Luseogliflozin pharmaceutical composition, and preparation method thereof
A composition and medicine technology, applied in the field of lupagliflozin pharmaceutical composition and preparation thereof, can solve the problems of low melting point of medicine, large specific surface area of medicine, low density of medicine and the like
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Embodiment 1
[0019] Prescription Composition of Luxagliflozin Tablets
[0020] Luxagliflozin 100g
[0021] Povidone 50g
[0022] Lactose 50g
[0024] Preparation:
[0025] Step (1): Take 100g of Luxagliflozin, add 1500g of ethanol, stir to dissolve or disperse evenly, and use it as solution A for later use.
[0026] Step (2): Take 50g of povidone (K30) and 50g of lactose, add 500g of purified water, stir to dissolve, and make solution B.
[0027] Step (3): Add solution A to solution B, stir to make it evenly dispersed, and use it as solution C.
[0028] Step (4): Solution C is spray-dried in a spray dryer, and the temperature of the spray-drying is controlled to be 100°C; the spray-dried material is collected, passed through a 60-mesh sieve, added with an appropriate amount of lubricant, and compressed into tablets to obtain Delupagliflozin Tablets .
Embodiment 2
[0030] Prescription Composition of Luxagliflozin Tablets
[0031] Luxagliflozin 100g
[0032] Low-substituted hydroxypropyl cellulose 50g
[0033] Mannitol 150g
[0035] Preparation
[0036] Step (1): Take 100g of Luxagliflozin, add 700g of acetone, stir to dissolve or disperse evenly, and use it as solution A for later use.
[0037] Step (2): Take 50 g of low-substituted hydroxypropyl cellulose and 150 g of mannitol, add 1000 g of purified water, stir, and dissolve them as solution B.
[0038] Step (3): Add solution A to solution B, stir to make it evenly dispersed, and use it as solution C.
[0039] Step (4): Solution C is spray-dried in a spray dryer, and the temperature of the spray-drying is controlled to be 115°C; the spray-dried material is collected, passed through a 60-mesh sieve, added with an appropriate amount of lubricant, and compressed into tablets to obtain Delupagliflozin Tablets .
Embodiment 3
[0041] Prescription Composition of Luxagliflozin Tablets
[0042] Luxagliflozin 100g
[0043] Low-substituted hydroxypropyl cellulose 50g
[0044] Xylitol 100g
[0046] Preparation
[0047] Step (1): Take 100g of Luxagliflozin, add 1500g of ethanol-isopropanol solution (2:8, w / w), stir to dissolve or disperse evenly, and use it as solution A for later use.
[0048] Step (2): Take 50 g of low-substituted hydroxypropyl cellulose and 100 g of xylitol, add 800 g of aqueous solution, stir to dissolve, and make solution B.
[0049] Step (3): Add solution A to solution B, stir to make it evenly dispersed, and use it as solution C.
[0050] Step (4): Solution C is spray-dried in a spray dryer, and the temperature of the spray-drying is controlled to be 105°C; the spray-dried material is collected, passed through a 60-mesh sieve, added with an appropriate amount of lubricant, and compressed into tablets to obtain Delupagliflozin Tablets .
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