Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Leukocyte and thrombocyte filtering membrane and preparation method thereof

A technology for platelets and filtration membranes, applied in the field of leukocyte and platelet filtration membranes and their preparation, can solve the problem of difficulty in ensuring the filtration speed to efficiently filter out leukocytes and platelets, etc., and achieves low hardness, high specific surface area and good flexibility. Effect

Inactive Publication Date: 2016-11-23
广州新克力生物科技有限公司
View PDF8 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the technical problem that it is difficult to efficiently filter white blood cells and platelets while ensuring the filtration speed in the prior art, the purpose of the present invention is to provide a filter membrane for white blood cells and platelets and a preparation method thereof to solve the above defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Leukocyte and thrombocyte filtering membrane and preparation method thereof
  • Leukocyte and thrombocyte filtering membrane and preparation method thereof
  • Leukocyte and thrombocyte filtering membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, a kind of filter membrane of white blood cell and blood platelet

[0037] The filter membrane described in Example 1 of the present invention includes a composite substrate and a polymer coated on the composite substrate, and the composite substrate is prepared from polyurethane and nanocrystalline cellulose at a weight ratio of 1:0.5 , the polymer is composed of polyethylene glycol and nano-hydroxyapatite in a weight ratio of 10:1, the content of the polymer in the filter membrane is 3%, and the polymer in the composite substrate The surface coverage of the polyurethane is 90%, and the weight ratio of the hard segment to the soft segment in the polyurethane is 3:7.

[0038] Preparation:

[0039] A) Take the nano-hydroxyapatite and the polyethylene glycol to dry, dissolve the nano-hydroxyapatite and the polyethylene glycol in acetone at a weight ratio of 10:1, mechanically stir for 8 minutes, ultrasonically disperse for 3 minutes, and statically Place fo...

Embodiment 2

[0042] Embodiment 2, a kind of filter membrane of white blood cell and blood platelet

[0043] The filter membrane described in Example 2 of the present invention includes a composite substrate and a polymer coated on the composite substrate, and the composite substrate is prepared from polyurethane and nanocrystalline cellulose at a weight ratio of 1:0.8 , the polymer is composed of polyethylene glycol and nano-hydroxyapatite in a weight ratio of 10:2, the content of the polymer in the filter membrane is 5%, and the polymer in the composite substrate The surface coverage is 95%, and the weight ratio of the hard segment to the soft segment in the polyurethane is 3:7.

[0044] The preparation method refers to Example 1.

Embodiment 3

[0045] Embodiment 3, a kind of filter membrane of white blood cell and blood platelet

[0046] The filter membrane described in Example 3 of the present invention includes a composite substrate and a polymer coated on the composite substrate, and the composite substrate is prepared from polyurethane and nanocrystalline cellulose in a weight ratio of 1:1 , the polymer is composed of polyethylene glycol and nano-hydroxyapatite in a weight ratio of 10:2, the content of the polymer in the filter membrane is 6%, and the polymer in the composite substrate The surface coverage is 100%, and the weight ratio of the hard segment to the soft segment in the polyurethane is 3:7.

[0047] The preparation method refers to Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Average pore sizeaaaaaaaaaa
Contact angleaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of leukocyte filters, and particularly relates to a leukocyte and thrombocyte filtering membrane and a preparation method thereof. The filtering membrane comprises a composite substrate and a polymer applied to the composite substrate, wherein the composite substrate is prepared from polyurethane and nano-microcrystalline cellulose according to the weight ratio of 1:(0.3-2), and the polymer is prepared from polyethylene glycol and nano-hydroxyapatite according to the weight ratio of 10:(1-2). According to the filtering membrane, leukocytes and thrombocytes can be efficiently filtered while the blood filtering speed is not decreased, the highest filtering rate of the leukocytes and the highest filtering rate of the thrombocytes can reach 99.999% and 92.4% respectively, and only 15-20 min is needed for filtering 400 ml of whole blood; meanwhile, the filtering membrane has the good flexibility, meets the requirement that moderate deformation is needed when the filtering membrane is packaged and can effectively solve the problem that the polymer is prone to be washed out in the subsequent washing process.

Description

technical field [0001] The invention belongs to the field of leukocyte filters, and in particular relates to a filter membrane for leukocytes and platelets and a preparation method thereof. Background technique [0002] At present, the method of removing leukocytes from blood preparations is roughly divided into the following two types: one is the centrifugation method using the difference in specific gravity of blood components; the other is the filtration method using fiber raw materials and porous materials with continuous pores as filter materials, The latter is widely used because of its high ability to filter white blood cells, easy operation, and low cost. However, in recent years, as awareness of the importance of leukocyte-removing blood transfusion has increased, in order to prevent the above-mentioned side effects from occurring, a filter with a higher leukocyte-removing ability is required. [0003] Chinese patent application 201210115812.1 discloses a combined ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01D71/60B01D69/02B01D67/00A61M1/34
CPCB01D71/60A61M1/3413B01D67/0002B01D69/02B01D2323/04B01D2323/12B01D2325/24B01D2325/38
Inventor 王新平
Owner 广州新克力生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com