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Blood reservoir

A technology for preserving containers and blood, applied to medical containers, suction devices, types of packaging items, etc., to achieve excellent preservation and pressure resistance

Inactive Publication Date: 2016-11-09
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in REACH (Registration, Evaluation, Approval, and Restriction of Chemical Substances) started in Europe in recent years, DEHP is listed as a high-risk substance because of the risk of endocrine disorders (reproductive toxicity) depending on the amount. One, thus, as a material for constituting a blood storage container, it is desired to develop a PVC composition that does not contain DEHP as a plasticizer

Method used

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Experimental program
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Embodiment

[0033] With respect to 100 parts by mass of polyvinyl chloride, a composite plasticizer composed of DiNCH and BTHC was blended in the amount shown in Table 1, and 8 parts by mass of epoxidized soybean oil, 0.048 parts by mass of zinc soap, and 0.064 parts by mass of calcium soap were blended. , to make a resin composition. It should be noted that the combination ratio of DiNCH and BTHC is shown in Table 1.

[0034] [Table 1]

[0035]

[0036] The resin composition was extruded through a T-die to produce a resin sheet having a thickness of 0.4 mm. The prepared two resin sheets were welded to prepare evaluation bags with an inner capacity of 80 mL and an inner capacity of 450 mL. Using the prepared evaluation bag, the erythrocyte storage stability and pressure resistance were evaluated in the following procedure. It should be noted that the preservation of red blood cells was evaluated by the hemolysis rate. The results are shown in Table 1.

[0037] (preservation of red...

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Abstract

A blood reservoir provided with a reservoir main body that is formed of a resin composition comprising, per 100 parts by mass of polyvinyl chloride, 30-70 parts by mass of a composite plasticizer composed of a combination of a first plasticizer with a second plasticizer, characterized by: the first plasticizer being di-isononyl-cyclohexane-1,2-dicarboxylate and the second plasticizer being a citric acid ester; and, in the composite plasticizer, the composition ratio of the first plasticizer to the second plasticizer being 15 / 85 to 93 / 7.

Description

technical field [0001] The present invention relates to a blood storage container for storing blood, especially red blood cell concentrate. Background technique [0002] As a representative material constituting the blood storage container, there is PVC (polyvinyl chloride) containing a plasticizer such as DEHP (diethylhexyl phthalate). PVC is considered to have problems such as the generation of dioxins during disposal, but even so, it is still the mainstream material for blood, especially red blood cell storage containers. The biggest reason is that, for the preservation of erythrocyte concentrate, DEHP contained in PVC oozes into erythrocyte concentrate, thereby inhibiting the morphological change and hemolysis of erythrocytes. However, in REACH (Registration, Evaluation, Approval, and Restriction of Chemical Substances) started in Europe in recent years, DEHP has the risk of endocrine disturbance (reproductive toxicity) depending on the amount, so it is listed as a high...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/10
CPCA61M1/0209A61J1/1468A61M1/0218A61L31/048C08K5/11C08K5/12
Inventor 市川纱如武田典彦高良真一
Owner TERUMO KK
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