Novel catgut degreasing technological method

A new technology, the technology of sheep gut, is applied in the field of biological sutures, which can solve the problems of short time to maintain the tension strength, easy degradation of the thread body, and many fat spots in the casing material, so as to improve the degreasing efficiency and enhance the tensile strength. Effect

Inactive Publication Date: 2017-01-11
程庭润
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the 1980s, domestically-made medical absorbable sutures (medical sheep catgut), which are widely used in clinical operations, can become a standout in the series of surgical sutures, but the fly in the ointment is that there are many fat spots in the casing material. Affects product structure polymerization and thread appearance, thread body is easy to degrade, and maintains tensile strength for a short time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] It includes the following steps (1) Cleaning: select fresh sheep intestines and cattle casings, wash the blood on the surface of the casings with water, and then remove the mucous membrane, serosa, and mesentery in the casings; (2) Freeze: remove the surface moisture from the cleaned casings Then put it into the cold storage, the temperature of the cold storage is below minus 60°C, and the freezing time is 20-24h; (3) Freeze-drying: freeze-dry at minus 40-45°C for 48 hours, wrap it with filter paper and put it into the extractor; (4) Degreasing: After freeze-drying the casings, put them in sodium hydroxide solution at 18°C ​​for 10 hours, then add petroleum ether for 12 hours.

Embodiment 2

[0018] It includes the following steps (1) Cleaning: select fresh sheep intestines and cattle casings, wash the blood on the surface of the casings with water, and then remove the mucous membrane, serosa, and mesentery in the casings; (2) Freeze: remove the surface moisture from the cleaned casings Then put it into the cold storage, the temperature of the cold storage is below minus 60°C, and the freezing time is 20-24h; (3) Freeze-drying: freeze-dry at minus 40-45°C for 48 hours, wrap it with filter paper and put it into the extractor; (4) Degreasing: After freeze-drying the casings, put them in sodium carbonate solution at 18°C ​​for 12 hours, then add petroleum ether for 12 hours.

Embodiment 3

[0020] It includes the following steps (1) Cleaning: select fresh sheep intestines and cattle casings, wash the blood on the surface of the casings with water, and then remove the mucous membrane, serosa, and mesentery in the casings; (2) Freeze: remove the surface moisture from the cleaned casings Then put it into the cold storage, the temperature of the cold storage is below minus 60°C, and the freezing time is 20-24h; (3) Freeze-drying: freeze-dry at minus 40-45°C for 48 hours, wrap it with filter paper and put it into the extractor; (4) Degreasing: After freeze-drying the casings, put them in potassium carbonate solution at 18°C ​​for 8 hours, then add petroleum ether for 12 hours.

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PUM

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Abstract

The invention belongs to the field of biological suture lines and particularly relates to a novel catgut degreasing technological method. The novel catgut degreasing technological method includes the following steps of 1, cleaning, wherein a fresh sheep intestine and a cattle casing are selected, blood-containing water on the surface of the casing is washed away with clean water, and then mucosa, serosa and mesentery in the casing are removed; 2, freezing, wherein the cleaned casing is placed in a refrigeration house after surface water of the casing is removed, the temperature of the refrigeration house is below -60 DEG C, and the refrigeration time ranges from 20 h to 24 h; 3, freeze-drying, wherein freeze-drying is carried out for 48 hours at the temperature of -40 DEG C to -45 DEG C, the casing is wrapped by filter paper, and the casing is put in an extractor; 4, degreasing, wherein the freeze-dried casing is put in alkali liquor at the temperature of 18 DEG C to be treated for 8-12 h, and then a degreasing agent is added for treatment for 12 h. Degreasing efficiency is improved, the degreasing rate reaches 98%, no fat white dot exists on the appearance of a catgut body, and anti-tensile strength is enhanced by 20%.

Description

[0001] (1) Technical field [0002] The invention belongs to the field of biological sutures, in particular to a new process for degreasing sheep catgut. [0003] (2) Background technology [0004] Since the 1980s, domestically-made medical absorbable sutures (medical sheep catgut), which are widely used in clinical operations, can become a standout in the series of surgical sutures, but the fly in the ointment is that there are many fat spots in the casing material. Affect product structure polymerization and thread body appearance, thread body is easy to degrade, and maintain tension strength for a short time. In this context, it is necessary to develop a new process for degreasing sheep catgut. [0005] (3) Contents of the invention [0006] In order to make up for the deficiencies of the prior art, the invention provides a new process for degreasing sheep catgut. [0007] The present invention is achieved through the following technical solutions: [0008] A new technol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/08
CPCA61L17/08
Inventor 程庭润刘畅程光起王凤云
Owner 程庭润
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