Heated Ionization Apparatus Based on Desolvation of Electrospray Ionization Source
A technology of electrospray ionization source and heating device, which is applied in ion source/gun, parts and circuits of particle separator tubes, etc., can solve the problems of low ionization efficiency, uneven heating of ions, low ionization efficiency, etc. To achieve the effect of improving desolvation efficiency, improving resolution, and improving ionization efficiency
Active Publication Date: 2019-06-21
SHANGHAI YUDA IND
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Problems solved by technology
However, this method has certain disadvantages: a large amount of gas needs to be consumed during use, which increases the cost of use; the drying gas must be kept at a certain temperature, otherwise the solvent cannot be completely removed, which will lead to low ionization efficiency, and the countercurrent gas is at a certain level. will disperse the droplets
At present, some studies have used an alcohol lamp placed at the mouth of a metal capillary to heat ions to increase their desolvation degree, but this heating method tends to cause uneven heating of ions, resulting in low ionization efficiency
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[0021] The preferred embodiments of the present invention are given below in conjunction with the accompanying drawings to describe the technical solution of the present invention in detail.
[0022] Such as Figure 1 to Figure 3 As shown, the heating ionization device based on the desolvation of the electrospray ionization source in the present invention includes a metal capillary and a heating device. The number of the heating device is at least one, and the plurality of heating devices are independent of each other. The heating device is located between the spray needle and the metal capillary. In between, the heating device is provided with at least one adiabatic adjustment device, the heating device adjusts the position of the relative spray needle and the metal capillary through the adiabatic adjustment device, and the adiabatic adjustment device is also used to adjust the distance between the two heating devices.
[0023] The heating device is a ring structure or a mesh...
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The invention discloses a heating ionization device based on the desolvation of an electro-spray ionization source. The device comprises a metal capillary and at least one heating device. Multiple heating devices are mutually independent and are positioned between an atomizing needle and the metal capillary. The heating device is provided with at least one heat-insulating adjustment device. The position of the heating device, relative to the atomizing needle and the metal capillary, is adjusted by the heat-insulating adjustment device. The distance between two heating devices is also adjusted by the heat-insulating adjustment device. According to the technical scheme of the invention, the desolvation efficiency and the ionization efficiency of droplets are improved through the direct and uniform heating process of ions. Therefore, the effect of improving the high-flow-rate ESI resolution is achieved.
Description
technical field [0001] The invention relates to an ionization device, in particular to a heating ionization device based on the desolvation of an electrospray ionization source. Background technique [0002] The ion source is the core component of the mass spectrometer. It ionizes the injected neutral substance into ions, so that the mass analyzer can perform mass analysis, so it plays a very important role in the field of mass spectrometry technology. There are many types of ion sources, including fast atom bombardment ionization (FAB), electron impact ionization (EI), chemical ionization (CI), matrix-assisted excitation desorption ionization (MALDI), electrospray ionization (ESI) And atmospheric pressure chemical ionization source (APCI), etc. Among them, as a relatively new ionization technology, electrospray ionization (ESI) has attracted much attention because of its own unique advantages and broad development prospects. [0003] Electrospray ionization source (Electr...
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IPC IPC(8): H01J49/16H01J49/26
CPCH01J49/165H01J49/26
Inventor 肖育姚如娇陈延龙丁正知汪新舜
Owner SHANGHAI YUDA IND