Preparation method of composition containing hyaluronic acid, obtained product and application

The technology of a hyaluronic acid and a composition is applied in the preparation of a composition containing hyaluronic acid, the obtained products and the application fields, and can solve the problems of reduced moisture retention, excellent biocompatibility, complicated preparation process, etc. Wide population, mild use, mild reaction conditions

Active Publication Date: 2016-08-17
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with hyaluronic acid, modified hyaluronic acid (that is, cationic hyaluronic acid) has improved affinity, but its excellent effects such as moisture retention and biocompatibility are reduced, and the reactions are all in stron

Method used

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  • Preparation method of composition containing hyaluronic acid, obtained product and application
  • Preparation method of composition containing hyaluronic acid, obtained product and application
  • Preparation method of composition containing hyaluronic acid, obtained product and application

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0040] Example 1

[0041] Accurately weigh cationic cellulose powder (molecular weight 100000-2000000Da) 4.0kg, cosmetic-grade low-molecular-weight sodium hyaluronate (molecular weight 200000-400000Da) 0.5kg and cosmetic-grade high-molecular-weight sodium hyaluronate (molecular weight 1.600000~2000000Da) 0.5kg, Pour the raw material powder into a 200L emulsification tank, add 12kg of propylene glycol, turn on the mechanical stirring and mix for 0.5h until the raw materials are evenly dispersed in the propylene glycol; add 183L of water to the tank and mechanically stir until the raw materials are completely dissolved and form a uniform solution; The temperature was adjusted to 60℃, the pH was adjusted to 5.5 with 20wt% citric acid solution, and the temperature was kept for 2~5 hours to obtain a light yellow viscous liquid with a certain viscosity. The measured dynamic viscosity was 10000mPa·s, and the viscous liquid was The hyaluronic acid-containing composition can be directly p...

Example Embodiment

[0042] Example 2

[0043] Accurately weigh 1.0kg of cationic guar gum powder (molecular weight 100000~2000000Da) and 5.0kg of cosmetic-grade polymer sodium hyaluronate (molecular weight 1000000~1600000Da), pour the raw material powder into a 200L emulsification tank, add 12kg propylene glycol, and turn on the machine Stir and mix for 0.5h until the raw materials are evenly dispersed in propylene glycol; then add 183L of purified water to the tank and mechanically stir until the raw materials are completely dissolved to form a uniform solution; adjust the temperature in the tank to 60°C, and use 20wt% citric acid solution to adjust the pH Adjust to 5.5, heat preservation reaction for 2~5h, obtain a white gel with certain viscosity, and the measured dynamic viscosity is 250,000mPa·s. This viscous liquid is a composition containing hyaluronic acid, which can be directly packaged and used. Place 3 No stratification was seen in the month.

Example Embodiment

[0044] Example 3

[0045] Accurately weigh 3.0 kg of cationic guar gum powder (molecular weight 100,000-2000000Da) and 3.0 kg of cosmetic-grade polymer sodium hyaluronate (molecular weight 1.600000-2000000Da), pour the raw material powder into a 200L emulsification tank, add 12kg propylene glycol, and turn on the machine Stir and mix for 1 hour until the raw materials are evenly dispersed in propylene glycol; add 183L of water to the tank and mechanically stir until the raw materials are completely dissolved and form a uniform solution; adjust the temperature in the tank to 60°C, and adjust the pH to 5.5 with 20wt% citric acid solution , The heat preservation reaction is 2 to 5 hours, and a white gel with a certain viscosity is obtained. The measured dynamic viscosity is 380,000 mPa·s. The viscous liquid is a composition containing hyaluronic acid, which can be directly packaged for use, and no delamination is seen after being placed for 3 months.

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Abstract

The invention discloses a preparation method of a composition containing hyaluronic acid, an obtained product and application. At least one cationic polymer and at least one molecular hyaluronic acid or salt of hyaluronic acid are mixed and subjected to complexing reaction, reaction is stopped when the system dynamic viscosity is 100-400000 mPa.s, and a mixture obtained through reaction is the composition containing hyaluronic acid. Operation is easy, reaction conditions are mild, the complexing product can be directly used as the composition without alcohol precipitation, separation, purification, washing and other treatment operation, and the product is easier and more convenient and rapid to use. The product has high affinity on viable tissue, can be more easily adsorbed to skin (including scalp) or hair, has functions of moisturizing, nursing and conditioning, can make skin and hair moist and smooth, can be used in daily use chemical articles with skin moisturizing and nursing or hair washing and caring effects and has quite good application prospects.

Description

technical field [0001] The present invention relates to a preparation method of a composition containing hyaluronic acid, and also relates to the composition obtained according to the method and the application of the composition. The composition has high affinity and has great potential in the daily chemical field good application. Background technique [0002] Hyaluronic acid is a mucopolysaccharide widely present in living organisms, and is widely used in cosmetics due to its high moisturizing effect. However, since the surface of hair and skin is usually negatively charged, hyaluronic acid is also usually negatively charged due to its anionic functional groups such as carboxyl groups. Therefore, when hyaluronic acid is used to treat hair or skin, the two repel each other. For this reason, hyaluronic acid is generally difficult to adsorb on the surface of hair and skin. [0003] Cationic polymers are an important class of functional compounds, which are positively charg...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/34A61K8/81A61Q5/02A61Q5/12A61Q19/00
CPCA61K8/345A61K8/731A61K8/735A61K8/737A61K8/817A61K2800/5426A61Q5/02A61Q5/12A61Q19/00
Inventor 冯宁申凤同耿凤石艳丽郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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