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Application of butylphthalide and derivative thereof in preparation of medicine for treating Parkinson's disease

A technology for Parkinson's disease and butylphthalide, which is applied in the field of 3-n-butylphthalide (abbreviated as butylphthalide) and derivatives thereof, and can solve the problem of drugs that do not teach butylphthalide and its derivatives Parkinson's disease, and the like problems, to achieve the effect of exact curative effect, prevent or delay the process, and improve the pathogenesis

Inactive Publication Date: 2016-11-09
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the prior art does not teach that butylphthalide and derivatives thereof can be used for the preparation of medicines for the treatment of Parkinson's disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Butylphthalide.

[0012] Observation in the rotenone PD rat model: PD rats were injected intraperitoneally with butylphthalide, and the effects of butylphthalide on the behavior, midbrain oxidative stress level and substantia nigra DA neurons of PD rats were observed.

[0013] 1. Experimental materials.

[0014] 1. Drug: butylphthalide, provided by CSPC NBP Pharmaceutical Co., Ltd.

[0015] 2. Reagents: Rotenone and apomorphine (APO) are products of Sigma; dimethyl sulfoxide (DMSO),

[0016] Tyrosine hydroxylase (TH) monoclonal antibody and SABC kit are products of Wuhan Boster Company; GSH kit, MDA kit and SOD kit are products of Nanjing Jiancheng Company.

[0017] 3. Instruments: Stereotaxic instrument for rat brain, Shenzhen Ruiwode Company; micro sample injector (5μl), Shanghai Third Analytical Instrument Factory; 721 spectrophotometer, Shanghai Precision Scientific Instrument Co., Ltd.; optical microscope, NikonYS100.

[0018] 4. Experimental anima...

Embodiment 2

[0040] Example 2 L-Butylphthalide.

[0041] Observation in the rotenone PD rat model: intraperitoneally inject L-butylphthalide to PD rats, and observe the effects of L-butylphthalide on the behavior, midbrain oxidative stress level and substantia nigra DA neurons of PD rats.

[0042] 1. The test materials are the same as in Example 1.

[0043] Two, test method is the same as embodiment 1.

[0044] 3. Experimental results.

[0045] (A) Rotation behavior observation.

[0046] 1. There was no significant difference in rotation behavior between the control group and each treatment group before treatment (P>0.05).

[0047] 2. Compared with before treatment, the number of rotations in the control group increased after treatment, and the number of rotations in the 20mg group decreased, but there was no statistical significance (P>0.05). The number of rotations in the 40mg and 80mg groups decreased after treatment compared with before treatment, and there was a significant diff...

Embodiment 3

[0059] Example 3 Propylphthalide.

[0060] Observation in the rotenone PD rat model: intraperitoneal injection of propylphthalide to PD rats to observe the effects of propylphthalide on the behavior, midbrain oxidative stress level and substantia nigra DA neurons of PD rats.

[0061] 1. The test materials are the same as in Example 1.

[0062] Two, test method is the same as embodiment 1.

[0063] 3. Experimental results.

[0064] (A) Rotation behavior observation.

[0065] 1. There was no significant difference in rotation behavior between the control group and each treatment group before treatment (P>0.05).

[0066] 2. Compared with before treatment, the number of rotations in the control group increased after treatment, and the number of rotations in the 20mg and 40mg groups decreased, but there was no statistical significance (P>0.05). In the 80mg group, the number of rotations decreased after treatment compared with before treatment, and there was a significant diff...

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PUM

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Abstract

The invention relates to novel application of 3-n butylphthalide (short for butylphthalid) and a derivative thereof, in particular to application of the compound in preparation of medicine for treating the Parkinson's disease. A hemiparkinsonian rat model is manufactured through stereotactic injection of rotenone for testing, and the result shows that butylphthalide and the derivative thereof can effectively improve symptoms caused by the Parkinson's disease and have the effect of protecting the nerves.

Description

technical field [0001] The present invention relates to the new application of 3-n-butylphthalide (abbreviated as butylphthalide) and its derivatives, and more specifically relates to the application of the compound in the preparation of medicaments for treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a common chronic progressive neurodegenerative disease, and its characteristic pathological change is the degeneration and loss of dopamine (Dopamine, DA) neurons in the substantia nigra compacta. Currently, the etiology of PD is unknown, and theories about the pathogenesis of PD mainly include oxidative stress, mitochondrial dysfunction, calcium overload, toxic effects of excitatory amino acids, and apoptosis. The prevalence in people over 60 years old exceeds 1%, and increases with age. [0003] Alternative therapy represented by levodopa is currently the gold standard for PD. Not only can it not stop the natural process of the disease,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P25/16
CPCA61K31/365
Inventor 牛锋黄憗王涛黄金莎曹菊林郭海波
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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