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Medicine that cures muscle atrophy after spinal cord injury and its application method

A technique for muscle atrophy and spinal cord injury, applied in the field of biomedicine to avoid atrophy and improve clinical neurological function

Inactive Publication Date: 2017-03-08
天津运三泽生物医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a drug for treating spinal cord injury muscle atrophy and its application method, aiming to solve the problem of whether angiotensin II receptor blockers can alleviate the skeletal muscle atrophy caused by spinal cord injury

Method used

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  • Medicine that cures muscle atrophy after spinal cord injury and its application method
  • Medicine that cures muscle atrophy after spinal cord injury and its application method
  • Medicine that cures muscle atrophy after spinal cord injury and its application method

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Embodiment Construction

[0018] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0019] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0020] Such as figure 1 As shown, the construction method of the angiotensin II receptor antagonist provided by the embodiments of the present invention for treating spinal cord injury muscle atrophy comprises the following steps:

[0021] S101: After intraperitoneal anesthesia with 10% chloral hydrate, the rats were placed in the prone position and fixed on the small animal operating table. A midline longitudinal incision was made on the back centered on T10, the skin and subcutaneou...

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Abstract

The invention discloses a medicine that cures muscle atrophy after spinal cord injury and its application method: the medicine that cures muscle atrophy after spinal cord injury is losartan. The application method is that losartan activates a signal pathway of IGF1 / Akt / mTOR and inhibits an expression of MuRF-1; A receptor blocking pharmacon of angiotensin II takes effect through activating the pathway of IGF-1 / Art / mTOR and inhibiting a ubiquotin-proteasomes system. The receptor blocking pharmacon of angiotensin II can improve the skeletal muscle atrophy after spinal cord injury of rats and may take effect through activating the pathway of IGF-1 / Akt / mTOR and inhibiting the ubiquitin-proteasomes system, which provides a part of basis for later clinical application and combined therapy.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a medicine for treating spinal cord injury muscle atrophy and an application method thereof. Background technique [0002] Spinal cord injury (spinal cord injury, SCI) is a serious central system disorder, leading to irreversible motor and sensory dysfunction. Muscle atrophy caused by spinal cord injury is a common clinical complication after spinal cord injury, which will lead to further loss of motor function, affect rehabilitation treatment, reduce recovery opportunities, increase bed rest time and the probability of other complications. At present, the treatment of muscle atrophy after spinal cord injury is mainly limited to the rehabilitation treatment in the late recovery period. At this time, the gene expression and protein phenotype in the muscle have often changed. In addition, the atrophied muscle often further affects the recovery process of the patient...

Claims

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Application Information

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IPC IPC(8): A61K31/4178A61P25/02A61P21/00
CPCA61K31/4178
Inventor 冯世庆魏志坚姚雪周先虎宁广智孔晓红周新福周恒星樊保佑李昂
Owner 天津运三泽生物医药科技有限公司
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