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Sodium alginate degradation method

A sodium alginate and acid solution technology, which is applied in the field of polysaccharide degradation, can solve the problems of high degradation cost and difficult separation of degradation products, and achieve the effects of simple preparation technology, convenient product separation, and low manufacturing cost

Inactive Publication Date: 2017-04-19
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a new method for degrading sodium alginate, which can degrade sodium alginate under heterogeneous conditions, and part of the reaction solution can be recycled. This method can solve the problems of high degradation cost and difficult separation of degradation products. question

Method used

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  • Sodium alginate degradation method

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Disperse 1 part (g) of sodium alginate with an initial viscosity-average molecular weight of 50,075,000 Daltons in 40 parts (ml) of a 13 mol / L ethanol solution, and add 20 parts ( ml), reflux reaction at 50°C for 48 hours, filter the reaction system, wash the filter residue with deionized water and 75% ethanol solution until neutral, disperse in 75% ethanol solution, add sodium hydroxide solution dropwise, adjust the pH of the system to greater than or equal to 7, the obtained sodium alginate suspension was suction-filtered, and the filter residue was washed with 75% ethanol until neutral, then washed with graded alcohol (75%, 95%, absolute ethanol) and dehydrated. Dry under vacuum at 60°C. The degraded sodium alginate was measured by Ubbelohde's viscosity method, and the viscosity-average molecular weight was 2,068,400 Daltons.

Embodiment 2

[0019] Disperse 1 part (g) of sodium alginate with an initial viscosity-average molecular weight of 59,095,000 Daltons in 45 parts (ml) of a 24 mol / L methanol solution, and add 15 parts ( ml), reflux at 80°C for 24 hours, filter the reaction system, wash the filter residue with deionized water and 75% ethanol solution to neutrality, disperse in 75% ethanol solution, add sodium hydroxide solution dropwise, adjust the pH of the system to greater than or equal to 7, the obtained sodium alginate suspension was suction-filtered, and the filter residue was washed with 75% ethanol until neutral, then washed with graded alcohol (75%, 95%, absolute ethanol) and dehydrated. Dry under vacuum at 60°C. The degraded sodium alginate was measured by Ubbelohde's viscosity method, and the viscosity-average molecular weight was 10,172,200 Daltons.

Embodiment 3

[0021] Disperse 1 part (g) of sodium alginate with an initial viscosity-average molecular weight of 38,690,500 Daltons in 50 parts (ml) of 5 mol / L n-propanol solution, and add acetic acid solution with a molar concentration of 17 mol / L under stirring for 10 Parts (ml), reflux at 70°C for 0.5 hours, filter the reaction system, wash the filter residue with deionized water and 75% ethanol solution to neutrality, disperse in 75% ethanol solution, add sodium hydroxide solution dropwise, mediate When the pH of the system is greater than or equal to 7, the obtained sodium alginate suspension is suction-filtered, and the filter residue is washed with 75% ethanol until neutral, then washed with gradient alcohol (75%, 95%, absolute ethanol) and dehydrated. Dry under vacuum at 60°C. The degraded sodium alginate was measured by Ubbelohde's viscosity method, and the viscosity-average molecular weight was 11,633,500 Daltons.

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Abstract

The invention belongs to the technical field of polysaccharide degradation, and relates to a sodium alginate degradation method, which is characterized by comprising: 1) dispersing sodium alginate in an alcohol solution, adding an acid solution under a stirring condition, carrying out a reflux reaction under a thermal insulation state, stirring, and controlling the degradation time so as to complete the degradation reaction; 2) filtering the reaction system obtained in the step 1), washing the solid sequentially with deionized water and 75% ethanol to achieve a neutral state, dispersing in 75% ethanol, adding a sodium hydroxide solution under stirring, and adjusting the pH value of the system to more than or equal to 7; and 3) filtering the reaction system obtained in the step 2), washing the solid with 75% ethanol to achieve a neutral state, washing sequentially with 75% ethanol, 95% ethanol and dehydrated alcohol, dewatering, and carrying out vacuum drying to obtain the degraded sodium alginate product. According to the present invention, the method has advantages of convenient operation, simple preparation technology process, low manufacturing cost, and the like; the sodium alginate is dispersed in the blending liquid of the alcohol and the acid to carry out the heterogeneous degradation reaction so as to conveniently separate the product at the late stage; and the obtained degraded sodium alginate is the white or light yellow solid powder, and is dissolved in water to form the viscous liquid.

Description

technical field [0001] The invention relates to a sodium alginate degradation method in the technical field of polysaccharide degradation. Background technique [0002] Sodium alginate, also known as alginate, is a natural polysaccharide, which is a block composed of two monomers, β-D-1,4-mannuronic acid and α-L-1,4-guluronic acid Linear polymer, white or light yellow powder. Sodium alginate has the functions of anti-tumor, regulating immunity, eliminating free radicals and anti-oxidation, anti-hyperlipidemia, lowering blood sugar, resisting radiation and playing a protective effect. It has good biocompatibility and unique gel ability. It has anticoagulant effect and can be used to treat cardiovascular diseases; it has hemostatic effect in vitro and can be used to develop external medical dressings. [0003] The molecular weight of sodium alginate is as high as tens of millions. High molecular weight sodium alginate has a low degradation rate in the body, and there is no e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04
Inventor 陈西广郎需谦程晓杰孔明刘雅冯超
Owner OCEAN UNIV OF CHINA
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