Novel hydroxychloroquine eutectic crystal, and preparation method, content determination method and application thereof
A hydroxychloroquine and crystallization technology, applied in the field of hydroxychloroquine new co-crystal and preparation thereof, can solve problems such as quantitative analysis of unfavorable hydroxychloroquine salt compounds, difficulties in industrial production and storage, and achieve low hygroscopicity and tabletability, Good linear relationship and less side effects
Pending Publication Date: 2022-04-12
SOUTH CHINA UNIV OF TECH
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The invention provides a novel hydroxychloroquine eutectic as well as a preparation method, a content determination method and application thereof. The novel hydroxychloroquine eutectic comprises a eutectic formed by hydroxychloroquine and 4-dimethylaminopyridine in a molar ratio of 2: 1. Compared with hydroxychloroquine, the novel hydroxychloroquine eutectic has higher dissolution rate and lower hygroscopicity compared with forms such as sulfate, phosphate and the like of hydroxychloroquine, the novel hydroxychloroquine eutectic can be prepared by various simple methods, and the novel hydroxychloroquine eutectic pharmaceutical composition has better dissolution rate, lower hygroscopicity and tabletting property, and can be used for preparing the pharmaceutical composition for preparing the hydroxychloroquine eutectic. And a novel hydroxychloroquine eutectic improved preparation with better curative effect and smaller side effect can be developed. The content determination method disclosed by the invention can be used for simultaneously and quantitatively determining the hydroxychloroquine and the 4-dimethylaminopyridine, and has the advantages of simplicity, rapidness, accuracy, reliability and good linear relationship in a high-concentration range.
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