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Anti-drug resistance antidiarrheal microbial preparation and preparation method thereof

A microbial preparation, drug resistance technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Effect

Inactive Publication Date: 2017-03-08
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, naked phages are easily inactivated by body resistance factors such as gastric juice, and phages protected by host bacteria must first destroy the bacteria before further destroying the phages because the phages have already invaded the host bacteria.

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0056] Correspondingly, the present invention also provides a preparation method of an anti-drug resistance antidiarrheal microbial preparation, comprising:

[0057] Add 15-25% glycerol saline to the purified phage liquid obtained by filtration, shake well; then add montmorillonite nano powder, the ratio of montmorillonite nano powder to phage liquid is 0.5-1:1-2, stir well into a paste, and the stirring time is 1-2 hours, so that the montmorillonite can fully absorb the phage; then the mixture is dried below 35°C, and the moisture content of the dried mixture is lower than 12%; finally, the mixture is ground into powder to obtain Montmorillonite pretreatment;

[0058] The pretreated montmorillonite, lactobacillus acidophilus powder, streptococcus faecalis powder, licorice powder and pomegranate peel powder are mixed, stirred evenly, and the finished product is obtained.

[0059] Preferably, the preparation method comprises:

[0060] Add 15-25% glycerol saline to the purifie...

Embodiment 1

[0065] (1) Formula: 2 parts of montmorillonite pretreatment, 0.5 part of Lactobacillus acidophilus powder, 0.1 part of streptococcus faecalis powder, 1 part of licorice powder, 0.1 part of pomegranate peel powder, wherein the montmorillonite pretreatment includes montmorillonite Desalting nano powder and phage liquid, montmorillonite nano powder: phage liquid = 0.5:1.

[0066] (2) Preparation method:

[0067] Add 15% glycerol saline to the purified phage liquid obtained by filtration, and shake well; then add montmorillonite nanopowder, and stir evenly to form a paste. The stirring time is 1 hour, so that the montmorillonite can fully absorb the phage; Dry below 35°C, and the moisture content of the dried mixture is less than 12%; finally, grind the mixture into powder to obtain montmorillonite pretreatment;

[0068] The pretreated montmorillonite, lactobacillus acidophilus powder, streptococcus faecalis powder, licorice powder and pomegranate peel powder are mixed, stirred e...

Embodiment 2

[0070] (1) Formula: 3 parts of montmorillonite pretreatment, 2 parts of Lactobacillus acidophilus powder, 1 part of Streptococcus faecalis powder, 2 parts of licorice powder, 1 part of pomegranate peel powder, wherein the montmorillonite pretreatment includes montmorillonite Desalting nano powder and phage liquid, montmorillonite nano powder: phage liquid = 1:1.

[0071] (2) Preparation method:

[0072] Add 20% glycerol saline to the purified phage liquid obtained by filtration, and shake well; then add montmorillonite nanopowder, and stir evenly to form a paste. The stirring time is 1.5 hours, so that the montmorillonite can fully absorb the phage; Drying below 35°C, the moisture content of the dried mixture is less than 10%; finally, the mixture is ground into powder to obtain montmorillonite pretreatment;

[0073] The pretreated montmorillonite, lactobacillus acidophilus powder, streptococcus faecalis powder, licorice powder and pomegranate peel powder are mixed, stirred e...

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Abstract

The invention discloses an anti-drug resistance antidiarrheal microbial preparation which comprises the following components: 4-10 parts of montmorillonite pretreatment substance, 0.1-3 parts of bacteriophage liquid, 0.5-5 parts of lactobacillus acidophilus powder and 0.1-3 parts of streptococcus faecalis powder, wherein the montmorillonite pretreatment substance is prepared by the following steps: adding water into 60-80% of montmorillonite nano powder, 10-30% of liquorice and 5-15% of pericarpium granati and mixing; boiling for 0.5-2 hours; drying the mixture; and finally, grinding the mixture into powder. Correspondingly, the invention also discloses a method for preparing the microbial preparation. In the invention, the bacteriophage in the microbial preparation easily breaks through the immune barrier and cooperates with the probiotics and herbal medicine components in the preparation to prevent and treat the infected intestinal diseases caused by corresponding prokaryotic and eukaryotic cell type microorganisms in the body and to prevent and treat allergic diarrhea; and moreover, the generation of animal-source drug-resistant bacteria can be delayed.

Description

technical field [0001] The invention relates to the field of biological preparations, in particular to a drug-resistant antidiarrheal microbial preparation and a preparation method thereof. Background technique [0002] At present, with the increasingly severe microbial resistance and the rapid increase of drug-resistant bacteria and their drug-resistant spectrum, multi-drug-resistant bacteria and super-drug-resistant bacteria have become a thorny problem in modern medicine. Finding new effective and non-toxic side effects Antibacterial preparations have become an urgent problem to be solved in the treatment of microbial infectious diseases. [0003] Phages are viruses that infect microorganisms such as bacteria, fungi, actinomycetes, and spirochetes, and are highly specific to host bacteria. According to the status and results of their infection of the host bacteria, phages are divided into two types, one of which can replicate and proliferate in the host bacteria cells, p...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P31/04A61K33/06A61K35/747A61K35/744A61K31/4375
CPCA61K36/484A61K31/4375A61K33/06A61K35/744A61K35/747A61K36/185A61K2300/00
Inventor 万学勤李宏鸣
Owner FOSHAN UNIVERSITY
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