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Quality check method of children's granules for clearing heat from throat

A technology for granule quality and inspection methods, which can be applied to measuring devices, material inspection products, weighing by removing certain components, etc., and can solve problems such as the lack of applicable Xiaoqingyan granule quality inspection methods

Inactive Publication Date: 2017-02-22
贵州中医药大学第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no quality testing method suitable for Xiaoqingyan Granules. In order to ensure the stability and curative effect of the preparation, it is necessary to study the quality testing of the drug

Method used

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  • Quality check method of children's granules for clearing heat from throat
  • Quality check method of children's granules for clearing heat from throat
  • Quality check method of children's granules for clearing heat from throat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The prescription Xiaoqingyan granule is made from the following raw materials: 390.6 g of mulberry leaves, 390.6 g of Radix isatidis, 260.4 g of Shegan, 260.4 g of Scrophulariae scrophulariae, 260.4 g of licorice, 2.5 mL of mint oil, and 433-550 g of soluble starch, making 1000 g.

[0043] The preparation method is to add 10 times the amount of water to the prescription Wuwei decoction pieces (add 12.5 times the water for the first decoction), soak for 1 hour, and decoct 3 times, 0.5 hours each time. Combine the decoction and filter. The filtrate is concentrated under normal pressure to a thick extract with a relative density of 1.35~1.40 (60°C), and dried under reduced pressure at 80°C. Grind the dry paste into fine powder (through a 60-mesh sieve) and mix it with 433-550 g of soluble starch evenly, make a soft material with 95% ethanol in an appropriate amount, granulate with a 14-mesh sieve, dry at 60 °C, granulate with a 12-mesh sieve, and spray into the mint oil 2...

Embodiment 2

[0061] 1. Identification

[0062] This product is composed of five flavors of Chinese medicinal materials such as mulberry leaves and isatis root, which are extracted and refined, and the ingredients are relatively complex. We have carried out experimental research on the identification methods of the components of various Chinese medicinal materials, and established a TLC identification method for Radix Radix, Scrophulariaceae, and Shegan.

[0063] (1) Identification of Radix isatidis: Take 0.5 g of this preparation, add 20 mL of dilute ethanol, heat to reflux for 20 minutes, filter, evaporate the filtrate to dryness, add 1 mL of dilute ethanol to dissolve the residue, and use it as the test solution. Take 0.5 g of the negative mock preparation lacking Radix isatidis, and prepare the negative control solution in the same way. Another 0.5 g of Radix isatidis reference drug was taken, and the reference drug solution was prepared in the same way. According to the "Chinese Phar...

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Abstract

The invention discloses a quality check method of children's granules for clearing heat from throat. 1000g of the children's granules are prepared from the following crude drugs by quantity parts: 390.6g of mulberry leaves, 390.6g of radix isatidis, 260.4g of rhizoma belamcandae, 260.4g of radix scrophulariae, 260.4g of liquorice, 2.5mL of dementholized peppermint oil and 433-550g of soluble starch. The quality check method of the children's granules for clearing heat from throat comprises the following items: character: the product is the granules, is claybank to tawny and has fragrant smell and slightly sweet and slightly bitter taste; identification: a thin layer chromatography is adopted for identification; check: the check complies with the following various relevant provisions for the granules (Chinese Pharmacopoeia (General Principles 0104)); determination of extract: the determination comprises content determination of dilute ethanol extract; content determination: the content determination comprises content determination of tectoridin. The method is taken as a standard for checking the children's granules for clearing heat from throat, so that the stability of the preparation can be excellently ensured, thereby ensuring the curative effect of the preparation.

Description

technical field [0001] The invention relates to a method for inspecting the quality of medicines, in particular to a method for inspecting the quality of Xiaoqingyan granules used for the treatment of sore throat caused by acute pharyngitis and upper respiratory tract infection. Background technique [0002] Xiaoqingyan Granule is a drug used for the treatment of sore throat caused by acute pharyngitis and upper respiratory tract infection. It is mainly used for the treatment of acute pharyngitis and sore throat caused by upper respiratory tract infection. For internal and external pathogens invading the throat, such as exogenous pathogenic factors, wind-heat and cold-dampness, temperature and pathogenic poison, internal injury diet, spicy decoction, internal phlegm heat, etc. Condensation of qi and blood, accumulated into poison, causing throat disorders, symptoms include sore throat, difficulty swallowing, extensive ulceration, dyspnea, itchy throat and cough, hoarse voice...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N5/04G01N30/02G01N30/06G01N33/15
CPCG01N5/04G01N30/02G01N30/06G01N30/90G01N33/15G01N2030/027G01N2030/062
Inventor 林英徐献梅蒋玲黄宜洲马克芹
Owner 贵州中医药大学第二附属医院
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