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A wrinkle neural electrode array system and a preparation method therefor

An electrode array and electrode system technology are applied in the field of folded neural electrode array system and its preparation, which can solve the problems of difficulty in simultaneously improving the neural electrode spatial resolution, neural electrode signal-to-noise ratio, electrode failure, etc. The effect of excellent biocompatibility, high spatial resolution and sensitivity

Active Publication Date: 2017-03-22
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to solve the problem that if the size of the nerve electrode is reduced in the prior art, the signal-to-noise ratio will be reduced and the electrode will easily fail, and it is difficult to simultaneously improve the spatial resolution of the nerve electrode and ensure that the nerve electrode has a higher signal-to-noise ratio than the problem

Method used

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  • A wrinkle neural electrode array system and a preparation method therefor
  • A wrinkle neural electrode array system and a preparation method therefor
  • A wrinkle neural electrode array system and a preparation method therefor

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Embodiment 1

[0046] Such as figure 1 , figure 2 and image 3 As shown, the wrinkled nerve electrode array system provided by Embodiment 1 of the present invention includes a package body 1, an external interface 2, and a wrinkled electrode array 3. The package body 1 includes an elastic substrate 11 and an insulator 12, and the electrode array 3 and The upper surface of the elastic substrate 11 is laminated, the electrode array 3 and the external transfer interface 2 are connected through the outer lead 4, and the insulator 12 is pasted on the elastic substrate 11 and the external transfer interface 2 to package the electrode array 3 and the outer lead 4 In the package 1 , the insulator 12 is provided with a notch 120 , the electrode array 3 includes one or more nerve electrodes 31 , and the notch 120 exposes the effective detection parts of the nerve electrodes 31 .

[0047] The folded nerve electrode array system of the present invention covers the inner leads, bonding sites, outer lead...

Embodiment 2

[0062] The preparation method of the folded nerve electrode system provided by the second embodiment of the present invention includes the following steps:

[0063] Step 1, preparing an elastic substrate;

[0064] The elastic substrate can choose SMOOTH-ON Ecoflex series silicone, polydimethylsiloxane or 3M VHB series adhesive tape. In this example, SMOOTH-ON Ecoflex series silicone Ecoflex 0030 is used to make the elastic substrate. Take the same amount of Ecoflex 0030A glue and Ecoflex 0030B glue and mix evenly. After vacuum defoaming, pour it into a pre-prepared container and let it stand for curing. It is necessary to ensure that the bottom of the container is clean and flat. By adjusting the amount of glue taken and the volume of the container, the thickness of the cured elastic substrate can be conveniently regulated.

[0065] Step 2, after depositing SiO 2 The electrode array is prepared on the Si substrate;

[0066] While waiting for the elastic substrate to solidi...

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Abstract

The invention relates to the technical field of micromachining and in particular provides a wrinkle neural electrode array system and a preparation method therefor. The wrinkle neural electrode array system comprises a package body, an external switch-over connector and an electrode array subjected to wrinkle treatment. The package body comprises an elastic substrate and an insulator; the electrode array is attached to the upper surface of the elastic substrate; the electrode array is connected with the external switch-over connector via an external lead; the insulator is attached to the elastic substrate and the external switch-over connector to package the electrode array and the external lead in the package body; the insulator is provided with a notch; the electrode array comprises one or more neural electrodes; the notch can expose effective detection portions of the neural electrodes. Through wrinkle treatment, the planar projection area of the neural electrodes is reduced, so that on the condition that the signal to noise ratio of the neural electrodes is not harmed, the electrode space resolution is increased and the space resolution and sensitivity are high; the system is used for monitoring and recording neural electric signals, matches the mechanical properties of biological tissue and has better biological compatibility.

Description

technical field [0001] The invention relates to the technical field of micromachining, in particular to a folded nerve electrode array system and a preparation method thereof. Background technique [0002] The brain is the most complex system in nature, mainly composed of hundreds of different types and a total of 10 11 Nerve cells (or "neurons"). Each neuron has an axon for output signals and a dendrite for receiving input signals in shape. The connection point formed by the axon of one neuron and the dendrite of another neuron is called a "synapse"; a synapse is A bridge for the transmission of information between neurons; each neuron forms synaptic connections with, on average, thousands of other neurons, forming neural circuits. Neuroelectric signals related to brain function are transmitted and processed through neural circuits, and elucidating the working mechanism of neural circuits is the core goal of brain science. Electrophysiological detection technology is the...

Claims

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Application Information

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IPC IPC(8): A61B5/04
CPCA61B2503/40A61B2562/0209A61B2562/125A61B5/24
Inventor 方英杨龙
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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