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Propafenone hydrochloride tablets and preparation method thereof

A technology of propafenone hydrochloride tablets and propafenone hydrochloride, which is applied in the field of medicine, can solve problems such as toxic side effects, application restrictions, and inconvenience for patients to adhere to treatment, and achieve the effects of reducing side effects, wide range of drug sources, and low cost

Inactive Publication Date: 2016-08-31
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The application of western medicine treatment is limited due to the existence of adverse reactions and drug tolerance, and although western medicine treatment is effective at that time, it is easy to relapse and cannot be cured after drug withdrawal, and patients with arrhythmia generally need to take medicine for a long time, which is easy to produce a series of toxic effects. Side effects, in traditional Chinese medicine treatment, the curative effect of acupuncture and moxibustion is widely used, but the curative effect of acupuncture and moxibustion is difficult to last, and it is inconvenient for patients to adhere to the treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Propafenone hydrochloride tablets, which are prepared from the following raw materials:

[0033] Propafenone hydrochloride 20kg, traditional Chinese medicine ingredients 30kg, starch 10kg, dextrin 3kg, sucrose 4.5kg, microcrystalline cellulose 2.5kg, 3% hypromellose pulp 20kg, sodium carboxymethyl starch 3.5kg, magnesium stearate 0.4kg, get above-mentioned raw material, granulate according to conventional method, prepare 1,000,000 tablets.

[0034] The Chinese medicine composition is prepared from raw materials of the following weight:

[0035] 35 parts of Danshen, 35 parts of Uncaria, 35 parts of Shicai Ming, 35 parts of Ophiopogon japonicus, 35 parts of Guizhi,

[0036] 33 parts of red peony, 33 parts of curcuma, 33 parts of Puhuang, 33 parts of Anemarrhena, 33 parts of rehmannia,

[0037] 30 parts of burberry, 30 parts of Ligustrum lucidum, 30 parts of epimedium, 30 parts of ginger, 30 parts of licorice,

[0038] 28 parts of Polygonum multiflorum, 28 parts of Atra...

Embodiment 2

[0051] safety test

[0052] Experimental animals and environment: clean grade SD rats, Kunming mice. During the experiment, the experimental environment temperature was 21°C-25°C, and the humidity was 40%-58%.

[0053] Acute toxicity test in mice: 20 healthy Kunming mice with a body weight of 18g-22g were selected, half male and half male. After fasting for 12 hours, the tablet prepared in Example 1 was taken for oral gavage, and administered twice a day, with two oral gavages at intervals of 3 hours. After gavage, observe continuously for two weeks, and record the manifestations of poisoning and death.

[0054] 30-day feeding test: the newly weaned SD rats were randomly divided into two groups, namely the control group and the test group, 20 rats in each group, half male and half male. The control group was given an equal volume of distilled water. The test animals were given intragastric administration, once a day, with a volume of 0.2ml / 100g.bw, for 30 consecutive days....

Embodiment 3

[0059] clinical information

[0060] case selection

[0061] A total of 98 cases of arrhythmia were included in this study, including 50 males and 48 females, aged 33 to 76 years, 12 cases of atrial premature beats, 14 cases of ventricular premature beats, 8 cases of paroxysmal supraventricular tachycardia, atrial There were 35 cases of fibrillation, 22 cases of phlegm and stasis blocking the heart, and 7 cases of heart-blood deficiency. The selected cases were randomly divided into a treatment group and a control group, with 49 cases in the treatment group and 49 cases in the control group. There was no statistically significant difference in gender, age, cardiac function, and disease condition between the two groups (P>0.05), and they were comparable.

[0062] treatment method

[0063] All patients were given routine treatment according to the etiology of the disease and cardiac function.

[0064] The control group was given 150 mg of propafenone hydrochloride tablets, o...

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PUM

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Abstract

The invention relates to propafenone hydrochloride tablets characterized by being prepared from the following raw materials: 50kg of propafenone hydrochloride, 10kg of starch, 3kg of dextrin, 4.5kg of sucrose, 2.5kg of microcrystalline cellulose, 20kg of 3% hydroxypropyl methylcellulose pulp, 3.5kg of carboxymethyl starch sodium and 0.4kg of magnesium stearate, which are granulated according to a conventional method to prepare 1 million tablets. The compound preparation is capable of treating both symptoms and root causes, does not have side effect, is cheap and convenient to prepare, and has wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a propafenone hydrochloride tablet and a preparation method thereof. Background technique [0002] Arrhythmia (Cardiac Arrhythmia) refers to the abnormality of the frequency, rhythm, origin, conduction velocity and excitation sequence of cardiac impulses. Normal cardiac agitation originates in the heart's sinoatrial node, which is the highest "headquarters" for cardiac pacing. The "instructions" issued by the "headquarters" are transmitted to the atrium and ventricle in a certain order and time, and stimulate the corresponding parts of the heart to generate excitement. [0003] Arrhythmia is a common clinical disease and frequently-occurring disease. Severe arrhythmia is one of the final causes of death in patients with myocardial hypertrophy, myocardial ischemia, myocardial infarction and heart failure. In recent years, the non-drug treatment of arrhythmia in Wes...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/20A61P9/06A61K31/138A61K35/618
CPCA61K9/2059A61K31/138A61K35/618A61K36/185A61K36/236A61K36/282A61K36/284A61K36/296A61K36/324A61K36/36A61K36/39A61K36/428A61K36/483A61K36/484A61K36/488A61K36/53A61K36/537A61K36/54A61K36/638A61K36/65A61K36/704A61K36/71A61K36/736A61K36/74A61K36/752A61K36/758A61K36/804A61K36/835A61K36/88A61K36/8905A61K36/8964A61K36/8968A61K36/9066A61K36/9068A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 林祥宇胡百忠薛颖
Owner 仁和堂药业有限公司