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A kind of Geshanxiao extract, its preparation method and its application in lowering blood sugar

A technology of Geshanxiao and extract, applied in the field of medicine, can solve the problems of liver and kidney injury, aggravating the burden on the heart, and increasing the mortality rate of cardiovascular diseases.

Active Publication Date: 2021-12-24
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the hypoglycemic effect of Western medicine is relatively obvious, and can effectively control blood sugar. However, long-term use has relatively serious side effects, such as sulfonylurea drugs, which are prone to liver and kidney damage, hypoglycemia, nausea, headache, dizziness, and blurred vision. , increase the side effects of cardiovascular disease mortality; biguanides are likely to cause nausea and increase the burden on the heart; thiazolidinediones are likely to damage the liver and cause cancer

Method used

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  • A kind of Geshanxiao extract, its preparation method and its application in lowering blood sugar
  • A kind of Geshanxiao extract, its preparation method and its application in lowering blood sugar
  • A kind of Geshanxiao extract, its preparation method and its application in lowering blood sugar

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Experimental program
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Effect test

Embodiment 1

[0018] A preparation method of Geshanxiao ethyl acetate extract, comprising the following steps:

[0019] Take Geshanxiao roots, wash them, dry them in the sun and grind them to 100 mesh fine powder. 1 kg of Geshanxiao root tuber powder, cold-soaked in 75% ethanol for 3 times each time for a week, concentrated under reduced pressure to remove ethanol to obtain extract, dissolved in 3-5 L of water, degreased by industrial petroleum ether, and then industrially distilled ethyl acetate 3-5 L of esters were extracted 3 times respectively, the ethyl acetate extracts were combined, and the ethyl acetate was removed by concentration under reduced pressure to obtain 48.6 g of Geshanxiao ethyl acetate extract, namely Geshanxiao extract.

Embodiment 2

[0021] A preparation method of Geshanxiao ethyl acetate extract, comprising the following steps:

[0022] Take Geshanxiao roots, wash them, dry them in the sun and grind them into fine powder of 120 mesh. Geshanxiao root tuber powder 1 kg, 75% ethanol heating reflux extraction 3 times for 2 hours each time, concentrated under reduced pressure to remove ethanol to obtain extract, add 3-5 L of water to dissolve the extract, degrease with industrial petroleum ether, and then industrial re-steam 3-5 L of ethyl acetate were extracted three times respectively, the ethyl acetate extracts were combined, and the ethyl acetate was removed by concentration under reduced pressure to obtain 52.1 g of Geshanxiao ethyl acetate extract, that is, Geshanxiao extract.

Embodiment 3

[0024] A preparation method of Geshanxiao ethyl acetate extract, comprising the following steps:

[0025] Take Geshanxiao roots and wash them, then dry them and grind them into fine powder of 110 mesh. Geshanxiao root tuber powder 1 kg, 95% ethanol heating reflux extraction 3 times for 2 hours each time, concentrated under reduced pressure to remove ethanol to obtain extract, add 3-5 L of water to dissolve the extract, degrease with industrial petroleum ether, and then industrial re-steam 3-5 L of ethyl acetate were extracted 3 times respectively, the ethyl acetate extracts were combined, and the ethyl acetate was removed by concentration under reduced pressure to obtain 38.6 g of Geshanxiao ethyl acetate extract, that is, Geshanxiao extract.

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Abstract

The invention discloses a Geshanxiao extract, its preparation method and its application in lowering blood sugar, which is based on C 21 Steroidal saponins and aglycon as the main components of the extract, of which: C 21 Steroidal saponins and aglycones as the main components of the extract are kudatine or qingyangshen aglycone. The preparation method is as follows: take Geshanxiao root tubers and wash them, dry them in the sun and crush them into fine powder; soak Geshanxiao root tubers in an organic solvent or heat them to reflux, then concentrate under reduced pressure to remove the organic solvents to obtain extracts, and add water to dissolve the extracts and remove them. Grease, then extracted with ethyl acetate, the ethyl acetate extracts were combined, and concentrated under reduced pressure to remove ethyl acetate to obtain the ethyl acetate extract of Geshanxiao, that is, Geshanxiao extract. The invention can lower blood sugar.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Geshanxiao extract, a preparation method of the Geshanxiao extract, and an application in lowering blood sugar. Background technique [0002] Diabetes is a common endocrine and metabolic disease with a high incidence rate. Its incidence rate is increasing year by year. It has become a common and frequently-occurring disease worldwide that endangers human health. It is listed as one of the three major diseases along with cardiovascular and cerebrovascular diseases and tumor diseases. one. The prevalence of diabetes is increasing year by year, and it is expected to increase to 380 million in 2025; the incidence of diabetes in China ranks first in the world, and about one tenth of the population suffers from hyperglycemia or diabetes. Type 1 diabetes is caused by congenital insulin deficiency; type 2 diabetes is caused by defects in insulin secretion and insulin resi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/27A61P3/10
CPCA61K36/27A61K2236/55A61K2236/39A61K2236/333A61K2236/15
Inventor 黄烈军郝小江李玲顾玮苑春茂高丽辉
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI