Lumbar intervertebral disc degeneration animal model biomechanical builder

Abstract

The invention discloses a lumbar intervertebral disc degeneration animal model biomechanical builder which structurally comprises a fixing frame, an animal binding and fixing device with an upper body fixing mechanism and a lower body fixing mechanism and a movement control device controlling the upper body fixing mechanism to move. The fixing frame comprises a top frame, a base and a pair of vertical frames connecting the top frame with the base, and a pair of upper sliding rods and an upper threaded screw positioned between the upper sliding rods. The animal model biological mechanical builder can simulate biomechanical and kinetic characteristics of a human spine to enable an experimental animal body to be in six-position composite motion of forward bending and backward stretching, leftward and rightward bending and leftward and rightward rotating under action of the movement control device to nondestructively build a lumbar intervertebral disc degeneration animal model so as to well represent intervertebral disc degeneration etiology, occurrence regularity and pathologic changes; to-be-intervened sections can be selected according to experiments, and the model is controllable and standardized.

Description

technical field [0001] The invention relates to the technical field of animal experiments for spinal surgery, in particular to a biomechanical modeling machine capable of constructing animal models of lumbar intervertebral disc degeneration. Background technique [0002] Intervertebral disc degeneration and regeneration have always been the focus and focus of spinal surgery research, and the animal model of intervertebral disc degeneration as an important research carrier plays an indispensable and important role from basic theory to clinical practice, from clinical problems to experimental demonstration. After nearly 80 years of continuous research, there are dozens of methods for constructing animal models of intervertebral disc degeneration, which are mainly divided into four types: biomechanical changes, biological structure destruction, spontaneous degeneration, and systemic diseases. Similar modeling methods. These modeling methods have their own advantages and disadv...

AI Technical Summary

Problems solved by technology

They have their own advantages and disadvantages in terms of simulation, reliability, operability, repeatability, etc., but they have the following three shortcomings: 1. Almost all of them are invasive models, which cause damage to intervertebral discs and related physiological structures to varying degrees , although it can eventually cause pathological degenerative changes, it is significantly different from the etiology and pathogenesis of human intervertebral disc degeneration. Simulation of multi-factor mechanical effects; 3. The pathological process of chronic degeneration of the intervertebral disc cannot be reproduced well

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