Azithromycin granule and preparation method thereof
A technology for azithromycin and granules, applied in the field of azithromycin granules and its preparation, can solve the problems of low dissolution and poor solubility of preparations, achieve good dissolution, improve poor solubility, and have high practical value
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[0028] Azithromycin Granule Specification: 0.1g
[0029] 1. Formula:
[0030] Azithromycin 100g, sucrose 400g, pregelatinized starch 125g, sodium starch glycolate 150g, mannitol 150g, stevia 75g, ethanol amount, orange flavor 0.83g
[0031] 2. Preparation process:
[0032] After mixing azithromycin, sucrose, pregelatinized starch, carboxymethyl starch sodium, mannitol, and stevioside evenly, use 80% ethanol solution to make a soft material, and the soft material is passed through a 12-mesh sieve to make wet granules, and the wet granules are boiled or oven-dried Drying, after the granules are dried, collect the granules between 12 and 60 meshes, add orange flavor and mix evenly, and pack the granules, about 1g per bag (containing 0.1g of azithromycin).
[0033] The finished product of azithromycin granules is inspected according to the second part of the Chinese Pharmacopoeia 2010 edition, and all should meet the requirements.
[0034] Inspection items include: character, i...
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