Unlock instant, AI-driven research and patent intelligence for your innovation.

Industrialized preparation method of o-carboxymethyl chitosan

A technology of carboxymethyl chitosan and chitosan, which is applied in the field of industrial preparation of O-carboxymethyl chitosan, can solve problems such as toxic organic compounds, and achieve the effects of preventing oxidation, ensuring output, and ensuring quality

Active Publication Date: 2019-05-10
浙江澳兴生物科技有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there are no relevant patents for the large-scale industrial production of carboxymethyl chitosan. The existing carboxymethyl chitosan patents are only in the relevant small-scale test stage, and the substitution position is basically at the N position, or at the N position and the O position. In addition, toxic organic compounds are used in the reaction

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Industrialized preparation method of o-carboxymethyl chitosan
  • Industrialized preparation method of o-carboxymethyl chitosan
  • Industrialized preparation method of o-carboxymethyl chitosan

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038] The preparation method provided by the embodiment of the present invention includes the following steps:

[0039] S101, adding chitosan to the lye below 30°C to form a wet material.

[0040] Among them, the added chitosan is preferably chitosan made from crab shells with a fineness of more than 40 mesh after being crushed.

[0041] The proportion of chitosan in the wet material is 25% to 35%.

[0042] Of course, before adding chitosan, the lye must be prepared first. In this example, water and flake caustic soda are mixed in a mass ratio of 1:0.7 to 1:2, stirred to dissolve the alkali, and obtain Lye, and cool the lye to below 30°C.

[0043] S102: Put the wet material into a tank mixer, stir evenly to swell the chitosan, put it into a double-layer inner film bag, tie the mouth of the bag, and leave it for 5-10 hours.

[0044] S103: Put the double-layer inner film bag in a cold storage and freeze for 24 to 72 hours.

[0045] Among them, the freezing temperature is preferably -18°C,...

Embodiment 1

[0073] 1) Mix 100kg of flake caustic soda and 100kg purified water to make 1:1 lye. When the temperature of lye drops to 30℃, add 100kg of chitosan to the lye and mix thoroughly by tank mixer. Then pass through a 40-mesh sieve, put it into a double-layer inner film bag, tie the mouth of the bag, place it for 6 hours and then put it in a cold storage at -18°C for 48 hours.

[0074] 2) Put the frozen materials into the reaction kettle, add 800kg of isopropanol and vacuum pump into the reaction kettle, soak for 4 hours.

[0075] 3) Stir the soaked material for 30 minutes. During the stirring process, start the cooling system at the same time to ensure that the temperature in the kettle does not exceed 20°C.

[0076] 4) 120kg of chloroacetic acid and 40kg of ethanol above 95% are prepared into a chloroacetic acid ethanol solution and pumped into the metering tank.

[0077] 5) The chloroacetic acid ethanol solution in the measuring tank is slowly added dropwise to the reaction kettle, the ...

Embodiment 2

[0085] 1) Mix 100kg flake caustic soda and 110kg purified water into 1:1.1 lye. When the temperature of the lye drops to 30°C, add 100kg of chitosan to the lye and mix thoroughly with a tank mixer. Then pass through a 40-mesh sieve, put it into a double-layer inner film bag, and tie the mouth of the bag; after standing for 7 hours, put it in a cold storage at -18°C for 60 hours.

[0086] 2) Put the frozen materials into the reaction kettle, add 800kg of isopropanol to the reaction kettle under vacuum, and soak for 5 hours.

[0087] 3) Stir the soaked material for 30 minutes, and start the cooling system at the same time to ensure that the temperature in the kettle does not exceed 20°C.

[0088] 4) 120kg of chloroacetic acid and 40kg of ethanol above 95% are prepared into a chloroacetic acid ethanol solution and pumped into the metering tank.

[0089] 5) The chloroacetic acid ethanol solution in the metering tank is slowly added dropwise to the reaction kettle, the dropping rate is con...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The embodiment of the invention relate to an industrial preparation method of O-carboxymethyl chitosan. Chitosan is added into alkali liquor of the temperature below 30 DEG C, wet materials are formed, and refrigeration is carried out for 24-72 hours; isopropyl alcohol with the mass 2.5-3.5 times that of the wet materials is added, soaking is carried out for 4-6 hours, and stirring is carried out for 30 minutes; a chloroacetic acid and ethanol solution is dropwise added into the material liquid, and the temperature is controlled to be not larger than 50 DEG C; after all the chloroacetic acid and ethanol solution is dropwise added, the material liquid in a reaction still is subjected to heat preservation; the material liquid obtained after heat preservation is centrifugalized for 30 minutes and then put into the reaction still, ethanol with the mass three times that of the materials is added, and stirring is carried out; a 3%-8% hydrochloric acid solution is added, the pH is adjusted to range from 7.0 to 7.7, and centrifugalization is carried out for 30 minutes; ethanol is added, and soaking, stirring and centrifugalizing are carried out; the materials obtained after centrifugalization are put into the reaction still again, ethanol is added, and soaking, stirring and centrifugalizing are carried out; the materials obtained after centrifugalization are dried, smashed and screened, and O-carboxymethyl chitosan is obtained.

Description

Technical field [0001] The invention relates to the technical field of medical processing technology, in particular to an industrialized preparation method of O-carboxymethyl chitosan. Background technique [0002] O-carboxymethyl chitosan, also known as O-carboxymethyl chitosan sodium, its English name is Carboxymethyl Chitosan, and its molecular structure is: [0003] [0004] O-carboxymethyl chitosan is a water-soluble chitosan derivative, which is the product of chitosan localized carboxymethylation. Because it not only retains the advantages of chitosan, but also greatly improves the water solubility, it is of great significance in medicine, chemical industry, environmental protection, and health care products. And its stable properties, antibacterial and anti-infection, lipid-lowering and prevention and treatment of arteriosclerosis and other pharmacological effects make it play a greater role in the daily life of human beings in the future. [0005] Carboxymethyl chitosan ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 詹小远张福明金仙花
Owner 浙江澳兴生物科技有限公司