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Freeze-drying protective agent used for viral vaccine host and preparation method thereof

A dry protective agent and virus vaccine technology, applied in the field of vaccines, can solve problems such as inability to guarantee host activity, and achieve the effects of easy and accurate compatibility and combination, improved stability, and high safety

Inactive Publication Date: 2016-10-12
吴忆春 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a freeze-dried protectant for virus vaccine hosts and a preparation method thereof for the defect that the current protectant only targets the vaccine itself and cannot guarantee the activity of the host. For the design of the host, through research and exploration of substances that have a protective effect on cells, a reasonable synergistic combination is carried out, and the storage conditions of the host cells are optimized through the freeze-drying protective agent, laying a foundation for better preservation of the virus

Method used

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  • Freeze-drying protective agent used for viral vaccine host and preparation method thereof
  • Freeze-drying protective agent used for viral vaccine host and preparation method thereof
  • Freeze-drying protective agent used for viral vaccine host and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0017] The freeze-dried protective agent for virus vaccine hosts consists of the following raw materials in parts by weight: 2 parts of chitosan, 1 part of β-cyclodextrin, 1 part of sodium alginate, 1 part of raffinose, 1 part of Lactic Acid, 2 parts Inositol Phosphatidylate, and 1 part Butylated Hydroxyanisole.

Embodiment 2

[0019] The freeze-dried protective agent for virus vaccine hosts consists of the following raw materials in parts by weight: 3 parts of chitosan, 1.5 parts of β-cyclodextrin, 1.5 parts of sodium alginate, 2 parts of raffinose, 1.5 parts of Lactic acid, 2 parts inositol phosphatidylate, and 2 parts butylated hydroxyanisole.

Embodiment 3

[0021] The freeze-dried protective agent for virus vaccine hosts consists of the following raw materials in parts by weight: 5 parts of chitosan, 3 parts of β-cyclodextrin, 2 parts of sodium alginate, 4 parts of raffinose, 2 parts of Lactic Acid, 4 parts Inositol Phosphatidylate, and 3 parts Butylated Hydroxyanisole.

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Abstract

The invention belongs to the technical field of vaccines and particularly relates to a freeze-drying protective agent used for a viral vaccine host and a preparation method thereof. The freeze-drying protective agent used for the viral vaccine host includes chitosan, beta-cyclodextrine, sodium alginate, raffinose, lactic acid, inositol phosphoglyceride and butyl hydroxy anisd. The freeze-drying protective agent used for the viral vaccine host is designed for the host, and reasonable synergistic combination is conducted by researching and exploring matter having a protective function on cells. Host cell preservation conditions are optimized by means of the freeze-drying protective agent, and a foundation is laid for better virus preservation.

Description

technical field [0001] The invention belongs to the technical field of vaccines, and in particular relates to a freeze-drying protective agent for virus vaccine hosts and a preparation method thereof. Background technique [0002] The protective agent is a combined reagent used to ensure the smooth adjustment of osmotic pressure during the freeze-drying process and reduce the damage to the freeze-dried object. Freeze-drying technology was invented by the British Wollaston, and then this technology began to be applied to the freeze-drying preservation of bacteria, vaccines and other biological products, and achieved good results. There are many types of common freeze-drying protective agents, mainly sugars, polyols, amino acids, anhydrous solvents and other substances. The existing technology mainly focuses on heat-resistant freeze-drying protective agents and preparation processes for biological products; Lyoprotectants and preparation techniques, etc., are all aimed at the...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/40A61K47/26A61K47/12A61K47/24A61K47/10A61P31/12
CPCA61K47/10A61K47/12A61K47/24A61K47/26A61K47/36A61K47/40
Inventor 吴忆春赵春海苗立忠
Owner 吴忆春
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