Escketamine hydrochloride tablet and preparation method thereof
A technology of esketamine hydrochloride tablets and esketamine hydrochloride, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations with non-active ingredients, etc., can solve the problems of poor powder fluidity, easy to cause splinter, large difference in tablet weight, etc. , to achieve the effect of low breakage rate, improved production efficiency and good dissolution rate
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[0037] Example 1
[0038] It should be noted that the following detailed description is illustrative and is intended to provide a further description of the present application. All techniques and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art of the present application.
[0039] In order to make it possible to understand the technical solution of the present application more clearly, the technical solution of the present application will be described in detail below in conjunction with the specific embodiments.
[0040] The test materials used in the embodiments of the present invention are all conventional test materials in the art, and they can be purchased through commercial channels.
[0041] Example 1:
[0042] 1. Raw material components:
[0043] 14.0 grams of hydrochloride, 48.8 grams of lactose, 1 glycide K30 6 g, microcrystalline cellulose, 10 grams of mannitol, 0.14 grams of red silicon oxide, 0.06 grams o...
Example Embodiment
[0048] Example 2:
[0049] 1. Raw material components:
[0050]14.0 grams of hydrochloride, 40 grams of lactose, 1 glycide K30 10 grams, microcrystalline cellulose, 21 grams of mannitol, 0.14 grams of red silty iron oxide, 0.06 grams of yellow oxide, 1 gram of stearate.
[0051] 2. Preparation Process:
[0052] Preparation process as in Example 1.
Example Embodiment
[0053] Example 3:
[0054] 1. Raw material components:
[0055] 14.0 g of hydrochloride, 53.8 grams of lactose, 1 glycide K30 3 grams, microcrystalline cellulose, 5 grams of mannitol, 0.14 grams of red silicon oxide, 0.06 grams of yellow oxide, 1 gram of magnesium stearate.
[0056] 2. Preparation Process:
[0057] Preparation process as in Example 1.
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