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Chronic low-perfusion PD (Parkinson's disease) mouse model as well as preparation method and device thereof

A Parkinson's disease and mouse model technology, applied in the field of biomedicine, can solve problems such as unstable behavioral symptoms, achieve typical performance, improve success rate, and easy operation

Inactive Publication Date: 2017-05-10
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above methods can induce typical behavioral symptoms of Parkinson's disease, there are obvious disadvantages: behavioral symptoms are unstable; non-motor symptoms are rarely shown

Method used

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  • Chronic low-perfusion PD (Parkinson's disease) mouse model as well as preparation method and device thereof
  • Chronic low-perfusion PD (Parkinson's disease) mouse model as well as preparation method and device thereof
  • Chronic low-perfusion PD (Parkinson's disease) mouse model as well as preparation method and device thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of embodiment 1 animal model of the present invention

[0054] 1. Materials

[0055] 1. Experimental animals

[0056] The experimental animals were 82 male C57BL / 6 mice, 5-6 weeks old, weighing 18-22 g, all purchased from the Experimental Animal Center of Sun Yat-sen University.

[0057] 2. Micro spring coil

[0058] Purchased from Sawane Spring Co. (Shizuoka, Japan), the main components are as follows: carbon 0.8-0.85% (w / w), silicon 0.12-0.32% (w / w), manganese 0.3-0.6% (w / w), Phosphorus 0.025% (w / w), sulfur 0.025% (w / w) and copper 0.2% (w / w), and the surface of the coil is gold-plated. The miniature spring coil is composed of 5 coils with a pitch of 0.5mm, the thickness of the coil material is 0.08mm, the total length is 2.5mm, and the inner diameter is 0.18mm.

[0059] 3. Glass hook

[0060] The glass hook includes a hook point and a hook handle, one end of the hook point is connected with the hook handle, the other end of the hook point is spher...

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Abstract

The invention discloses a chronic low-perfusion PD (Parkinson's disease) mouse model as well as a preparation method and device thereof. Probenecid and MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) are administrated jointly to a mouse with bilateral common carotid artery coarctation, and the chronic low-perfusion PD mouse model is obtained. The provided method is simple and safe to operate; the success rate is high; the cognitive disorder simulation performance of the obtained mouse model is typical.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a mouse model of chronic hypoperfusion Parkinson's disease and a preparation method and device thereof. Background technique [0002] Parkinson's disease (PD) is a common degenerative disease of the nervous system in middle-aged and elderly people. With the continuous acceleration of the aging process in our country, its incidence rate is increasing year by year. According to the survey and research results on the prevalence of Parkinson's disease, there are more than 2 million patients with Parkinson's disease in my country at present, and the prevalence rate is about 2% among the elderly population over 65 years old. According to incomplete statistics, it is estimated that by 2030, the number of patients with Parkinson's disease in my country will reach 5 million, which shows that the social burden brought by Parkinson's disease is particularly worrying. Cogni...

Claims

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Application Information

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IPC IPC(8): A61K31/4418A61K31/195A61K49/00A01K67/027A61D7/00A61D1/00
CPCA01K67/027A01K2207/20A61D1/00A61D7/00A61K31/195A61K31/4418A61K49/0008A61K2300/00
Inventor 王丽娟高玉元唐红梅张玉虎聂坤马桂贤代成波张雄王丽敏冯淑君郭曼莉
Owner GUANGDONG GENERAL HOSPITAL
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