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Manufacturing method of bama miniature pig hyperlipidemia model established by feeding high-calorie feed

A high-calorie, feed technology, applied in the field of experimental zoology and basic medicine, can solve the problems of poor repeatability and stability of animal models, long modeling time, etc., and achieve good repeatability and stability.

Inactive Publication Date: 2016-09-07
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in previous studies, due to the different ingredients and proportions of the feed formula, the animal model had poor repeatability and stability, and the modeling time was long.

Method used

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  • Manufacturing method of bama miniature pig hyperlipidemia model established by feeding high-calorie feed
  • Manufacturing method of bama miniature pig hyperlipidemia model established by feeding high-calorie feed
  • Manufacturing method of bama miniature pig hyperlipidemia model established by feeding high-calorie feed

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Experimental materials: 55 healthy Guangxi Bama miniature pigs, aged 6-8 months, weighing (29.88±2.27) kg, male, with normal intestinal flora, provided by Taizhou Taihe Biotechnology Co., Ltd. They were randomly divided into 5 rats in the normal group (fed with basal feed) and 50 rats in the model group (fed with high-fat feed).

[0035] 2. Experimental method.

[0036] Feeding with high-calorie feed: high-calorie feed (the weight percentage of each ingredient in the formula is: butter 10%, peanut oil 6%, bile salt 0.5%, cholesterol 3%, acesulfame potassium 2.5%, basic feed 78%) feeding Bama miniature pigs in the model group, a total of 48 weeks. The body weight of the Bama miniature pigs was measured every day, and the daily food intake of the normal group and the model group were both 3% of the measured body weight, and they drank water freely.

[0037]The raw materials of the basic feed are 80.20% corn, 18.00% bean cake, 0.30% fish meal, 0.40% hydrogen calcium, ...

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Abstract

The invention belongs to the field of experimental zoology and basic medicine, and particularly relates to a manufacturing method of a bama miniature pig hyperlipidemia model established by feeding high-calorie feed. The specific high-calorie feed formula consists of the following components in weight percentages: 10% of beef tallow, 6% of peanut oil, 0.5% of bile salt, 3% of cholesterol, 2.5% of acesulfame potassium and 78% of basic feed. The manufacturing method of the bama miniature pig hyperlipidemia model established by feeding the high-calorie feed comprises the following steps: (1) healthy male Guangxi bama miniature pigs at an age of 6-8 months and a weight of (29.88 + / - 2.27) kg and with normal intestinal flora are selected; (2) the high-calorie feed is used for feeding for 48 weeks, the weights of the bama miniature pigs are measured daily, the daily food intake is 3% of the measured weight, and the pigs have free access to water; and (3) sign indexes of the bama miniature pigs are tested. The animal model established by feeding the high calorie feed has good reproducibility and stability and can be applied to the basic research of the hyperlipidemia.

Description

technical field [0001] The invention belongs to the fields of experimental zoology and basic medicine, and in particular relates to a high-calorie feed and a preparation method for establishing a Bama miniature pig hyperlipidemia model by feeding it. Background technique [0002] Hyperlipidemia, also known as dyslipidemia, refers to the total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL-C), and very low-density lipoprotein (LDL-C) in plasma due to abnormal lipid transport or metabolism. A type of metabolic disease in which the level of one or more of atherosclerotic lipids such as lipoprotein (VLDL-C) is higher than normal, and the level of high-density lipoprotein (HDL-C) is lower than normal. Hyperlipidemia is an important cause of atherosclerosis and the main pathological basis of cardiovascular and cerebrovascular diseases. Its prevention and treatment has attracted widespread attention around the world and has become a current research hotspot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/30A23K20/158A23K10/30A23K10/22A23K20/142A23K20/174A23K20/163A23K20/20A01K67/02
CPCA01K67/02
Inventor 杨关林张哲尹妮姜均文张会永陈岩杨茗茜潘嘉祥高晓宇
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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