Method for preparing PLGA (poly lactate glycollic acid)-magnesium mixture and method for manufacturing implant of orthopedics department
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A mixture, plant technology, applied in medical science, tissue regeneration, prosthesis, etc.
Inactive Publication Date: 2017-05-10
THE THIRD HOSPITAL OF HEBEI MEDICAL UNIV
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At present, there is no precedent for making orthopedic implants (internal fixation or filling) by uniformly mixing polylactic acid-glycolic acid copolymer, a biopolymer material, with high-purity magnesium powder. If this method can be realized, it will be The implementation of orthopedic internal fixation materials and internal fixation technology opens up a new road, which is of great significance
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[0044] The method for preparing PLGA-magnesium mixture of the present invention, it adopts the following steps to carry out:
[0045] (1) Determine the total weight of the prepared PLGA-magnesium mixture as m, wherein the magnesium content is n% of the total weight;
[0046] (2) Weigh m×(100-n)% PLGA, and at the same time weigh m×n% high-purity magnesium powder with a purity of more than 99.9% for use;
[0047] (3) Add 12-20 times the weight of chloroform into the container holding the PLGA, and stir with a mixer to make the PLGA fully dissolve in the chloroform;
[0048] (4) Let the mixture stand, and when the chloroform volatilizes and the mixture becomes dense, add the weighed magnesium powder, stir well to make it evenly mixed;
[0049] (5) Place the mixed viscous mixture on the sample plate for air drying;
[0050] (6) The obtained sample was dried in a vacuum oven to obtain a PLGA-magnesium mixture product containing n% magnesium by weight.
[0051] In the above metho...
Embodiment A
[0084] The first layer contains 1% by weight of magnesium, the second layer contains 5% by weight of magnesium, the third layer contains 10% by weight of magnesium, the fourth layer contains 5% by weight of magnesium, and the fifth layer contains 5% by weight of magnesium 1%.
Embodiment B
[0086] The first layer contains 2% magnesium by weight, the second layer contains 7% magnesium by weight, the third layer contains 15% magnesium by weight, the fourth layer contains 30% magnesium by weight, and the fifth layer contains magnesium by weight The percentage is 15%, the sixth layer contains 7% by weight of magnesium, and the seventh layer contains 2% by weight of magnesium.
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Abstract
The invention relates to a method for preparing a PLGA (poly lactate glycollic acid)-magnesium mixture and a method for manufacturing an implant of orthopedics department, and belongs to the technical field of manufacturing and application of degradable materials of orthopedics department. The method is characterized in that the method comprises the following steps of adding chloroform into a PLGA container, uniformly stirring, adding weighed magnesium powder, stirring and fully mixing, airing a mixture for 18 to 24h, and drying for 24 to 48h, so as to prepare a solid PLGA-magnesium mixture; melting the PLGA-magnesium mixture with different magnesium contents in percentage by weight, and overlapping into a plate or cylinder shape, so as to manufacture the implant of the orthopedics department. The method has the advantages that by adjusting the proportional ratio of PLGA and magnesium powder, the acid and alkaline degree, strength, hardness and elastic modulus of a material are controlled, and the biological-mechanical properties of bone are met; the implant of the orthopedics department is matched with skeleton through components with different magnesium contents in percentage by weight, the ideal support and fixing strength or filling effect is provided, and the ideal absorbing and degrading effects are realized.
Description
technical field [0001] The invention relates to a method for preparing a biodegradable material used in orthopedics, and a method for using the material to make an implant, and belongs to the technical field of orthopedics degradable material production and application. Background technique [0002] With the development of the field of bioengineering, the application of biodegradable materials in the medical field has become increasingly mature, and the application of orthopedic internal fixation has also been reported. Compared with traditional orthopedic internal fixation materials, biodegradable materials have better tissue compatibility, and can be degraded after implantation without taking out, avoiding bone defects caused by secondary surgery and implant removal, especially for Patients with osteoporosis or insufficient bone stock have certain advantages. Among them, polylactic acid-glycolic acid (glycolic acid) copolymer (PLGA) is an important class of biodegradable ...
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