Multi-nozzle module based on 3D (three-dimensional) printing and device and technique for large-scale production of particles

Abstract

The invention discloses a technical method for large-scale production of particles by a multi-nozzle module based on a 3D (three-dimensional) printing technique and application of the technical method. The technical method is characterized in that a single nozzle is of a coaxial annular gap air blowing structure, the middle part is provided with a fluid channel, and the coaxial annular gap is an air channel; on the basis of a two-phase flow cutting principle, liquid-phase liquid is cut by air, and liquid droplet particles are produced; by controlling air and liquid outlet pressures and flow rates, the liquid droplets with different particle sizes can be obtained; the number of nozzles can be designed according to the requirement of droplet output, and liquid and air are uniformly distributed by a distributor, so as to obtain higher droplet production efficiency. The technical method has the advantages that the preparation of 3D printing nozzle modules is simple, the material cost is low, and other complicated mechanical processing methods are not required; the prepared particles are free from the pollution by poisonous matters, such as a continuous phase and surfactants; the technical method is especially suitable for preparing high-viscosity solution and suspension droplets containing insoluble particles, is widely applied to the fields of medical care, petroleum, biology, environment protection and the like, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field of preparing microparticles by a microfluidic chip, in particular to a multi-nozzle module based on 3D printing and its mass particle production technology. Background technique [0002] Functional microparticle materials have important applications in many fields such as bioengineering, catalytic reaction, chemical adsorption and pharmaceutical fields. Ideal spherical particles require a relatively uniform particle size distribution, stable chemical properties, and little harm to the environment and biology. The particle preparation process requires simple and fast, easy to control particle size, low cost, and easy to scale up mass production. However, in traditional preparation methods, such as film dispersion, mechanical stirring, static mixing, colloid mill and ultrasonic dispersion, etc., although large-scale production can be effectively carried out, generally only spherical particles can be obtained, ...

AI Technical Summary

Problems solved by technology

[0005] (1) The shear phase required in microfluidics is usually toxic oils such as n-octane and liquid paraffin, and surfactants such as SP80 need to be added, and the prepared droplets will also be mixed with these toxic substances, so in Not applicable in medical, food, biopharmaceutical fields

[0006] (2) The flow rate ratio of the continuous phase and the dispersed phase in microfluidics is usually 6 to 10 times. When the viscosity of the dispersed phase is high, it is difficult for the micro droplets to form. Even if the flow rate ratio reaches 20 times, it may not be able to form particles. Therefore, There are limitations in the selection of particle materials

[0007] (3) The microfluidic method can only add some soluble reagents to the dispersed phase solution. For some solid particles, it is easy to cause microchannel blockage, and it is not suitable for preparing particles from suspensions.

[0008] (4) The microfluidic method requires an additional shear phase, so an additional syringe pump is required, which is costly, more difficult to control during the operation, and more interference factors

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