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Biocompatible carbon nanotube polymer and preparation method thereof

A biocompatible, carbon nanotube technology, applied in the polymer field, can solve the problems of increasing the solubility of carbon nanotubes, restricting research and application, and being difficult to disperse, and achieves the effect of improving biocompatibility and avoiding protein adsorption.

Active Publication Date: 2016-08-24
SUZHOU AIBOMAIER NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The original carbon nanotubes have strong hydrophobicity, and there is a strong agglomeration between each other, which is difficult to disperse in water and organic solvents, which limits their research and application at the molecular level.
In addition, its hydrophobic and agglomerative properties are not conducive to its application in biomedical fields
At present, the most commonly used method for hydrophilic modification of carbon nanotubes is the covalent modification method. The commonly used covalent modification method is to use strong acid to cut into short tubes, and at the same time introduce carboxy groups on the surface, thereby increasing the carbon nanotubes in aqueous solution. However, the concentration of carbon nanotube aqueous solution obtained by strong acid treatment so far is still relatively low, generally 0.01-0.2mg / mL, and has poor affinity with biological macromolecules

Method used

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  • Biocompatible carbon nanotube polymer and preparation method thereof
  • Biocompatible carbon nanotube polymer and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A method for preparing a biocompatible carbon nanotube polymer, comprising the following steps: (1) mixing 0.9 g of carbon nanotubes and 4 g of potassium hydroxide, and milling in a ball mill at a speed of 100 rpm for 2 hours; (2) adding 100 mL Dissolve in deionized water, raise the temperature to 60°C and use a cell pulverizer to sonicate for 30 minutes; (3) filter, wash with water, and dry in an oven to obtain surface hydroxylated carbon nanotubes; (4) 1g of 2-dodecane Trithiocarbonate-2-methylpropionic acid, 0.9g dicyclohexylcarbodiimide, 0.53g 4-dimethylaminopyridine and 11mL dichloromethane were mixed, stirred and dissolved under nitrogen protection; (5) Surface hydroxylated carbon nanotubes were mixed with 7 mL of dichloromethane and dispersed ultrasonically for 3 minutes; (6) Mix the above two mixtures and stir at 25°C for 12 hours; (7) Filter and wash with dilute hydrochloric acid and dichloromethane The product was washed with methane and dried in vacuum to obt...

Embodiment 2

[0033] A method for preparing a biocompatible carbon nanotube polymer, comprising the following steps: (1) mixing 1 g of carbon nanotubes and 5 g of potassium hydroxide, and milling in a ball mill at a speed of 105 rpm for 2.25 hours; (2) adding 110 mL to Dissolve in ionized water, heat up to 65°C and use a cell pulverizer to sonicate for 35 minutes; (3) After filtering, wash with water, and dry in an oven to obtain surface hydroxylated carbon nanotubes; (4) Mix 1.05g of 2-dodecane Trithiocarbonate-2-methylpropionic acid, 0.92g dicyclohexylcarbodiimide, 0.54g 4-dimethylaminopyridine and 12mL dichloromethane were mixed, stirred and dissolved under nitrogen protection; (5) Surface hydroxylated carbon nanotubes were mixed with 8 mL of dichloromethane and dispersed ultrasonically for 4 minutes; (6) Mix the above two mixtures and stir at 27°C for 12.5 hours; (7) Filter and wash with dilute hydrochloric acid and dichloromethane The product was washed with methane and dried in vacuum...

Embodiment 3

[0035]A method for preparing a biocompatible carbon nanotube polymer, comprising the following steps: (1) mixing 1.1 g of carbon nanotubes and 5 g of potassium hydroxide, and milling in a ball mill at a speed of 115 rpm for 2.25 hours; (2) adding 120 mL Dissolve in deionized water, raise the temperature to 65°C, and use a cell pulverizer to sonicate for 35 minutes; (3) After filtering, wash with water, and dry in an oven to obtain surface hydroxylated carbon nanotubes; (4) Mix 1.1g of 2-12 Mix alkyltrithiocarbonate-2-methylpropionic acid, 0.94g dicyclohexylcarbodiimide, 0.55g 4-dimethylaminopyridine and 12mL dichloromethane, stir and dissolve under nitrogen protection; (5) Mix surface-hydroxylated carbon nanotubes with 8 mL of dichloromethane and disperse them ultrasonically for 4 minutes; (6) Mix the above two mixtures and stir at 27°C for 12.5 hours; (7) Filter and wash with dilute hydrochloric acid and di The product was washed with methyl chloride and dried in vacuum to ob...

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Abstract

The invention provides biocompatible carbon nanotube polymer and a preparation method thereof. The preparation method comprises the following steps: mixing and ball milling carbon nanotubes and potassium hydroxide, adding water for dissolving and ultrasound treating, and filtering and drying to obtain surface-hydroxylated carbon nanotubes; stirring and dissolving 2-dodecylsulfanylthiocarbonylsulfanyl-2-methylpropionic acid, dicyclohexylcarbodiimide, 4-dimethylaminopyridine and dichloromethane; subjecting the surface-hydroxylated carbon nanotubes and dichloromethane to ultrasound treatment; mixing above mixed liquid, and filtering and drying to obtain solid A; stirring and reacting 2-methacryloyloxyethyl phosphorylcholine, butyl methacrylate, azoisobutyronitrile and absolute ethyl alcohol to obtain reaction liquid B; subjecting the solid A and absolute ethyl alcohol to ultrasound treatment, adding reaction liquid B and stirring, adding trichloromethane and ethyl ether and precipitating and filtering, and drying to obtain a final product. Biocompatibility of material can be effectively improved, reactions such as protein adsorption and blood coagulation are avoided, and the use in the biosensor field and biofuel cell field is facilitated.

Description

technical field [0001] The invention relates to the field of macromolecules, in particular to a biocompatible carbon nanotube polymer and a preparation method thereof. Background technique [0002] Carbon nanotubes are a kind of tubular carbon materials with a single-layer graphite structure whose diameter generally ranges from a few nanometers to tens of nanometers. It has excellent electrical conductivity, electromagnetic properties and mechanical properties, and has broad application prospects in many fields. The original carbon nanotubes have strong hydrophobicity, and there is a strong agglomeration effect between them. They are difficult to disperse in water and organic solvents, which limits their research and application at the molecular level. In addition, its hydrophobic and agglomerative properties are not conducive to its application in biomedical fields. At present, the most commonly used method for hydrophilic modification of carbon nanotubes is the covalent m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F230/02C08F220/18
CPCC08F292/00C08F230/02
Inventor 李子寅林晓杰邬苏东
Owner SUZHOU AIBOMAIER NEW MATERIAL CO LTD