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Application of phillyrin, phillyrin derivatives, and phillyrin/phillygenin composition in preparation of drugs for relieving and treating pain

A technology of forsythin derivatives and forsythiacin, which is applied in the field of medicine, can solve the problems of narrow scope of action of non-steroidal anti-inflammatory analgesics, enhanced gastrointestinal discomfort, and impaired awareness of drug resistance, etc. Strong pharmacological effect, significant conditioning and pain treatment, easy to promote

Inactive Publication Date: 2016-11-02
富力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these two types of drugs have a long history, they all have certain defects: NSAIDs have a narrow range of action, are only effective for mild and moderate pain associated with inflammation, With the increase of dose, the discomfort reaction of gastrointestinal tract is enhanced; while opioid analgesics have a wide range of effects, but they have drug resistance and toxic side effects such as nausea, constipation and impaired consciousness. Great harm, so that the application of opioids is strictly controlled

Method used

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  • Application of phillyrin, phillyrin derivatives, and phillyrin/phillygenin composition in preparation of drugs for relieving and treating pain
  • Application of phillyrin, phillyrin derivatives, and phillyrin/phillygenin composition in preparation of drugs for relieving and treating pain
  • Application of phillyrin, phillyrin derivatives, and phillyrin/phillygenin composition in preparation of drugs for relieving and treating pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Forsythin Tablets

[0041] 1. Prepare raw materials according to the following ratio

[0042]

[0043] 2. Mix forsythin and starch evenly, make granules, add talcum powder and magnesium stearate, mix evenly, and press into 10,000 tablets.

Embodiment 2

[0044] Example 2 Forsythin Capsules

[0045] 1. Prepare raw materials according to the following ratio

[0046] Forsythin (purity 60%) 200g

[0047] Starch 1000g

[0048] 2. Mix forsythin and starch evenly and pack into capsules to make 10,000 capsules.

Embodiment 3

[0049] Example 3 Forsythin Capsules

[0050] 1. Prepare raw materials according to the following ratio

[0051] Forsythin (purity 98%) 500g

[0052] Starch 1000g

[0053] 2. Mix forsythin and starch evenly and pack into capsules to make 10,000 capsules.

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Abstract

The invention discloses new application of phillyrin, phillyrin derivatives, and a phillyrin / phillygenin composition in preparation of drugs for relieving and treating pain. Tests prove that the phillyrin, phillyrin derivatives, and phillyrin / phillygenin composition have the characteristics of significant curative effect, quick effect and small toxic and side effect in treatment of pain, are a safe, efficient and stable pain treatment drug with a simple preparation process, and are suitable for industrial production and easy for popularization. The invention provides a new drug source for prevention and treatment of pain.

Description

technical field [0001] The invention relates to the field of medicine, and relates to an analgesic drug or health food, in particular to an application of traditional Chinese medicine forsythia and forsythia leaf extract components in pain relief and / or treatment medicine or health food. Background technique [0002] Pain is a complex sensory experience produced by the body in the brain through the transmission of various exogenous and endogenous noxious stimuli through the nervous system. Pain seriously affects human physical and mental health. According to statistics, more than 1 / 3 of the world's population suffers from persistent or periodic pain. Huge pain can affect the functions of various organ systems in the human body, such as causing sleep disorders, inhibited digestion, increased blood pressure, and increased heart rate, etc., and can also lead to low immunity and greatly increase the possibility of illness; in addition, pain has an impact on the patient's psychol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/54A61K36/71A61K36/238A61K36/232A61K36/899A61K36/9062A61K36/51A61P29/00A23L33/10A23L33/105A61K31/375A61K31/34
CPCA61K31/7048A23V2002/00A61K9/0053A61K9/08A61K9/1623A61K9/1652A61K9/2059A61K9/4866A61K31/34A61K31/375A61K36/232A61K36/238A61K36/51A61K36/54A61K36/71A61K36/899A61K36/9062A61K47/26A61K2300/00A23V2200/30
Inventor 惠敏富力王凯乾鲁明明王硕樊宏宇柳洋刘正贤
Owner 富力
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