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Yao medicine composition for external use, preparation method thereof and drug containing same

A composition and technology of Yao medicine, applied in the field of medicine, can solve the problems of not improving the quality of life of patients, long treatment time, single western medicine treatment, etc., and achieve the effect of being suitable for large-scale industrial production, simple and easy-to-obtain equipment, and easy reaction conditions

Inactive Publication Date: 2017-03-29
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine has no particularly effective drugs to treat this disease. Most of the drugs focus on pain relief, anti-inflammation, and resistance to viruses. There are defects such as high medical cost and certain adverse reactions in the treatment of this disease
[0004] Both Chinese and Western medicine have their own advantages in the treatment of herpes zoster. Western medicine treatment is relatively single, the virus replicates and mutates more, the pertinence of antiviral drugs is poor, and commonly used antiviral drugs have symptoms such as allergic reactions, arthralgia, nausea, Vomiting and other side effects, large doses may also cause renal damage
In the treatment of herpes zoster, traditional Chinese medicine has rich methods and means, including internal treatment, external treatment, acupuncture and physical therapy, etc. For example, in the acute attack period, the main method is to clear away heat and dampness, activate blood circulation, remove blood stasis and relieve pain, and cooperate with clearing the liver and purging fire or strengthening the spleen and stomach. Spleen dehumidification; for chronically ill patients with qi and blood deficiency, it is given to nourish qi and blood, strengthen the body and strengthen the foundation. Although the overall curative effect is accurate and there is no adverse reaction, the effect on residual neuralgia is not good, and the treatment time is relatively long
[0005] Although the combination of Chinese and Western medicine in the treatment of herpes zoster and residual neuralgia can improve the clinical efficacy compared with the treatment of Western medicine alone, adverse reactions such as nausea, diarrhea, and dizziness will still occur during the course of treatment, and the quality of life of patients has not been improved.

Method used

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  • Yao medicine composition for external use, preparation method thereof and drug containing same
  • Yao medicine composition for external use, preparation method thereof and drug containing same
  • Yao medicine composition for external use, preparation method thereof and drug containing same

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preparation example Construction

[0037] The present invention also provides the preparation method of the external-use Yao medicine composition described in the above technical scheme, comprising the following steps:

[0038] (1) drying after the solid raw material described in the technical scheme is pulverized;

[0039] (2) mixing the dried solid raw material with an aqueous ethanol solution with a volume concentration of 70-80%, and sealing for 28-35 d for the first time;

[0040] (3) mixing the mixture obtained by the first sealing with an aqueous ethanol solution with a volume concentration of 18-25%, resealing for 6-10 d, and resealing again to obtain a medicinal composition for external use.

[0041] In the present invention, preferably, the solid raw materials of the external-use Yao medicine composition are washed and dried before the pulverization. In the present invention, the drying method is preferably sun drying.

[0042] The present invention has no special limitation on the pulverizing metho...

Embodiment 1

[0054] Take the following solid raw materials in parts by weight: 0.5 part of borneol, 0.5 part of dried blood, 1.5 part of large diamond, 1.5 part of small diamond, 1.5 part of square diamond and 1.5 part of rhizoma rhizoma, washed respectively, dried in the sun, pulverized to 20 meshes and carried out Mix and dry at 90°C for 3.5h. The dried solid raw material was mixed with 0.27 parts by weight of a 70% ethanol aqueous solution, and sealed for 28 days for the first time; the mixture obtained by the first sealing was mixed with 0.06 parts by weight of an 18% ethanol aqueous solution, and sealed again for 6 days, After the resealing is completed, the external-use Yao medicine composition is obtained.

Embodiment 2

[0056] Get the following solid raw materials in parts by weight: 2 parts of borneol, 2 parts of dried blood, 4 parts of large diamonds, 4 parts of small diamonds, 4 parts of square diamonds and 4 parts of mountain tigers, washed respectively, dried in the sun, pulverized to 80 meshes and carried out Mix and dry at 110°C for 1.5h. The dried solid raw material was mixed with 0.41 parts by weight of an 80% ethanol aqueous solution with a volume concentration of 80%, and sealed for 28 days for the first time; the mixture obtained from the first sealing was mixed with 0.09 parts by weight of a 25% ethanol aqueous solution with a volume concentration of 25%, and sealed again for 6 days. After the resealing is completed, the medicinal liquid is filtered to obtain the medicinal liquid, which is the medicinal composition for external use.

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Abstract

The invention provides a Yao medicine composition for external use. The Yao medicine composition comprises, by weight, 1-4 parts of borneol, 1-4 parts of daemonorops draco, 1.5-5 parts of kadsura coccinea, 1.5-5 parts of kadsura longipedunculata, 1.5-5 parts of cissus hastata and 1.5-5 parts of toddalia asiatica. Proven by clinical trials, when the Yao medicine composition for external use is applied jointly with traditional Chinese medicines for treating herpes zoster and left neuralgia, the pain easement effective rate is 95.24%, 11.9+ -1.0d can make the pain disappear. The swelling easement effective rate is 96.83%. The Yao medicine composition for external use has the advantages of being low in treatment cost, having no obvious negative effect, and being capable of enhancing the life quality of a patient.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicinal composition for external use and a preparation method and application thereof. Background technique [0002] Herpes zoster is an acute herpetic skin disease, mainly caused by chickenpox and herpes zoster virus. About 10% of the patients with herpes zoster have postherpetic neuralgia, which is mainly clinically manifested as allodynia, unbearable itching, persistent burning pain, spontaneous knife-like pain, etc. , fatigue, drinking and other factors aggravate, have a serious impact on the patient's physical and mental. [0003] Modern medicine believes that neuralgia remnant from herpes zoster is a skin infection caused by the activation of primary infection with chickenpox and herpes zoster virus. Inflammation and necrosis, forming a vicious cycle of pain. At present, Western medicine has no particularly effective drugs to treat this kind of disease. Most of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K36/896A61P31/22A61P25/00A61K31/045
CPCA61K31/045A61K9/0014A61K36/57A61K36/758A61K36/79A61K36/87A61K36/889A61K36/896A61K2236/17A61K2236/333A61K2300/00
Inventor 戴建业张曼
Owner GUANGXI UNIV OF CHINESE MEDICINE