Plant essence itching-relieving mosquito-repellent liquid and manufacturing method thereof
A technology of plant essence and production method, applied in skin care preparations, drug combinations, pharmaceutical formulas, etc., can solve the problems of short repellent time and unsafe use of non-natural components
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Embodiment 1
[0019] The production method of plant essence itching and mosquito repellent is made by the following steps:
[0020] Get 7 parts by weight of clove oil, 8 parts by weight of lemon eucalyptus oil and add in the ethanolic aqueous solution of 40 weight parts to obtain the first solution, and described ethanolic water solution is 70% ethanolic water solution (v / v); Described lemon eucalyptus oil, clove oil can be Obtained by using the existing extraction technology, optionally, the lemon eucalyptus oil is the volatile oil obtained by distilling lemon eucalyptus leaves by steam distillation, and the clove oil is the volatile oil obtained by steam distillation distillation of clove leaves. Before distillation The lemon eucalyptus leaves and clove leaves are crushed and preferably passed through a five-mesh sieve.
[0021] Take 10 parts by weight of Cnidium, 10 parts by weight of Kochia, 15 parts by weight of Artemisia argyi, the water content of described Cnidium, Kochia kohlrabi i...
Embodiment 2
[0024] A plant essence antipruritic mosquito repellent liquid is prepared by any one of the aforementioned methods for making plant essence antipruritic mosquito repellent liquid.
Embodiment 3
[0026] Acute oral toxicity test in rats.
[0027] Test sample: 6g of plant essence antipruritic mosquito repellent liquid in Example 1 was added to 12mL of water and mixed well, and used as a test sample.
[0028] Experimental animals: Wistar rats with a body weight of 160-200 g, 3 males and 3 males, and 6 rats in total were selected that had been adapted for more than 2 days in the laboratory and had no abnormal health status.
[0029] Test method: Animals were fasted overnight, and 2ml per animal was orally administered orally, and the symptoms after intragastric administration were observed and recorded, and the median lethal dose (LD50) was calculated for two weeks of continuous observation.
[0030] Experimental results: no obvious poisoning symptoms, no death. The median lethal dose was not measured, or the acute oral median lethal dose for males and females was greater than 5000 mg / kg.
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