Preparation method of composition containing hyaluronic acid, obtained product and application
The technology of a hyaluronic acid and a composition is applied in the preparation of a composition containing hyaluronic acid, the obtained products and the application fields, and can solve the problems of reduced moisture retention, excellent biocompatibility, complicated preparation process, etc. Wide population, mild use, mild reaction conditions
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Embodiment 1
[0041] Accurately weigh 4.0kg of cationic cellulose powder (molecular weight 100000-2000000Da), 0.5kg of cosmetic grade low molecular weight sodium hyaluronate (molecular weight 200000~400000Da) and 0.5kg of cosmetic grade high molecular weight sodium hyaluronate (molecular weight 1600000~2000000Da), Pour the raw material powder into a 200L emulsification tank, add 12kg of propylene glycol, turn on the mechanical stirring and mix for 0.5h until the raw material is evenly dispersed in the propylene glycol; add 183L of water to the tank, and mechanically stir until the raw material is completely dissolved to form a uniform solution; Adjust the temperature to 60°C, adjust the pH to 5.5 with 20wt% citric acid solution, and keep it warm for 2 to 5 hours to obtain a light yellow viscous liquid with a certain viscosity. The measured dynamic viscosity is 10000mPa·s, and the viscous liquid is The composition containing hyaluronic acid can be directly packaged and used, and there is no d...
Embodiment 2
[0043] Accurately weigh 1.0kg of cationic guar gum powder (molecular weight 100000-2000000Da) and 5.0kg of cosmetic grade polymer sodium hyaluronate (molecular weight 1000000-1600000Da), pour the raw material powder into a 200L emulsification tank, add 12kg propylene glycol, and turn on the machine Stir and mix for 0.5h until the raw materials are evenly dispersed in propylene glycol; then add 183L of purified water to the tank, and mechanically stir until the raw materials are completely dissolved to form a uniform solution; adjust the temperature in the tank to 60°C, and adjust the pH Adjust it to 5.5, keep it warm for 2-5 hours, and obtain a white jelly with a certain viscosity. The measured dynamic viscosity is 250,000mPa·s. This viscous liquid is a composition containing hyaluronic acid. It can be directly packaged and used. No stratification was seen in the month.
Embodiment 3
[0045] Accurately weigh 3.0 kg of cationic guar gum powder (molecular weight 100,000-2,000,000 Da) and 3.0 kg of cosmetic-grade polymer sodium hyaluronate (molecular weight 1,600,000-2,000,000 Da), pour the raw material powder into a 200L emulsification tank, add 12 kg of propylene glycol, and turn on the machine Stir and mix for 1 hour until the raw materials are evenly dispersed in propylene glycol; add 183L of water to the tank, and mechanically stir until the raw materials are completely dissolved to form a uniform solution; adjust the temperature in the tank to 60°C, and adjust the pH to 5.5 with 20wt% citric acid solution , Insulated for 2 to 5 hours, a white jelly with a certain viscosity was obtained, and the measured dynamic viscosity was 380000mPa·s. The viscous liquid is the hyaluronic acid-containing composition, which can be directly packaged and used, and there is no delamination after being placed for 3 months.
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