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Drug composition consisting of Zifaxaban and ginsenoside Rb3, and application

A technology of ginsenoside and composition, which is applied in the field of medicine, can solve the problems of increased bleeding volume, bleeding side effects, and prolonged bleeding time, and achieve the effects of small bleeding side effects, reduced dosage, and good antithrombotic activity

Inactive Publication Date: 2017-04-19
孙双勇 +6
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, similar to other FXa inhibitors, while Foxaban exerts antithrombotic effects, it also has certain bleeding side effects, which are specifically manifested as prolonged bleeding time and increased bleeding volume.

Method used

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  • Drug composition consisting of Zifaxaban and ginsenoside Rb3, and application
  • Drug composition consisting of Zifaxaban and ginsenoside Rb3, and application

Examples

Experimental program
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Embodiment

[0010] The present invention will be further described below in conjunction with embodiment. The examples are illustrative only and are in no way meant to limit the scope of the invention in any way.

[0011] Antithrombotic Effect of Zhifei Shaban-Ginsenoside Rb3 Composition on Inferior Vena Cava Thrombosis in Rats

[0012] 1. Materials:

[0013] 1.1 Drugs and reagents:

[0014] Zhifei Shaban Intestine: Provided by the Drug Innovation Research Center of Tianjin Institute of Pharmaceutical Research, batch number H-121225. Dissolve in 1% CMC-Na before use;

[0015] Ginsenoside Rb3: provided by the Department of Pharmacognosy, School of Pharmacy, Jilin University, batch number: 140526. It can be dissolved in 1% CMC-Na immediately before use.

[0016] Total protein detection kit, product of Ningbo Kangmei Biotechnology Co., Ltd., batch number: 110991. Follow the instructions.

[0017] 1.2 Animals

[0018] Wistar rats were provided by Beijing Weitong Lihua Experimental Anim...

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Abstract

The invention provides a drug composition consisting of Zifaxaban and ginsenoside Rb3 in view of limitation of an antithrombotic drug, namely, Zifaxaban. The antithrombotic activity of the composition is remarkably higher than that of the Zifaxaban during single use; the clinical usage dosage of the Zifaxaban can be remarkably reduced; the hemorrhage side effects of the Zifaxaban can be reduced; and the drug composition can be used for preventing and treating cardiovascular and cerebrovascular diseases such as thromboembolism and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for preventing and treating thrombosis composed of phenoxaban and ginsenoside Rb3, and its application in the prevention and treatment of thromboembolic diseases. Background technique [0002] Thrombotic disease is a common cardiovascular and cerebrovascular disease. It is a variety of diseases caused by the stenosis and occlusion of the blood vessel cavity caused by thrombus, which causes ischemia and infarction of major organs and causes dysfunction. It often manifests as myocardial infarction, ischemia, etc. cerebral infarction and venous thromboembolism. It can affect various organs and systems of the whole body, and its morbidity, disability and mortality are all high. Every year, about 3‰ people suffer from different forms of thrombotic disease, which seriously threatens human health. [0003] Zhifei Shaban is a new antithrombotic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P7/02A61K31/4439
Inventor 孙双勇王维亭郝春华席文恭徐向伟赵专友汤立达
Owner 孙双勇
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