Euryale ferox shell extract and preparation method and application thereof

A technology of extract and Gorgon shell, applied in the field of traditional Chinese medicine, can solve the problem of unclear lipid-lowering active ingredients and the like

Inactive Publication Date: 2017-03-22
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the lipid-lowering active ingredients in the gorgon shell are not clear, and more extensive and in-depth research is needed

Method used

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  • Euryale ferox shell extract and preparation method and application thereof
  • Euryale ferox shell extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take 1 kg of dried Gorgon husk, crush it, and extract it twice with 10 L of ethanol solution with a mass percentage concentration of 80% at 70°C for 2 hours each time, combine the extracts, filter, and concentrate under reduced pressure until there is precipitation, 3000 Centrifuge at rpm for 15 minutes, and take the supernatant for later use;

[0013] Weigh Amberlite TM Add 800g of XAD16 macroporous adsorption resin, add appropriate amount of distilled water, and place it overnight at room temperature to fully swell the resin, pack the column in a wet method, wash the column with 95% ethanol, and finally rinse the column with distilled water until the effluent has no ethanol smell. overnight.

[0014] Slowly flow the above supernatant through the above-mentioned treated and balanced macroporous resin column, first rinse with deionized water, and then elute with different concentrations of ethanol gradients, collect water and 50% ethanol elution sites respectively, an...

Embodiment 2

[0015] Example 2: Study on the Slimming Activity of Gorgon Shell Extract

[0016] Establishment of obese mouse model: normal-grade Kunming mice, male, weighing (20±2) g, purchased from Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing City, 5 mice were randomly selected as the blank group and fed with normal diet, and the rest mice were fed with normal diet. Rats were fed with high-sugar and high-fat feed (formula: pellet standard feed 66.7%, sucrose 15%, lard 12%, egg yolk 5%, cholesterol 1%, pig bile salt 0.3%) for 4 weeks after adapting to the environment for 3 days. The weight of mice in the blank group was 20% and the model was considered successful.

[0017] Experimental method: After successful modeling, record the body weight, and divide the mice into model group and Gorgon fruit shell extract at random, wherein the Gorgon fruit shell extract group was given the water part of Gorgon fruit shell extract prepared according to Example 1 (100mg / kg ), Gorgon s...

Embodiment 3

[0022] Example 3: Lipid-lowering activity of Gorgon husk extract

[0023] According to the modeling and experimental methods described in Example 2, after 4 weeks of administration, after fasting for 24 hours, the eyeballs were removed to take blood, and the triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured in the serum. .

[0024] Experimental results:

[0025] Table 2 Effect of Gorgon husk extract on TG, TC, HDL, LDL of obese mice (mean±SD, n=10)

[0026]

[0027] As shown in Table 2, compared with the blank group, the contents of TG, TC, HDL and LDL in the serum of obese mice were significantly increased ( P P <0.05). The results suggest that Gorgon husk extract has the effect of reducing blood lipids in obese mice.

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Abstract

The invention discloses euryale ferox shell extract and a preparation method and application thereof. The euryale ferox shell extract uses euryale ferox fruit shells as a raw material and is prepared through ethanol extraction and a macroporous resin purification method. The invention particularly discloses the preparation method of the euryale ferox shell extract and the application of the euryale ferox shell extract used as weight-losing and lipid-lowering medicine. Based on scientific experiments, the applicant discovers that the prepared euryale ferox shell extract can remarkably improve lipid metabolism of obese mice induced by high-glucose and high-lipid fodder and lose weight and can be used as weight-losing and hyperlipoidemia-treating medicine or a health care product to be further studied and developed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation method of Gorgon fruit husk extract and its application in medicine or health care product for treating obesity and hyperlipidemia. Background technique [0002] Overweight and obesity are global epidemics and serious public health problems. my country's obese patients are also increasing rapidly. The current adult overweight rate is 32.1%, and the obesity rate is as high as 9.9%. Obesity is closely related to many diseases, such as hypertension, hyperlipidemia, type 2 diabetes, stroke, coronary heart disease and so on. Therefore, the development of effective weight-loss and lipid-lowering drugs has become a research hotspot. [0003] Gorgon ( Euryale ferox Salisb.) is an aquatic plant of the genus Gorgon in the family Nymphaeaceae, and Gorgon is its mature fruit. Gorgon seed kernels, also known as chicken head rice, have high medicinal a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61P3/04A61P3/06A23L33/00A61K131/00
CPCA23V2002/00A61K36/62A61K2236/333A61K2236/51A61K2236/53A61K2236/55A23V2200/332A23V2200/3262
Inventor 简暾昱陈剑吕寒马丽任冰如童贝吴月娴
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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