-PLGA) was dissolved in 1 mL of dichloromethane, 0.2 mL of doxorubicin hydrochloride aqueous solution (5 mg / mL) was added, after mixing, it was sonicated for 5 min, and then 10 mL of 2% mass concentration was added Aqueous polyvinyl alcohol solution, vortex and mix evenly, add 0.2mL of docetaxel (5mg / mL) dissolved in dichloromethane, then ultrasonic emulsification for 8min, evaporate under reduced pressure with a rotary evaporator to remove dichloromethane in the solution Afterwards, centrifuge at 13000rpm for 10min, and then wash with deionized water. 100 mg of the nanomicelles obtained above (ie, the product after washing) were added to a Tris buffer solution with a pH of 7.5, and the concentration of Tris after addition was 1 mmol / L. Add 10 mg of dopamine, react for 4 hours, and centrifuge at 10,000 rpm to obtain a multifunctional nanomedicine composition. Among them, P(MEO 2 The weight-average molecular weight of MA-co-OEGM...

Embodiment 3

[0048] 20mg of P(MEO 2 MA-co-OEGMA-co-DMAEMA)-b-PLGA) was dissolved in 1mL of ethyl acetate, 0.2mL of doxorubicin hydrochloride aqueous solution (5mg / mL) was added, after mixing, it was sonicated for 5min, and then 10mL of 2% mass concentration Polyvinyl alcohol and 10 mL of propylene glycol block polyether F68 aqueous solution with a mass concentration of 2% were mixed evenly by vortexing, and 0.2 mL of docetaxel (1 mg / mL) dissolved in dichloromethane was added, and after ultrasonic emulsification for 8 min, the solution was evaporated by rotary evaporation After vacuum evaporation and removal of dichloromethane in the solution, centrifuge at 13,000 rpm for 10 min, and then centrifuge and wash with deionized water. 10 mg of the nanomicelles obtained above (ie, the result after washing) were added to a Tris buffer solution with a pH of 10.5, and the concentration of Tris after the addition was 20 mmol / L. Then add 100 mg of dopamine, react for 48 hours, and then centrifuge at ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
sizeaaaaaaaaaa
molecular weightaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention provides a multifunctional nano-medicinal composition, as well as a preparation method and application thereof. The composition comprises a carrier and an active ingredient loaded on the carrier, wherein the carrier is nano-particles which are prepared by adsorbing polydopamine to the nano-micelle surface form by poly(2-methyl-2-acrylic acid-2-(2-methoxyethoxy-ethyl-co-oligo(ethylene glycol) methyl ether methacrylate-co-dimethylaminoethyl methacrylate-poly(lactate-co-glycolic acid) segmented copolymer; the active ingredient comprises a hydrophobic drug and hydrophilic drug. The multifunctional nano-medicinal composition has a size of 50-1000nm, and has a drug constant-release effect, can be combined with chemotherapy to improve the treatment efficiency since polydopamine has a photothermal therapy effect, and can be applied to tumor treatment medicines.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, and in particular relates to a multifunctional nano-medicine composition and a preparation method and application thereof. Background technique [0002] Nano-drug delivery system refers to the drug delivery system formed by drugs and nano-carriers with a particle size ranging from 1-1000nm, including nanospheres, nanocapsules, nanoparticles and nanoliposomes. Compared with other drug carriers, the nano-drug delivery system has significant advantages: (1) ultra-small volume, which can pass through the smallest capillaries in the human body, and is not easily cleared by phagocytic cells, prolonging the residence time in the circulatory system; (2) ) reach target sites such as the liver, spleen, lung, bone marrow, and lymph where the reticuloendothelial system is concentrated; (3) can penetrate the interstitial space and be absorbed by cells, which is conducive to transdermal absorption and intracell...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K9/107A61K47/34A61K31/704A61K31/337A61P35/00
CPCA61K9/1075A61K9/5146A61K31/337A61K31/704A61K41/0052A61K47/34A61K2300/00
Inventor 聂广军吴雁苏世帅
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com