35results about How to "The preparation technology is simple" patented technology

The invention relates to a preparation method of amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response. Thiolated chitosan, carboxymethyl chitosan, sodium tripolyphosphate, doxorubicin hydrochloride and hydrogen peroxide are taken as raw materials. The preparation method comprises the following steps: mixing a thiolated chitosans solution with a doxorubicin hydrochloride solution so as to obtain a solution I; mixing a carboxymethyl chitosan solution with a sodium tripolyphosphate solution so as to obtain a mixed solution II; dropwise adding the mixed solution I into the mixed solution II while stirring, controlling the dosage of carboxymethyl chitosan and thiolated chitosan, regulating the ph value of the solution to 6-8, performing ultrasonic blending, performing ion crosslinking and polymer condensing, then dropwise adding hydrogen peroxide into the system so as to finish oxidization crosslinking, performing room-temperature stirring reaction, separating products, and drying the products to obtain the amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response. The amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response is capable of escaping away from tumor cell endosome / lysosome, is capable of automatically regulating and controlling to realize cytoplast release based on unique microenvironments of tumor cells, improving the amycin medicine delivery efficiency and the medical effect, and has a favorable research and development application background in multiple aspects such as medicine and medical materials.

The invention relates Sn-based alloy containing Ti and the method of smelting, which is used for Nb3Sn superconductive fold yarn. The method comprises the following characteristics: Sn-based alloy containing 2%-3wt% Ti, the compound made by Ti and Sn is distributed in Sn base in the form of small dispersion globularity or needle particle. The process comprises the following steps: using the Sn and Sn-Ti intermediate alloy as raw materials, melting them and carriying out moulding. Using the method, the size of Sn-Ti compound particle in Sn base is small, and the method improves the Jcn of inner Sn method Nb3Sn fold yarn.

The invention discloses a preparing method of high-dielectric adjustable film material of strontium lead titanate doped magnesium, which comprises the following steps: adopting butyl phthalate, lead acetate, strontium carbonate and magnesium carbonate as raw material; making ethandiol dimethyl ether and acetate as solvent; allocating sol former; adopting allocated relative sol former as coating solution; using immersing sash method to prepare film layer; drying the coating; disposing under high-temperature; sintering to obtain PSMT ferric electric film.

The invention discloses a slow-release pesticide for preventing and treating corn ear pests, wherein the slow-release pesticide is prepared by the following method: dissolving chitosan by using glacial acetic acid and / or sodium acetate aqueous solution, and uniformly stirring to obtain a chitosan solution; adding an emulsifier into the chitosan solution, and uniformly stirring to obtain a first mixed solution; dissolving a pesticide active agent into an organic solvent to obtain a pesticide dissolving solution, then dropwise and rapidly dripping the pesticide dissolving solution into the firstmixed solution under a stirring condition, and uniformly stirring to obtain a second mixed solution; dropwise adding a cross-linking agent into the second mixed solution, and uniformly stirring to obtain a third mixed solution; dropwise adding a carboxymethyl chitosan aqueous solution into the third mixed solution, and uniformly stirring to obtain a pesticide active agent entrapped micron dispersion body; and centrifugally removing the micron dispersion body to obtain the slow-release pesticide. The slow-release pesticide provided by the invention can effectively control the release time of the pesticide and reduce the risk of percutaneous poisoning during pesticide application.

The invention relates to a polyamino acid fertilizer auxiliary and a preparation method for the same. The method comprises the three steps of preparation of a mixed catalyst, preparation of mixed amino acid salt and preparation of the polyamino acid fertilizer auxiliary. The invention also relates to the use of the polyamino acid fertilizer auxiliary for the production of urea, ammonium bicarbonate, monoammonium phosphate, diammonium phosphate, potassium chloride, potassium sulfide, a compound fertilizer or a medium trace element fertilizer or for fertilizer drip-irrigation, spray irrigation and microspray irrigation systems, wherein the weight ratio of the fertilizer auxiliary to the fertilizer is (5-100):1000. According to the polyamino acid fertilizer auxiliary, the preparation method and the use, the activity of root systems of crops can be improved, the yield of the crops can be remarkably increased, the apparent utilization ratio of a nitrogenous fertilizer can be increased, and the volatilization loss of ammonium is reduced; the product has the characteristics of environment friendliness, supplementation of the trace elements to soil and the like.

The invention relates Sn-based alloy containing Ti and the method of smelting, which is used for Nb3Sn superconductive fold yarn. The method comprises the following characteristics: Sn-based alloy containing 2%-3wt% Ti, the compound made by Ti and Sn is distributed in Sn base in the form of small dispersion globularity or needle particle. The process comprises the following steps: using the Sn and Sn-Ti intermediate alloy as raw materials, melting them and carriying out moulding. Using the method, the size of Sn-Ti compound particle in Sn base is small, and the method improves the Jcn of inner Sn method Nb3Sn fold yarn.

The invention discloses an epitaxial barium strontium niobate thin film with a transparent conductive lithium nickel oxide bottom electrode and a preparation method thereof. On one side of the MgO substrate, an LNO thin film, a transparent conductive layer of LNO lithium nickelate, is epitaxially deposited, and then an SBN thin film is epitaxially prepared on the LNO thin film. The preparation steps are as follows: first, using lithium carbonate, nickel oxide, niobium oxide, strontium carbonate, and barium carbonate as raw materials, the lithium nickelate target and the strontium barium niobate target are prepared respectively by solid-state sintering; secondly, the (001) MgO After the substrate is cleaned, put it into the reaction chamber. The reaction chamber is evacuated, and the substrate is heated. Oxygen is used as a protective gas to introduce into the reaction chamber. barium film. The preparation method of the invention is simple, and the obtained barium strontium niobate thin film grows epitaxially in the (001) direction, the thin film has good epitaxy, high quality, large electro-optical coefficient (r33 can reach 180-230pm / V), and has good application prospect.

The invention discloses a preparing method of high-dielectric adjustable film material of strontium lead titanate doped magnesium, which comprises the following steps: adopting butyl phthalate, lead acetate, strontium carbonate and magnesium carbonate as raw material; making ethandiol dimethyl ether and acetate as solvent; allocating sol former; adopting allocated relative sol former as coating solution; using immersing sash method to prepare film layer; drying the coating; disposing under high-temperature; sintering to obtain PSMT ferric electric film.

The invention discloses a preparation method of fibroin blending material with gradually degrading performance, comprising the following steps of: (1) firstly, preparing fibroin protein peptide powder of which the molecular weight is less than 5000Da; (2) dissolving or dispersing the fibroin protein peptide powder into water to be blended with polyvinyl alcohol aqueous solution, and stirring to react for 10-60min, wherein the polymerization degree of polyvinyl alcohol is 1700-2400; (3) adding polyethylene glycol in the blending material aqueous solution, wherein the modular amount of polyethylene glycol is 200-600, and stirring to react for 5-10h to obtain the blending material aqueous solution; and (4) condensing the blending material aqueous solution to 5-10%, and preparing various drugslow-releasing materials of specific forms as required. The fibroin blending material prepared with the preparation method can be used for the slow releasing of drug, has the advantages of good degrading capability and physical performance and is easy to regulate and adsorb by the human body.

The invention relates to a preparation method of amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response. Thiolated chitosan, carboxymethyl chitosan, sodium tripolyphosphate, doxorubicin hydrochloride and hydrogen peroxide are taken as raw materials. The preparation method comprises the following steps: mixing a thiolated chitosans solution with a doxorubicin hydrochloride solution so as to obtain a solution I; mixing a carboxymethyl chitosan solution with a sodium tripolyphosphate solution so as to obtain a mixed solution II; dropwise adding the mixed solution I into the mixed solution II while stirring, controlling the dosage of carboxymethyl chitosan and thiolated chitosan, regulating the ph value of the solution to 6-8, performing ultrasonic blending, performing ion crosslinking and polymer condensing, then dropwise adding hydrogen peroxide into the system so as to finish oxidization crosslinking, performing room-temperature stirring reaction, separating products, and drying the products to obtain the amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response. The amycin controlled-release chitosan nano particles with pH / oxido-reduction dual response is capable of escaping away from tumor cell endosome / lysosome, is capable of automatically regulating and controlling to realize cytoplast release based on unique microenvironments of tumor cells, improving the amycin medicine delivery efficiency and the medical effect, and has a favorable research and development application background in multiple aspects such as medicine and medical materials.

The invention provides a method for preparing hulless oat blood sugar reducing polypeptide with hulless oat albumen powder. The method comprises the steps that degreased hulless oat albumen powder is added into pure water at the material to liquid ratio of 1:(100-500), the pH value is regulated to be 1.0-3.0 with 1M hydrochloric acid, pepsin is added according to E / S of 1:(50-100), enzymolysis is carried out for 1-4 h at 37 DEG C, and primary enzymatic hydrolysate is obtained; the pH value of the primary enzymatic hydrolysate is regulated with 1M NaoH to be 7.0-8.0, then trypsin, alpha-chymotrypsin and elastase are added according to E / S of 1:(50-100), enzymolysis is carried out for 1-4 h at 37 DEG C, and secondary enzymatic hydrolysate is obtained; the secondary enzymatic hydrolysate is heated to 95 DEG C for enzyme denaturalixation for 15 min, spraying drying is carried out, and polypeptide containing alpha glucosidase inhibiting activity is obtained. The process is simple, the production cost is low, and the product is safe and free of toxic or side effects. The hulless oat blood sugar reducing polypeptide prepared through the method can be applied in preparing medicine or health-care products for preventing and treating diabetes.

The invention relates to a method for preparing chitosan grafted cetirizine nano-micelles in the field of biotechnologies. Chitosan and cetirizine hydrochloride are used as raw materials, chitosan and cetirizine grafted materials are synthesized by the aid of carbodiimide processes, and ultrasonic treatment is carried out on chitosan and cetirizine grafted material solution to obtain the chitosan grafted cetirizine nano-micelles. The method includes carrying out desalting treatment on the cetirizine hydrochloride; adding carboxyl activators into the cetirizine hydrochloride, activating carboxyl and then mixing the cetirizine hydrochloride with chitosan solution; carrying out continuous reaction to obtain reaction products; sufficiently dialyzing and drying the reaction products to obtain chitosan grafted cetirizine; carrying out ultrasonic treatment on chitosan grafted cetirizine solution to obtain the chitosan grafted cetirizine nano-micelles. The method has the advantages that the substitution degree of the chitosan grafted cetirizine nano-micelles is 2.8-5.6%, the chitosan grafted cetirizine nano-micelles are regularly spherical, the particle sizes of the chitosan grafted cetirizine nano-micelles are 80.6-320.1 nm, and the method has excellent research and development application prospects in the aspects of chronic rhinitis and asthma treatment and the like.

The invention discloses an epitaxial lead strontium titanate film with a lithium nickelate buffer layer and a preparation method. A layer of buffer layer conductive electrode LNO film is deposited on one side of the MgO substrate, and a perovskite phase PST film is deposited on the buffer layer conductive electrode LNO film. The steps are as follows: firstly, using lithium carbonate, nickel oxide, lead carbonate, strontium carbonate and titanium oxide as raw materials, respectively preparing lithium nickelate target material and strontium lead titanate target material by solid-phase sintering method; secondly, using (001) MgO substrate After cleaning, it was put into the reaction chamber, the reaction chamber was evacuated, and the substrate was heated. Oxygen was used as a protective gas, introduced into the reaction chamber, and the target was sputtered by pulsed laser, and the lithium nickelate buffer layer and strontium lead titanate were epitaxially deposited on the substrate successively. film. The preparation method of the invention is simple, the prepared strontium lead titanate thin film has good epitaxy and high quality, and the dielectric adjustability of the thin film can reach 40% to 70%.

The invention relates to a polyamino acid fertilizer auxiliary and a preparation method for the same. The method comprises the three steps of preparation of a mixed catalyst, preparation of mixed amino acid salt and preparation of the polyamino acid fertilizer auxiliary. The invention also relates to the use of the polyamino acid fertilizer auxiliary for the production of urea, ammonium bicarbonate, monoammonium phosphate, diammonium phosphate, potassium chloride, potassium sulfide, a compound fertilizer or a medium trace element fertilizer or for fertilizer drip-irrigation, spray irrigation and microspray irrigation systems, wherein the weight ratio of the fertilizer auxiliary to the fertilizer is (5-100):1000. According to the polyamino acid fertilizer auxiliary, the preparation method and the use, the activity of root systems of crops can be improved, the yield of the crops can be remarkably increased, the apparent utilization ratio of a nitrogenous fertilizer can be increased, and the volatilization loss of ammonium is reduced; the product has the characteristics of environment friendliness, supplementation of the trace elements to soil and the like.

The invention provides a doxycycline controlled-release quaternary-ammonium-salt chitosan-lipidosome composite nanoparticle with pH responsiveness and a preparation method thereof. The doxycycline controlled-release quaternary-ammonium-salt chitosan-lipidosome composite nanoparticle prepared by adopting chitosan, lecithin, doxycycline, iodomethane and the like as raw materials and adopting a thin-film dispersion method and a positive-negative charge adsorption method can be adsorbed on the surface of a pellicle by charge action, and when the composite nanoparticle is in a unique low-pH environment of the pellicle, free amino groups without being quaternized in the quaternary-ammonium-salt chitosan generate protonation reaction, so that a nanoparticle shell carries more positive charges, the stability of the original quaternary-ammonium-salt chitosan-lipidosome nanoparticle is destructed, the release of doxycycline at the pellicle is promoted and finally the effects of destructing the pellicle and killing germs are achieved. The doxycycline controlled-release quaternary-ammonium-salt chitosan-lipidosome composite nanoparticle with pH responsiveness and the preparation method provided by the invention have the advantages that the medicine delivery efficiency and the medical effect of the doxycycline are improved and the prospect of study, development and application in the aspects of medicines and medical materials and the like is good.

An organic-inorganic perovskite solar cell whose structural composition is ITO electrode substrate / SnO 2 Electron transport layer / active layer of perovskite material / hole transport layer / nanoporous gold film. Specifically, the nanoporous gold film is kept in 69wt% nitric acid for 6 hours, and then the nanoporous gold film is washed three times with deionized water and dried. The simple transfer technology of the invention transfers the porous metal film electrode to the organic-inorganic perovskite solar cell, simplifies the preparation process, reduces energy consumption, and saves preparation cost. The prepared organic-inorganic perovskite solar cell has a short-circuit current density of 21.1mA / cm 2 , obtained a high conversion efficiency of 19.0%, and good stability. Reducing the consumption of precious metal materials and reducing metal environmental pollution will lay the foundation for the commercial application of organic-inorganic perovskite solar cells.

The invention discloses a preparation technology of nano-micelles for conveying anti-tumor medicines through oral administration, namely a preparation method of nano-micelles with mucous layer permeation and P-gp inhibition dual effects. Chitosan, quercetin and 6-phosphogluconic acid are used as raw materials to prepare an amphiphilic chitosan-quercetin succinate-6-phosphogluconic acid copolymer through a condensation and esterification method and a target product is synthesized through a self-assembling technology; the nano-micelles have a good mucous layer permeation capability and also has the P-gp inhibition effect; the oral administration conveying efficiency of the anti-tumor medicines can be effectively improved. The nano-micelles can be used for medical biological materials and medicine carriers and have good research and development application prospects.

The invention provides a high-performance carbon-based negative electrode material suitable for a lithium ion battery and a preparing method thereof. An improved fused salt heating method is used as the preparing method, a three-dimensional structure carbon material having the high specific surface and microtopography at the same time is obtained. The morphology structure is characterized in that a conductive one-dimensional linear carbon material or a conductive two-dimensional sheet-shaped carbon material serves as a framework, and the outer surface of the framework is evenly coated with porous carbon particles. The carbon material serves as the high-performance negative electrode material of the lithium ion battery and has the advantages of being high in mass energy density, good in large-current discharging capacity, long in service life, environmentally friendly and free of heavy metal elements. The preparing method is simple, low in requirement for reaction devices and suitable for industrial production.