Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Plasma miRNA marker relevant to lung adenocarcinoma auxiliary diagnosis and application thereof

An auxiliary diagnosis and lung adenocarcinoma technology, applied in the fields of genetic engineering and oncology, can solve the problems of high price and inability to promote, the detection sensitivity and specificity need to be strengthened, and relying on the experience of the tester. Easy to obtain and stable effect

Active Publication Date: 2016-09-21
朱伟
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, research on the molecular and clinical characteristics of lung cancer continues to deepen, and clinical screening and treatment methods have also made great progress. However, these methods are either too dependent on the experience of the tester, or the price is too high to be popularized, or the detection sensitivity and specificity need to be strengthened

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Plasma miRNA marker relevant to lung adenocarcinoma auxiliary diagnosis and application thereof
  • Plasma miRNA marker relevant to lung adenocarcinoma auxiliary diagnosis and application thereof
  • Plasma miRNA marker relevant to lung adenocarcinoma auxiliary diagnosis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0040] From 2012 to 2014, the inventor collected a large number of venous plasma samples from patients with lung adenocarcinoma and normal physical examination population from the First Affiliated Hospital of Nanjing Medical University, and selected 141 cases of lung adenocarcinoma and 124 cases of The normal control sample was used as the experimental sample for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 19 pairs of lung adenocarcinoma and adjacent tissues, as well as 5 arterial plasma samples were collected. The selected patients' plasma samples were all from newly diagnosed patients who had not undergone surgery, radiotherapy and chemotherapy intervention and were confirmed as lung adenocarcinoma by pathology. The demographic data and clinical data of these samples were collected systematically.

[0041] Refer to the flowchart ( figure 1 ), randomly selected 30 lung adenocarcinoma samples and 10 n...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a plasma miRNA marker relevant to lung adenocarcinoma auxiliary diagnosis and the application thereof. The marker is one or more of miR-19b-3p, miR-21-5p, miR-221-3p, miR-409-3p, miR-425-5p and miR-584-5p. Plasma miRNA serving as the novel biological marker has the advantages of being high in stability, minimally invasive, easy to obtain and high in sensitivity and specificity. Development and utilization of the molecular marker can provide a new direction for diagnosis and further treatment of diseases including tumor. Through the research, a lung adenocarcinoma plasma miRNA marker with clinical diagnosis potential can be obtained in a more targeted mode. Research proves the reliability and repeatability of the group of miRNA as a noninvasive marker for diagnosis of lung adenocarcinoma.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a plasma miRNA marker related to the auxiliary diagnosis of lung adenocarcinoma and its application. Background technique [0002] Lung cancer is a malignant tumor with the highest mortality rate in the world, and non-small cell lung cancer (NSCLC) accounts for 80% of the total number of lung cancers. Non-small cell lung cancer can be divided into lung adenocarcinoma and lung squamous cell carcinoma according to pathological classification, and the incidence of lung adenocarcinoma has surpassed that of lung squamous cell carcinoma and has become the most common type of lung cancer. Surgical treatment is still the most effective method for the treatment of non-small cell lung cancer. However, the vast majority of patients are already in the middle and advanced stages when they see a doctor, so that the median survival period is always hovering at 7-11 months, and th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/68C12N15/113C12N15/11
Inventor 朱伟周鑫束永前刘平闻伟陈彦齐炼文单霞
Owner 朱伟
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com