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A method for infrared degradation of marine sulfated polysaccharides

A sulfated polysaccharide and marine technology, applied in the field of biological preparations, achieves the effects of simple equipment, reduced purification process, and low production costs

Active Publication Date: 2019-03-26
JIMEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there has been no application of related technologies in the preparation of low molecular weight polysaccharides, especially in the preparation of low molecular weight marine sulfated polysaccharides

Method used

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  • A method for infrared degradation of marine sulfated polysaccharides
  • A method for infrared degradation of marine sulfated polysaccharides
  • A method for infrared degradation of marine sulfated polysaccharides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Spread 100g of kelp fucoidan dry powder on a clean stainless steel tray with a thickness of 0.1cm, and then put it into a drying box equipped with a 2200w infrared lamp. The height of the infrared lamp from the kelp fucoidan powder is 10cm. Turn on the switch of the infrared drying oven and heat for 2h, 4h, 6h, 8h, 10h, 12h, 14h, 16h, and the relative viscosity values ​​are 84.3%, 65.2%, 61.3%, 57.6%, 44.8%, 36.2%, 21.4% Low molecular weight kelp fucoidan dry powder. Such as figure 1 shown.

Embodiment 2

[0021] Spread 100g of sea cucumber fucoidan dry powder on a clean stainless steel tray with a thickness of 0.15cm, and then put it into a drying box equipped with a 2200w infrared lamp. The height of the infrared lamp from the sea cucumber fucoidan powder is 20cm. Turn on the switch of the infrared drying oven and heat for 2h, 4h, 6h, 8h, 10h, 12h, 14h, 16h, and the relative viscosity values ​​are 81.7%, 59.2%, 55.3%, 50.2%, 42.1%, 33.5%, 18.2% Low molecular weight sea cucumber fucoidan dry powder.

Embodiment 3

[0023] Spread 100g of shark chondroitin sulfate dry powder on a clean stainless steel tray with a thickness of 0.2cm, and then put it into a drying box equipped with a 2200w infrared lamp. The height of the infrared lamp from the shark chondroitin sulfate powder is 30cm. Turn on the infrared Drying box switch, heating 2h, 4h, 6h, 8h, 10h, 12h, 14h, 16h, that is, the relative viscosity values ​​are 85.6%, 70.1%, 65.2%, 60.4%, 46.3%, 39.9%, 26.4% low Molecular shark chondroitin sulfate dry powder.

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Abstract

The invention discloses an infrared degradation method for ocean sulphated polysaccharide. The method comprises the following steps that ocean sulphated polysaccharide dry powder is laid on a clean stainless steel tray, the thickness ranges from 0.1 cm to 0.2 cm, the ocean sulphated polysaccharide dry powder is placed in a drying box containing a 2,200w infrared lamp to be heated for 2 h to 16 h, the height of the infrared lamp away from the ocean sulphated polysaccharide powder ranges from 10 cm to 30 cm, and low-molecular weight ocean sulphated polysaccharide dry powder is obtained. The infrared degradation method has the advantages that no chemical or biological reagent is introduced, the method is environmentally friendly, and subsequent purifying processes are reduced; the ocean sulphated polysaccharide is degraded in the state of dry powder, limit of polysaccharide solubleness is avoided, production efficiency is high, and dissolving, drying and other unit operation are reduced; operation is easy and convenient, equipment is simple, and the production cost is low; good biological activity is achieved, low-molecular weight fucoidan obtained after infrared degradation is carried out for 16 h shows good bacteriostatic activity, and the bacteriostasis rate of the low-molecular weight fucoidan with the concentration of 1.0 wt% on escherichia coli reaches 100%.

Description

technical field [0001] The invention belongs to the field of biological preparations, in particular to a preparation method of active low-molecular-weight marine sulfated polysaccharides. Background technique [0002] Natural marine sulfated polysaccharides have a high degree of polymerization and high viscosity, resulting in poor absorption by the human body and low biological activity. However, after the natural marine sulfated polysaccharides are degraded into low-molecular-weight marine sulfated polysaccharides, they have various biological activities such as anticoagulant, anticancer, and antiviral, and can be used in the development of biomedicine, health food and other products. For example, hydrolyzed fucoidan (390-2200kDa) showed stronger anticancer activity than natural fucoidan (5100kDa) (Chen et al., 2008); Wang Ying et al. Alcoidan acts on the animal model of oxidative damage in mice, and its antioxidant capacity is significantly higher than that of undegraded ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
CPCC08B37/0069
Inventor 刘翼翔曹敏杰刘光明
Owner JIMEI UNIV
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