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Water-soluble pachymaran metal complex and preparing method and application thereof

A technology of metal complexes and polysaccharides, applied in food science, drug combination, metabolic diseases, etc., can solve the problems of low bioavailability and poor water solubility of polysaccharides

Inactive Publication Date: 2016-08-17
SYNCOM CHINA CO LTD WUHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, unmodified Poria cocos polysaccharide has poor water solubility and low bioavailability, and it must be properly degraded and derivatized to exert pharmacological activity.

Method used

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  • Water-soluble pachymaran metal complex and preparing method and application thereof
  • Water-soluble pachymaran metal complex and preparing method and application thereof
  • Water-soluble pachymaran metal complex and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Example one: the preparation technology of water-soluble pachyrhythmic polysaccharide iron complex:

[0030] (1) Water-soluble pachyrhin is dissolved in 1mol / L NaOH solution, then the pH is adjusted to 5.5 with hydrochloric acid solution, and compound plant hydrolytic enzyme liquid is added to the resulting mixture, kept in a water bath at 60°C for 6 hours, centrifuged, Alcohol precipitation, washing, and drying, the obtained brown powder is water-soluble pachyrhin;

[0031] (2) Dissolve the water-soluble polysaccharide in deionized water, add 1mol / L ferric chloride solution, adjust the pH to 7.0, keep the temperature at 60°C for 2 hours to form a metal complex, and centrifuge and dialysis bag (COMW 7000Da) dialysis, alcohol precipitation, the precipitate obtained is the crude product, and then through washing and drying, the water-soluble polysaccharide metal complex with certain color is obtained.

[0032] The physical and chemical properties of the obtained product:...

example 2

[0034] Example two: the preparation technology of water-soluble pachyrhythm polysaccharide iron complex.

[0035] (1) Water-soluble polysaccharide is to dissolve polysaccharide in 2mol / L NaOH solution, then adjust the pH to 5.0 with hydrochloric acid solution, add compound plant hydrolytic enzyme liquid to the obtained mixture, keep it warm in a water bath at 60°C for 4 hours, centrifuge, After alcohol precipitation, washing and drying, the obtained brown powder is water-soluble pachyrhin.

[0036] (2) Dissolve the water-soluble polysaccharide in deionized water, add 1mol / L ferric chloride solution, adjust the pH to 6.0, keep the temperature at 80°C for 4 hours to form a metal complex, and centrifuge and dialysis bag (COMW 7000Da) dialysis, alcohol precipitation, the precipitate obtained is the crude product, and then through washing and drying, the water-soluble polysaccharide metal complex with certain color is obtained.

[0037] The physical and chemical properties of the ob...

example 3

[0039] Example 3: The preparation process of water-soluble pachyrhiza-zinc complex.

[0040] (1) Dissolve Poria cocos polysaccharide in 0.5mol / L NaOH solution, then adjust the pH to 4.0 with sulfuric acid solution, add compound plant hydrolytic enzyme solution to the resulting mixture, keep warm in a water bath at 50°C for 5 hours, centrifuge, alcohol precipitation, and wash , drying, the resulting brown powder is the water-soluble pachyrhythm.

[0041] (2) Dissolve the water-soluble polysaccharide in deionized water, add 1mol / L zinc sulfate solution, adjust the pH to 8.0, keep the temperature at 80°C for 3 hours to make a metal complex, centrifuge, dialysis bag ( COMW 7000Da) dialysis, ethanol precipitation, the precipitate obtained is the crude product, and then through washing and drying, the water-soluble pachyrhytha polysaccharide metal complex with a certain color is obtained.

[0042] The physical and chemical properties of the product obtained: the water-soluble polys...

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Abstract

The invention provides a preparing method of a water-soluble pachymaran metal complex. The preparing method comprises the steps that firstly, pachymaran is dissolved in a NaOH solution, then the pH is regulated to be 3.5-5.5 with an acid solution, a composite plant hydrolase solution is added into the mixture, heat preservation is carried out for 4-6 h with a water bath at 50-70 DEG C, centrifuging, alcohol precipitation, washing and drying are carried out, and brown powder, namely, water-soluble pachymaran, is obtained; secondly, the water-soluble pachymaran is dissolved in deionized water, a metal ion solution is added, the pH is regulated to be 6-8, a reaction is carried out for 2-4 h with the temperature maintained at 50-80 DEG C, a metal complex is generated by the mixture, centrifuging, dialyzing and alcohol precipitation are carried out, light brown to brown precipitate, namely, a crude product, is obtained, washing and drying are carried out, and then the water-soluble pachymaran metal complex is obtained. The water-soluble pachymaran metal complex can be widely applied to development of foods, drugs, health-care products and the like to improve the medical and health-care performance of related products and reduce toxic and side effects, and has very wide application prospects.

Description

technical field [0001] The invention relates to a water-soluble polysaccharide metal complex, a preparation method and application thereof. Background technique [0002] Poria, also known as Yuling, Fuling, Wanlinggui, and Poria, is the dry sclerotium of the fungus Poria cocos of the family Phytoporaceae, often parasitic on the roots of pine trees, shaped like a sweet potato, spherical, light brown or dark brown on the outside, and inside Pink or white, it is called Bai Fu Ling or Yun Ling after refining. Poria cocos polysaccharide (pachyman) is mainly composed of -(1→3)-D-glucan, which is the main chemical component in Poria cocos, and its content can reach 84% of the dry weight of Poria cocos. As a traditional Chinese medicine in my country, Poria cocos ranks among the "four monarchs and eight treasures" of traditional Chinese medicine. It has a wide range of uses and a large dosage. Modern medical research has proved that Poria cocos polysaccharide has pharmacological ef...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P35/00A61P3/02A23L33/165
CPCC08B37/00
Inventor 张柯达胡先明曹袆卉肖玉玲陈铭刘鹏
Owner SYNCOM CHINA CO LTD WUHAN
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