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Construction method for clinic information quantification system

A construction method and clinical information technology, applied in informatics, medical informatics, medical automated diagnosis, etc., can solve the problems of restricting wide application and differences in evaluation effects, and achieve evaluation performance optimization, quantitative evaluation performance optimization, and easy promotion and the effect of communication

Inactive Publication Date: 2016-12-14
ZHEJIANG UNIV
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Problems solved by technology

2008 Santiago Tremoulet et al [4] A retrospective analysis of 362 cases of KD from 1998 to 2006 showed that the Egami quantitative method was used to evaluate the sensitivity of IVIGR to only 38.3%, and the specificity was 83.85%. Therefore, a new quantitative method was established to evaluate the sensitivity of IVIGR to 73.3%, and the specificity was 61.9%. The effect is different, the sensitivity of the Caucasian population is 81.3%, while the sensitivity of the Asian population is 66.7%, while the quantification system rod ratio and Hbz integral limit its wide application
However, methods for the quantification of persistent CAL and convalescent CAA in KD are still unreported

Method used

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  • Construction method for clinic information quantification system
  • Construction method for clinic information quantification system

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for constructing a quantitative system is provided, which is realized through the following steps:

[0032] (1) Collect the quantitative indicators of children with KD, including basic clinical data and routine laboratory examination results, and coronary follow-up data within one month of onset; specifically include the gender, age, number of days of fever, time of gamma therapy, and gamma therapy Efficacy, blood routine, CRP, erythrocyte sedimentation rate, blood biochemical liver function and electrolytes, echocardiography and coronary artery examination results;

[0033] (2) The non-parametric rank sum test was used for the comparison of count data, and the chi-square test was used for the comparison of measurement data. The parameters with differences in single factor analysis were entered into multi-factor logistic regression analysis, and the OR value was calculated. There was a statistical difference at P<0.05;

[0034] (3) The censored value was determ...

Embodiment 2

[0044] 2318 cases of Kawasaki disease were divided into gamma globulin-response group and gamma globulin-non-responsive group according to gamma globule resistance; compared the indicators between the two groups, the differences were entered into multi-factor logistic regression analysis, and the indicators with statistical differences were further quantitatively analyzed for OR Value, the quantitative system of gamma resistance can be obtained. as table 1

[0045] Table 1 IVIGR quantification system

[0046]

[0047] Hosmer and Lemeshow Test: P=0.193

Embodiment 3

[0049] The child, male, 5 months old, on the 8th day of fever, has not been treated with gamma balls, the blood routine showed that the erythrocyte sedimentation rate was 85mm / h, NE 80%, LY 10%, MO 6%, EO 3%, Plt 450×10 9 / L, blood biochemistry showed ALB 34.7g / L, γ-glutamyl transpeptidase 45U / L, sodium 134mmol / L;

[0050] Based on our quantitative approach, the following assessments can be made:

[0051] The probability of IVIGR in the overall sample is 0.143, and the probability of IVIGR in this child is 0.344 (0.127-0.654);

[0052] The probability of CAL in the acute and subacute stages of the overall sample is 0.27, and the incidence rate of this child is 0.437 (0.307-0.577);

[0053] The probability of persistent CAL in the recovery period of the overall sample is 0.137. If the child has IVIGR, the probability of the child’s persistent CAL is 0.342 (0.231-0.474). If the child’s IVIG treatment is effective, the probability of the child’s persistent CAL is 0.193 ( 0.139-...

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Abstract

The invention provides a construction method for a clinic information quantification system. Clinic common parameters such as clinic essential characteristics of KD child patients, blood routine examination indexes and blood biochemical indexes as quantification indexes; a quantification method for assessing IVIG resistance, acute and sub-acute coronary artery lesions, coronary artery continuous lesions and recovery phase coronary artery aneurysms is established through the multi-factor logistic regression analysis method; the probability of occurrence of IVIG resistance and coronary artery lesions of the KD child patients and an assessment result (area under the curve, sensitivity and specificity) can be obtained, and then clinic treatment is directed, and follow-up visit is performed. The prediction efficiency for IVIGR of the quantification method is optimized obviously in comparison with the conventional methods; the quantification method predicts KD recovery phase coronary artery continuous lesions and recovery phase coronary artery aneurysms; the clinic parameters required by the quantification method come from the clinic essential characteristics, the blood routine examination indexes and the blood biochemical indexes, thereby facilitating application in primary hospital and exchange and promotion.

Description

technical field [0001] The invention belongs to the medical field, and relates to a method for quantifying clinical information and the establishment of a quantification system, in particular to a method for building a quantification system for clinical information. Background technique [0002] Kawasaki disease (KD) is an acute self-limiting febrile disease with systemic vasculitis as the main lesion, mainly involving small and medium arteries, especially coronary arteries. KD mostly occurs in children under 5 years old, and the common complication is coronary artery lesion (Coronary arteries lesions, CAL), which has replaced rheumatic fever as the first cause of acquired heart disease in children. [0003] Gamma resistance (IVIG resistance, IVIGR) and CAL are KD research hotspots. In the past, some scholars reported the following reports on the clinical information quantification methods of IVIGR and CAL. In 2006 Egami et al. [1] It is reported that the quantitative sys...

Claims

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Application Information

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IPC IPC(8): G06F19/00
CPCG06F19/324G16H50/20
Inventor 龚方戚花旺
Owner ZHEJIANG UNIV
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