Preparation method of composition containing hyaluronic acid, obtained product and application
The technology of a hyaluronic acid and a composition is applied in the preparation of a composition containing hyaluronic acid, the obtained products and the application fields, and can solve the problems of reduced moisture retention, excellent biocompatibility, complicated preparation process, etc. Wide population, mild use, mild reaction conditions
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[0040] Example 1
[0041] Accurately weigh cationic cellulose powder (molecular weight 100000-2000000Da) 4.0kg, cosmetic-grade low-molecular-weight sodium hyaluronate (molecular weight 200000-400000Da) 0.5kg and cosmetic-grade high-molecular-weight sodium hyaluronate (molecular weight 1.600000~2000000Da) 0.5kg, Pour the raw material powder into a 200L emulsification tank, add 12kg of propylene glycol, turn on the mechanical stirring and mix for 0.5h until the raw materials are evenly dispersed in the propylene glycol; add 183L of water to the tank and mechanically stir until the raw materials are completely dissolved and form a uniform solution; The temperature was adjusted to 60℃, the pH was adjusted to 5.5 with 20wt% citric acid solution, and the temperature was kept for 2~5 hours to obtain a light yellow viscous liquid with a certain viscosity. The measured dynamic viscosity was 10000mPa·s, and the viscous liquid was The hyaluronic acid-containing composition can be directly p...
Example Embodiment
[0042] Example 2
[0043] Accurately weigh 1.0kg of cationic guar gum powder (molecular weight 100000~2000000Da) and 5.0kg of cosmetic-grade polymer sodium hyaluronate (molecular weight 1000000~1600000Da), pour the raw material powder into a 200L emulsification tank, add 12kg propylene glycol, and turn on the machine Stir and mix for 0.5h until the raw materials are evenly dispersed in propylene glycol; then add 183L of purified water to the tank and mechanically stir until the raw materials are completely dissolved to form a uniform solution; adjust the temperature in the tank to 60°C, and use 20wt% citric acid solution to adjust the pH Adjust to 5.5, heat preservation reaction for 2~5h, obtain a white gel with certain viscosity, and the measured dynamic viscosity is 250,000mPa·s. This viscous liquid is a composition containing hyaluronic acid, which can be directly packaged and used. Place 3 No stratification was seen in the month.
Example Embodiment
[0044] Example 3
[0045] Accurately weigh 3.0 kg of cationic guar gum powder (molecular weight 100,000-2000000Da) and 3.0 kg of cosmetic-grade polymer sodium hyaluronate (molecular weight 1.600000-2000000Da), pour the raw material powder into a 200L emulsification tank, add 12kg propylene glycol, and turn on the machine Stir and mix for 1 hour until the raw materials are evenly dispersed in propylene glycol; add 183L of water to the tank and mechanically stir until the raw materials are completely dissolved and form a uniform solution; adjust the temperature in the tank to 60°C, and adjust the pH to 5.5 with 20wt% citric acid solution , The heat preservation reaction is 2 to 5 hours, and a white gel with a certain viscosity is obtained. The measured dynamic viscosity is 380,000 mPa·s. The viscous liquid is a composition containing hyaluronic acid, which can be directly packaged for use, and no delamination is seen after being placed for 3 months.
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