Unlock instant, AI-driven research and patent intelligence for your innovation.

Pharmaceutical composition of deoxycorticosterone acetate, and application of same to biological medicine

A technology of deoxycorticosterone acetate and its composition, which is applied in the field of biomedicine, can solve the problems that have not been reported related to deoxycorticosterone acetate, and achieve the effect of reducing the content and improving the yellowing effect

Pending Publication Date: 2016-11-09
王昌荣
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between deoxycorticosterone acetate and its pharmaceutical composition and jaundice

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition of deoxycorticosterone acetate, and application of same to biological medicine
  • Pharmaceutical composition of deoxycorticosterone acetate, and application of same to biological medicine
  • Pharmaceutical composition of deoxycorticosterone acetate, and application of same to biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Compound (Ⅰ) isolation preparation and structure confirmation

[0018] Reagent sources: ethanol, petroleum ether, ethyl acetate, n-butanol, dichloromethane are analytically pure, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd., methanol, analytically pure, purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0019] Separation method: (a) Crush Forsythia (2kg), extract with 90% ethanol under hot reflux (20L×3 times), combine the extracts, concentrate until there is no alcohol smell (4L), and use petroleum ether (4L×3 times) in turn ), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) The medium n-butanol extract was removed with AB-8 type macroporous resin. First, eluted with 8% ethanol for 10 column volumes, and then eluted with 70% ethanol for 12 column volumes. Collect 70% eluate and depressurize Concentrate to obtain...

Embodiment 2

[0023] Example 2: Pharmacological effects

[0024] In this example, a one-time intragastric administration of 1-naphthyl isothiocyanate (ANIT) was used to replicate the rat jaundice model, and the drug-induced jaundice model rat serum alanine aminotransferase (ALT) and aspartate amino group were determined. The effect of transferase (AST) and total bilirubin (TBIL) content, observe the protective effect of the drug on the liver.

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] Clean SD rats, both ♀♂, weighing 260~300g, purchased from the Experimental Animal Center of Kunming Medical College.

[0028] 1.2 Reagents and samples

[0029] Deoxycorticosterone acetate was purchased from the National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Bifendate dropping pills (Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, specification 1.5mg / capsule); 1-naphthyl is...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition of deoxycorticosterone acetate, and application of the same to biological medicine. The pharmaceutical composition of deoxycorticosterone acetate contains deoxycorticosterone acetate and a natural product compound (I) with a novel structure. Individual action of deoxycorticosterone acetate or the compound (I) enables the content of TBIL in the serum of a model rat and exerts jaundice removing effect. Combined action of deoxycorticosterone acetate and the compound (I) exerts better jaundice removing effect, so the pharmaceutical composition can be developed into a drug for treating jaundice; and the pharmaceutical composition has outstanding substantive features and substantial progress compared with the prior art.

Description

Technical field [0001] The invention belongs to the field of biomedicine, and relates to a new use of deoxycorticosterone acetate, and specifically relates to a pharmaceutical composition of deoxycorticosterone acetate and its application in biomedicine. Background technique [0002] Deoxycorticosterone acetate is used as an alternative treatment for primary adrenal hypofunction and belongs to the endocrine system. [0003] So far, there has been no report on the correlation between deoxycorticosterone acetate and its pharmaceutical composition and jaundice. Summary of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of deoxycorticosterone acetate, which contains deoxycorticosterone acetate and a natural product with a novel structure, and deoxycorticosterone acetate and the natural product can be used for synergistic treatment jaundice. [0005] The above objectives of the present invention are achieved through the following tech...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D303/40A61K31/573A61K31/336A61P1/16
CPCC07D303/40A61K31/336A61K31/573A61K36/634
Inventor 王昌荣
Owner 王昌荣