Preparation method of fibroin blending material with gradually degrading performance

Abstract

The invention discloses a preparation method of fibroin blending material with gradually degrading performance, comprising the following steps of: (1) firstly, preparing fibroin protein peptide powder of which the molecular weight is less than 5000Da; (2) dissolving or dispersing the fibroin protein peptide powder into water to be blended with polyvinyl alcohol aqueous solution, and stirring to react for 10-60min, wherein the polymerization degree of polyvinyl alcohol is 1700-2400; (3) adding polyethylene glycol in the blending material aqueous solution, wherein the modular amount of polyethylene glycol is 200-600, and stirring to react for 5-10h to obtain the blending material aqueous solution; and (4) condensing the blending material aqueous solution to 5-10%, and preparing various drugslow-releasing materials of specific forms as required. The fibroin blending material prepared with the preparation method can be used for the slow releasing of drug, has the advantages of good degrading capability and physical performance and is easy to regulate and adsorb by the human body.

Description

technical field [0001] The invention relates to a preparation method of a silk fibroin blended material. The silk fibroin blended material can be used as a drug sustained-release carrier, and belongs to the technical field of biological materials. [0002] Background technique [0003] The drug sustained-release system is beneficial to improve the efficacy of drugs, reduce the toxic and side effects, and relieve the pain of repeated drug use. In the drug sustained-release system, in addition to the drug itself, the drug carrier also plays an important role. Synthetic polymer carriers often have poor biocompatibility, and sometimes contain traces of toxic impurities such as initiators, which are prone to cytotoxicity. However, natural polymers do not have the above shortcomings, and the research on silk fibroin as a drug carrier has attracted much attention. Silk fibroin is a natural polymer material derived from silk, with stable chemical properties, no toxic side effects ...

AI Technical Summary

Problems solved by technology

[0005] At present, silk fibroin blend materials are mainly used in spinning, and there are few researches on drug sustained-release carrier materials in tissue engineering scaffolds.

Moreover, most of the existing studies use silk fibroin with a large molecular weight, which has limited degradability, and some have poor physical properties in aqueous media, and are difficult to control in slow and controlled release. The practical application is difficult, and there are still many problems.

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