Compound sulfanilamide soluble powder and preparation method thereof

A compound sulfonamide and soluble technology, which is applied in powder delivery, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of low solubility and instability, achieve good stability, low price, and improve solubility and stability.

Inactive Publication Date: 2016-08-31
HUNAN TAIGU BIOLOGICAL VETERINARY DRUG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In order to realize the purpose of the present invention, the present invention provides a kind of compound sulfonamide soluble powder and preparation method thereof, fundamentally solve the shortcoming that sulfonamide salt and antibacterial synergist are used in combination in water, the solubility is small, unstable

Method used

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  • Compound sulfanilamide soluble powder and preparation method thereof
  • Compound sulfanilamide soluble powder and preparation method thereof
  • Compound sulfanilamide soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The present embodiment provides a compound sulfonamide soluble powder, which contains 5kg sulfamethoxine sodium per 100kg, 1kg TMP sodium salt (calculated as TMP), 0.2kg edetate disodium, and oral administration of glucose to 100kg.

Embodiment 2

[0026] The present embodiment provides a kind of compound sulfonamide soluble powder, containing 10kg sulfamethoxine sodium in every 100kg, 2.5kg TMP sodium salt (calculated as TMP), 15kg polyethylene glycol 6000 (PEG6000), disodium edetate 0.5 kg, add anhydrous glucose to 100kg.

Embodiment 3

[0028] The present embodiment provides a kind of compound sulfonamide soluble powder, containing 10kg sulfamethazine sodium in every 100kg, 10kg sulfamethoxine sodium, 4kg TMP sodium salt (in TMP), 20kg polyethylene glycol 6000 (PEG6000), Edetate disodium 0.5kg, fructose added to 100kg.

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Abstract

The invention relates to the field of veterinary preparations, and particularly provides compound sulfanilamide soluble powder and a preparation method thereof. The compound sulfanilamide soluble powder is prepared from the following components in parts by weight: 2.5-65.0 parts of a sulfanilamide salt, 0.625-16.250 parts of an antisepsis synergist and 0-50 parts of a stabilizer. By the compound sulfanilamide soluble powder, the problem that the sulfanilamide salt and the antisepsis synergist are easily separated and participated and not dissolved completely in water is solved. An experiment result proves that the stability of active ingredients is good after the compound sulfanilamide soluble powder is dissolved into drinking water. Therefore, the solubility and the stability of the preparation in water are improved; clinical application is also facilitated; and the compound sulfanilamide soluble powder can be applicable to large-scale production.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound sulfonamide soluble powder and a preparation method thereof. Background technique [0002] It has been more than 70 years since Gerhard Dormark discovered the first sulfa drug, Prontosil, in 1935. As of 2005, about 8,500 such drugs have been synthesized successively. And clinically commonly used but more than 20 kinds. Although various antibiotics emerged and developed continuously after the 1940s, and gradually replaced the status of sulfa drugs in clinical practice, they still have unique advantages: wide antibacterial spectrum, stable properties, convenient use, low price, and no consumption. Food can be mass-produced domestically. At the same time, it also has the disadvantages of weak antibacterial activity, many adverse reactions, bacteria are prone to drug resistance, large doses, and a long course of treatment. With the discovery of antimicrobial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/635A61K9/14A61K47/26A61K47/34A61P31/04A61K31/505
CPCA61K45/06A61K9/0095A61K9/145A61K9/146A61K31/505A61K31/635A61K2300/00
Inventor 谭武贵李健林谭石勇吕华林
Owner HUNAN TAIGU BIOLOGICAL VETERINARY DRUG CO LTD
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