Preparation method of nano-micelles with mucous layer permeation and P-gp inhibition dual effects

Abstract

The invention discloses a preparation technology of nano-micelles for conveying anti-tumor medicines through oral administration, namely a preparation method of nano-micelles with mucous layer permeation and P-gp inhibition dual effects. Chitosan, quercetin and 6-phosphogluconic acid are used as raw materials to prepare an amphiphilic chitosan-quercetin succinate-6-phosphogluconic acid copolymer through a condensation and esterification method and a target product is synthesized through a self-assembling technology; the nano-micelles have a good mucous layer permeation capability and also has the P-gp inhibition effect; the oral administration conveying efficiency of the anti-tumor medicines can be effectively improved. The nano-micelles can be used for medical biological materials and medicine carriers and have good research and development application prospects.

Description

technical field

[0001] The invention belongs to the field of pharmacy, and belongs to the preparation technology of nano micelles with dual functions of mucus layer penetration and P-gp inhibition. Background technique

[0002] With the continuous deepening of the research and application of nanotechnology in the field of biomedicine, nanocarrier materials have shown unique efficacy in solving the difficulty of transporting hydrophobic drugs in vivo, destroying the activity of drug molecules in the gastrointestinal tract environment, and improving bioavailability. effects that cannot be achieved with other formulations. It is generally believed that the intestinal mucosal barrier is the main factor restricting the intestinal absorption efficiency of nano-preparations. Positively charged nano-preparations adhere to small intestinal epithelial cells through electrostatic interaction, and promote the phagocytosis and transport of nano-preparations by cells, but are easily trap...

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