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External preparation

An external agent and chemical formula technology, which is applied in the direction of dressing preparations, skin care preparations, cosmetics, etc., can solve the problem of coloring over time and achieve the effect of inhibiting coloring

Inactive Publication Date: 2017-02-22
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, tranexamic acid has a problem of coloring over time when exposed to sunlight, high temperature, etc.
In addition, there is also a problem of coloring when tranexamic acid and sugar are used together

Method used

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  • External preparation
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preparation example Construction

[0092] The production method of the compound represented by formula (I) is not particularly limited. The production method of the compound represented by formula (I), for example, can prepare a derivative by condensing a compound having an amino group and a compound having a carboxyl group. The production method of the compound represented by formula (1) is not particularly limited. The compound represented by the formula (1) can be prepared, for example, by condensing the amino group of an amino acid with the carboxyl group of a fatty acid to prepare a derivative. The production method of the compound represented by formula (24) is not particularly limited. The method for producing the compound represented by the formula (24), for example, can be prepared by oxidizing urea to prepare a derivative.

[0093] The external preparation of this embodiment may be any of pharmaceuticals, quasi-drugs, or cosmetics. The external preparation of the present embodiment is preferably a ...

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PUM

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Abstract

Provided is an external preparation containing (A) tranexamic acid or a salt thereof, (B) a saccharide, and (C) a compound represented by formula (I) or a salt thereof. (In formula (I), Ra indicates a C7-19 linear alkyl group or a group represented by NRdRe, Rd and Re each independently indicate a hydrogen atom or optionally substituted alkyl group, Rb and Rc each independently indicate a hydrogen atom, optionally substituted alkyl group, or group represented by formula (II). Here, Rb and Rc may bond to each other to form a ring. Substituents are a hydroxyl group, carboxy group, alkyl group, or group represented by formula (III). In formula (II), Rf indicates a hydrogen atom or an alkyl group optionally substituted by a hydroxyl group.

Description

technical field [0001] The present invention relates to an external preparation. Background technique [0002] It is well known that tranexamic acid has a pigmentation inhibitory effect and the like, and is used in various cosmetics for whitening and the like. On the other hand, tranexamic acid has a problem of coloring over time under conditions such as exposure to sunlight and high temperature. In addition, when tranexamic acid and sugars are used together, there is also a problem of coloring. [0003] As a method for suppressing coloring when tranexamic acid and sugars are used together, for example, Patent Document 1 discloses a cosmetic composition characterized in that a composition containing tranexamic acid and sugars In, one or two or more selected from inorganic acids or their salts, organic acids or their salts, alcohols, vitamins or their derivatives, chelating agents, and plant, seaweed, or animal-derived components are added. [0004] prior art literature ...

Claims

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Application Information

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IPC IPC(8): A61K8/44A61K8/60A61K8/73A61Q19/02
CPCA61K8/44A61K8/60A61K8/73A61Q19/02
Inventor 藤田幸惠升田贤太
Owner ROHTO PHARM CO LTD