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Application of composition to preparation of drugs

A technology for preparing medicines and compositions, which is applied in the field of use of compositions in the preparation of medicines, can solve problems to be strengthened, etc., and achieve the effects of promoting efficiency and wide sources.

Inactive Publication Date: 2017-03-08
SOUTH CHINA INSTITUDE OF BIOMEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current research on bioengineered tissue repairing cartilage damage still needs to be strengthened

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The composition for cartilage damage repair is prepared according to the following steps, and the cartilage damage patients are transplanted and repaired:

[0028] 1. Isolation and culture of UCMSC

[0029] The fresh umbilical cords were sent to the GMP production workshop, and UCMSCs were obtained by separation. The UCMSCs were cultured and expanded; some cells were taken out to induce chondrocytes, and a certain number of chondrocytes were obtained and then expanded for transplantation.

[0030] 2. Preparation before transplantation

[0031] Digest the UCMSCs obtained above and the chondrocytes induced to differentiate with 0.25% trypsin, wash with saline, then mix the UCMSCs and chondrocytes at a ratio of 1:1 to 4:1 and resuspend them in hyaluronic acid solution, so as to obtain a cell suspension, wherein the content of hyaluronic acid in the cell suspension is 5-30 mg / ml. The cell suspension is mixed with the temperature-sensitive polylactic acid hydrogel MPEG-PL...

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PUM

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Abstract

The invention discloses application of a composition to preparation of drugs. The drugs are used for repairing cartilage injury. The composition comprises cell suspension and temperature-sensitive hydrogel, wherein the cell suspension is formed by mixing of mesenchymal stem cells and cartilage cells and resuspending the mixture on a hyaluronic acid solution. The composition for repairing the cartilage injury is safe, reliable, convenient to obtain, high in efficiency for differentiating towards the cartilage cells and capable of providing necessary cells for tissue repair of cartilage injury parts, and the temperature-sensitive hydrogel can function as a good exogenous cell carrier and enables the cells in the composition to fill the cartilage injury parts without migrating towards other positions, so that rapid effective repair and healing of the cartilage injury parts can be promoted effectively.

Description

technical field [0001] The invention relates to the use of the composition in the preparation of medicines. Background technique [0002] Articular cartilage (AC) damage is a major risk factor for osteoarthritis (OA). OA is irreversible. When the disease develops to an advanced stage, joint replacement is required to relieve pain and restore function. Since the repair capacity of articular cartilage is limited, early intervention is necessary to prevent progression to OA. Current treatment modalities aim to repair articular cartilage through primary therapy, stimulation of adjacent tissues, and grafting. Reasonable restorative treatment can achieve ideal results in the short to medium term, but after a long period of time, it is easy to relapse. In recent years, tissue engineering technology based on bioengineered tissue at the cell level has been extensively studied. This bioengineered tissue can reproduce the characteristics of hyaline cartilage and integrate with the or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/32A61K35/28A61K9/10A61K47/36A61K9/06A61K47/34A61L27/38A61L27/52
CPCA61K35/32A61K9/06A61K9/10A61K35/28A61K47/34A61K47/36A61L27/3817A61L27/3834A61L27/3852A61L27/52A61L2400/06A61L2430/06A61K2300/00
Inventor 裴雪涛姚海雷南雪岳文游子娟
Owner SOUTH CHINA INSTITUDE OF BIOMEDICINE
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