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Gelatin-calcium alginate core-shell structure sustained release microsphere loaded with bone morphogenetic protein (BMP) and preparation method of gelatin-calcium alginate core-shell structure sustained release microsphere loaded with BMP

A technology of slow-release microspheres and core-shell structure, applied in medical science, prosthesis, etc., can solve the problems of high price and loss of function, and achieve the effects of good biodegradability, good histocompatibility, and rich sources.

Inactive Publication Date: 2016-12-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Bone morphogenetic protein is degraded by the body's enzymes in the body, and it will lose its effect soon, and its price is also very expensive, which is undoubtedly a huge pressure for patients

Method used

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  • Gelatin-calcium alginate core-shell structure sustained release microsphere loaded with bone morphogenetic protein (BMP) and preparation method of gelatin-calcium alginate core-shell structure sustained release microsphere loaded with BMP
  • Gelatin-calcium alginate core-shell structure sustained release microsphere loaded with bone morphogenetic protein (BMP) and preparation method of gelatin-calcium alginate core-shell structure sustained release microsphere loaded with BMP
  • Gelatin-calcium alginate core-shell structure sustained release microsphere loaded with bone morphogenetic protein (BMP) and preparation method of gelatin-calcium alginate core-shell structure sustained release microsphere loaded with BMP

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Effect test

Embodiment 1

[0038] a kind of like figure 2 , image 3 The gelatin / calcium alginate core-shell structure slow-release microspheres loaded with BMP are shown. The core-shell structure slow-release microspheres include an inner core layer and an outer coating layer from the inside to the outside. The inner core layer is mainly composed of uniformly dispersed bone It is composed of gelatin microspheres that produce protein, and the outer coating layer covered by the inner core layer is mainly composed of calcium alginate. The core-shell structure slow-release microsphere is a spherical body with a smooth surface, and the core-shell structure slow-release microsphere has a diameter of 72.61-151.37 μm and an average particle diameter of 109 μm. The drug loading amount of bone morphogenetic protein per milligram of the core-shell sustained-release microspheres of this embodiment is 32.99 micrograms.

[0039] The preparation method of the BMP-loaded gelatin-calcium alginate core-shell structur...

Embodiment 2

[0053] A gelatin-calcium alginate core-shell structure slow-release microsphere loaded with BMP, the core-shell structure slow-release microsphere sequentially includes an inner core layer, a middle layer and an outer coating layer from the inside to the outside, and the inner core layer is mainly composed of uniform It is composed of gelatin microspheres dispersed with bone morphogenetic protein, and the outer coating layer covered by the inner core layer is mainly composed of calcium alginate. The core-shell structure slow-release microsphere is a spherical body with a smooth surface, and the core-shell structure slow-release microsphere has a diameter of 71.50-156.27 μm and an average particle diameter of 108 μm. The drug loading amount of bone morphogenetic protein per milligram of the core-shell sustained-release microspheres of this embodiment is 29.32 micrograms.

[0054] The preparation method of the BMP-loaded gelatin-calcium alginate core-shell structure sustained-re...

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Abstract

A gelatin-calcium alginate core-shell structure sustained release microsphere loaded with bone morphogenetic protein (BMP) sequentially comprises an inner core layer and an outer wrapping layer from interior to exterior. The inner core layer is mainly composed of gelatin microspheres on which BMP is evenly dispersed, and the outer wrapping layer wrapping the inner core layer is mainly made of calcium alginate. The preparation of the sustained release microsphere comprises two modes. The first mode is that firstly, blank gelatin microspheres are prepared and then mixed with the calcium alginate to prepare a gelatin / sodium alginate blank core-shell structure sustained release microsphere, finally, the BMP is added, and the gelatin-calcium alginate core-shell structure sustained release microsphere loaded with the BMP is obtained. The second mode is that firstly, gelatin microspheres loaded with BMP are prepared and then mixed with sodium alginate to obtain the gelatin-calcium alginate core-shell structure sustained release microsphere loaded with the BMP. The product has the advantages that the sustained release effect is good, the side effect is slight, the cost is low, and no toxic or side effect is caused.

Description

technical field [0001] The invention belongs to the technical field of orthopedic materials and its preparation, and specifically relates to a slow-release microsphere whose main material is gelatin / calcium alginate with a core-shell structure to coat an active ingredient and a preparation method thereof. Background technique [0002] Bone defect and nonunion are one of the thorny problems in orthopedics, and avascular necrosis of the femoral head is one of the difficulties and hot spots in orthopedics clinical practice. For avascular necrosis of the femoral head, the traditional treatment method is surgery, but most of the surgery is at the cost of joint disuse, and artificial joint replacement has to be used. However, for young patients, the service life of artificial joints cannot meet the needs of patients. requirements. Improper or untimely treatment of avascular necrosis of the femoral head will lead to the collapse, deformation and traumatic arthritis of the femoral ...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/22A61L27/20A61L27/54A61L27/58
Inventor 雷霆肖涛赵蕊刘立宏于澍李专郭晓柠
Owner CENT SOUTH UNIV
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