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Applications of marine mangrove plant Acanthus ilicifolius L extract product in preparing drugs used for treating Alzheimer's disease

A mangrove plant, a technology for Alzheimer's disease, which is applied in the field of natural medicine preparation, can solve problems such as inability to treat disease progression, and achieve excellent anti-senile dementia effect.

Active Publication Date: 2017-01-04
SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs are widely used, most of them can only relieve symptoms and improve the patient's cognition, and cannot be used to treat or prevent the progression of the disease

Method used

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  • Applications of marine mangrove plant Acanthus ilicifolius L extract product in preparing drugs used for treating Alzheimer's disease
  • Applications of marine mangrove plant Acanthus ilicifolius L extract product in preparing drugs used for treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of rat bougainvillea extract 1

[0019] Take 5 kg of the leaves of the mouse bougainvillea (purchased from Guangzhou Mangrove Seedling Base) and put it in the extractor, add 100 L of ethanol with a concentration of 70% for reflux extraction, extract twice, each extraction time is 2 hours, combine the extracts, and concentrate under reduced pressure Until there is no alcohol smell, centrifuge to obtain the supernatant. Pass the supernatant through a chromatographic column filled with 7.5 L of polyamide packing (model: PA66, specification: 30-60 mesh) suspended in 5% acetic acid aqueous solution, and then elute three columns with water and 10% ethanol in sequence volume, and then eluted with 70% ethanol for 5 column volumes, collected the 70% ethanol segment, and concentrated under reduced pressure to obtain 370 g of arboreal extract.

Embodiment 2

[0020] Embodiment 2: the preparation of rat bougainvillea extract 2

[0021] Take 5 kg of the medicinal material of Bougainvillea japonica, put it in the extractor, add 80L of 80% ethanol to reflux extraction, extract 3 times, each extraction time is 3 hours, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, centrifuge to obtain the supernatant liquid. Pass the supernatant through a chromatographic column filled with 10L of polyamide filler (model: PA66, specification: 30-60 mesh) suspended in 5% acetic acid aqueous solution, and then eluted with water and 10% ethanol in sequence for 3 column volumes , and then eluted with 70% ethanol for 5 column volumes, collected the 70% ethanol segment, concentrated under reduced pressure, and obtained 390 g of the extract of Bougainvillea japonica.

Embodiment 3

[0022] Embodiment 3: the preparation of rat bougainvillea extract 3

[0023] Take 5 kg of the medicinal material of Bougainvillea japonica, put it in the extractor, add 80L of 80% ethanol to reflux extraction, extract 3 times, each extraction time is 3 hours, combine the extracts, concentrate under reduced pressure until there is no alcohol smell, centrifuge to obtain the supernatant liquid. The supernatant was passed through a chromatographic column filled with 10L polyamide filler (model: PA66, specification: 30-60 mesh) suspended in water as a solvent, and then eluted with water and 10% ethanol for 3 column volumes, and then The 5 column volumes were eluted with 70% ethanol, and the 70% ethanol segment was collected and concentrated under reduced pressure to obtain 338 g of arboreal extract.

[0024] Chinese patent application 200810071371.3 discloses the "extraction method of total flavonoids of the medicinal mangrove plant Bougainvillea", and Chinese patent application 2...

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Abstract

The invention provides applications of a marine mangrove plant Acanthus ilicifolius L extract product in preparing drugs used for treating and / or preventing Alzheimer's disease. The marine mangrove plant Acanthus ilicifolius L extract product is prepared via following steps: 1, Acanthus ilicifolius L leaves are delivered into an extractor, and are subjected to reflux extraction with an ethanol solution with a concentration ranging from 30% to 95%, obtained extracting solution is mixed, and is subjected to vacuum concentration until no ethanol smell is observed, an obtained mixture is subjected to centrifugation, and a supernate is collected, wherein the weight-to-volume ratio of the Acanthus ilicifolius L leaves to the solvent is controlled to be 1:10-30, extraction time is controlled to be 1 to 3h, and extraction is carried out for 1 to 3 times; 2, the supernate obtained in step is delivered through a polyamide chromatographic column, elution of three column volumes is carried out with water and 10% ethanol respectively, elution of five column volumes is carried out with 70% ethanol, and a 70% ethanol fraction is collected, and is subjected to vacuum concentration so as to obtain the marine mangrove plant Acanthus ilicifolius L extract product, wherein the polyamide chromatographic column is filled with 5% acetic acid aqueous solution suspended polyamide, the using amount of the polyamide filling material accounts for 1 to 2 times of the weight amount of the Acanthus ilicifolius L leaves.

Description

technical field [0001] The invention relates to the field of natural medicine preparation, in particular to the new application of plant extracts. Background technique [0002] Alzheimer's disease (also known as Alzheimer's disease, Alzheimer's Disease, referred to as AD), is a progressive and fatal neurodegenerative disease, which can be clinically manifested as continuous deterioration of cognitive and memory functions, and progressive daily life ability. Decreased, and may have a variety of neuropsychiatric symptoms and behavioral disorders. According to relevant data, as early as 2006, about 26 million people around the world suffered from Alzheimer's disease, and by 2050 it is estimated that 1 in 85 people worldwide will suffer from the disease. According to incomplete statistics, there are currently about 5 million Alzheimer's patients in my country, accounting for a quarter of the world's total. With the prolongation of human life expectancy, the incidence of this d...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61P25/28
Inventor 谭道鹏冯贻东于琳王春宴曾伟珍
Owner SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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