Combination medicine of hispiraceae bacteria and human immune globulin for injection

A technology of human immunoglobulin and immunoglobulin, which is applied in the directions of drug combination, medical raw materials derived from bacteria, and pharmaceutical formulations, etc., can solve the problems of complicated preparation, decreased treatment effect, unclear proportion of Lachnospiraceae, etc.

Pending Publication Date: 2022-04-26
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI +2
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Problems solved by technology

Hao Guo et al. reported that the mixture of 23 strains of Lachnospiraceae can be used to treat radiation damage, but the ratio between the 23 strains of Lachnospiraceae is unclear, the preparation is complicated, and as the abundance of Lachnospiraceae decreases, its therapeutic effect decreases (Guo H et al. -omics analyzes of radiation survivors identify radioprotective microbes and metabolites. Science. 2020 Oct 30; 370(6516):eaay9097.)

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  • Combination medicine of hispiraceae bacteria and human immune globulin for injection
  • Combination medicine of hispiraceae bacteria and human immune globulin for injection
  • Combination medicine of hispiraceae bacteria and human immune globulin for injection

Examples

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Embodiment 1

[0036] Example 1 Combined use of IVIg and Lachnospiraceae in the treatment of radiation injury

[0037] The Lachnospiraceae used in this example is Lachnospiraceae bacterium (ATCC BAA-2278).

[0038] 1. Method

[0039] 1.1, 5Gy whole body irradiation analysis of hematopoietic injury

[0040] 24 male mice were divided into 2 groups:

[0041] ①IVIg group, 12 rats;

[0042] ②12 rats in the IVIg+Lachnospiraceae group;

[0043] In the IVIg group, IVIg was intravenously injected once 5 minutes after whole body irradiation, and then injected IVIg twice a week for two weeks, each dose was 0.3g / Kg body weight.

[0044] In the IVIg+Lachnospiraceae group, Lachnospiraceae were orally administered once within 30 minutes before whole-body irradiation, and IVIg was injected intravenously once within 5 minutes after irradiation, followed by IVIg twice a week for two weeks, and Lachnospiraceae were orally administered every two days. Each Lachnospiraceae dose is 1*10 7 Each IVIg dose is ...

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Abstract

The invention discloses a combined medicine of hispiraceae bacteria and human immune globulin for injection, and belongs to the field of biological pharmacy. Researches show that the human immune globulin for injection has the effect of treating the radioactive injury, and the treatment effect can be further enhanced by combining the hispiraceae bacteria and the human immune globulin for injection. Therefore, the combined medicine disclosed by the invention is of great significance to patients receiving radiotherapy and people accidentally receiving excessive irradiation.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals. Background technique [0002] Cancer is the second leading cause of death in human beings. Radiation therapy ("radiotherapy") is a widely used method of cancer treatment. The contribution rate to cancer treatment is as high as 18%, which is second only to surgery and significantly higher than chemotherapy and biological therapy. . However, it is unavoidable that radiation therapy is accompanied by varying degrees of acute and chronic organ damage represented by inflammation and fibrosis. Specifically, radiation therapy for head and neck tumors often leads to oral mucositis; radiation therapy for chest tumors often leads to chronic pneumonia; radiation therapy for pelvic and abdominal tumors often leads to diarrhea, chronic enteritis, and intestinal obstruction. However, hematopoietic injury represented by leukopenia and myeloid deviation, and gastrointestinal injury represented by enteritis an...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P5/00A61P7/00A61P35/00A61K35/74
CPCA61K39/395A61K35/74A61P35/00A61P7/00A61P5/00A61K2300/00A61P39/00A61K2039/505A61K2039/545A61K35/16A61K35/741
Inventor 崔明王宗奎李长清徐俊程露
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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