Hydrophilic polyurethane, hydrophilic polyurethane foaming body and made wet-type wound dressing

A hydrophilic polyurethane and foam technology, which is applied in the field of polyurethane, can solve the problems of limited wound healing, reduced absorption effect, loss of active ingredients and replacement of dressings, etc., and achieves the effect of promoting wound healing.

Inactive Publication Date: 2016-11-23
TAICEND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to further promote wound healing, active ingredients (for example: alginate, hyaluronic acid or its salts, bismuth subgallate, etc.) that can promote wound healing are usually mixed in the dressing base material or coated on the surface, However, blending or coating not only requires additional processing

Method used

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  • Hydrophilic polyurethane, hydrophilic polyurethane foaming body and made wet-type wound dressing
  • Hydrophilic polyurethane, hydrophilic polyurethane foaming body and made wet-type wound dressing
  • Hydrophilic polyurethane, hydrophilic polyurethane foaming body and made wet-type wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Star-shaped hydrophilic polyurethane PU1

[0027] Mix 1mol PPG6000triol (weight average molecular weight is 6,000) with 3mol HDI, react at 80℃ for 1 hour to obtain star-shaped prepolymer, then add 1mol PEG1000 (weight average molecular weight is 1,000), 1.5mol PEG2000 (weight average molecular weight is 2,000) and 0.5 mol of hyaluronic acid (weight average molecular weight of 1,000,000), crosslinking reaction was performed at 80°C for 6 hours to obtain star-shaped hydrophilic polyurethane PU1.

Example Embodiment

[0028] Star-shaped hydrophilic polyurethane PU2

[0029] Mix 0.5mol PPG6000triol with 2.5mol HDI and react at 80°C for 1 hour to obtain a star-shaped prepolymer. Then add 0.85mol PEG1000, 0.85mol PEG2000 and 0.1mol hyaluronic acid (weight average molecular weight is 1,000,000). Cross-linking reaction was carried out at ℃ for 6 hours to obtain star-shaped hydrophilic polyurethane PU2.

[0030] Wet wound dressing DR1

[0031] Refer to figure 1 , The star-shaped hydrophilic polyurethane PU1 of Example 1 was mixed and stirred with 1mol HDI, then coated on the release film, and heated at 120°C for 1 hour to obtain figure 1 The sheet-shaped absorbent layer 1 is the wet wound dressing DR1.

[0032] Wet wound dressing DR2

[0033] Refer to figure 1 and figure 2 , 0.1mol sodium bicarbonate (blowing agent), 0.4mol water, 0.5mol polydimethylsiloxane-polyoxyalkylene copolymer (surfactant), 0.1mol ethylenediamine and 0.1mol zinc isooctanoate (catalyst , Purchased from Taiwan Xishengjin Chemic...

Example

[0036] Wound dressing CDR2 (sterilized)

[0037] The wound dressing CDR2 of Comparative Application Example 2 is a soft wound dressing 3662A commercially available from 3M Company, and the material in contact with the wound is non-woven fabric.

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PUM

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Abstract

A Hydrophilic polyurethane provided by the invention is made: a first polyether polyol and the polyisocyanates are acted, the second polyether polyol and transparent hyaluronic acid are acted to obtain star-shaped block polyurethane. The first polyether polyol includes at least three polyether polyols. The present invention further provides a hydrophilic polyurethane foaming body made by the hydrophilic polyurethane ad the foaming body, and the holes are non-continuous sealing holes. The present invention further provides wet-type wound dressing comprising a sheet absorbed layer which has the materials of the hydrophilic polyurethane or the hydrophilic polyurethane foaming body. The wet-type wound dressing can make the wound wet and prompt the wound cure and can effectively absorb the wound liquid.

Description

technical field [0001] The invention relates to a polyurethane, in particular to a hydrophilic polyurethane, a hydrophilic polyurethane foam and a prepared wet wound dressing. Background technique [0002] Due to the improvement of health awareness, more attention has been paid to wound care after surgery. Therefore, various wound dressings that can prevent infection and protect wounds have been developed one after another. [0003] In order to further promote wound healing, active ingredients (for example: alginate, hyaluronic acid or its salts, bismuth subgallate, etc.) that can promote wound healing are usually mixed in the dressing base material or coated on the surface, However, blending or coating not only requires additional processing technology, but also these additional active ingredients are easily lost and lost, requiring frequent dressing changes (within about 5 to 7 days), and may also decrease due to active ingredients being absorbed by the dressing substrate....

Claims

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Application Information

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IPC IPC(8): A61F13/02A61M35/00C08G18/48C08G18/64
CPCA61F13/00008A61F13/00017A61F13/00042A61F13/00063A61F13/0223A61M35/00C08G18/4081C08G18/48C08G18/6484
Inventor 萧胜贤
Owner TAICEND TECH
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