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Immunogenic polypeptide capable of simulating staphylococcus aureus LTA epitopes and application of immunogenic polypeptide

A Staphylococcus aureus technology, applied in the field of peptides simulating the lipoteichoic acid epitope of Staphylococcus aureus, can solve the problems of inability to induce effective immune memory and good immune response, etc.

Active Publication Date: 2017-05-10
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this molecule is not routinely used as a vaccine candidate, because lipoteichoic acid is a glycolipid component and belongs to thymus-independent antigens. Simply using this molecule as a vaccine cannot induce effective immune memory and a good immune response

Method used

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  • Immunogenic polypeptide capable of simulating staphylococcus aureus LTA epitopes and application of immunogenic polypeptide
  • Immunogenic polypeptide capable of simulating staphylococcus aureus LTA epitopes and application of immunogenic polypeptide
  • Immunogenic polypeptide capable of simulating staphylococcus aureus LTA epitopes and application of immunogenic polypeptide

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Experimental program
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Embodiment Construction

[0041] A polypeptide simulating lipoteichoic acid epitope of Staphylococcus aureus, the core amino acid sequence of which is VHWDFRQWWQPS or GHWDFRQWWQPS.

[0042] Optionally, at least one end of the polypeptide sequence is connected with a protective peptide of no more than 5 amino acids. More preferably, no more than 4 amino acids are connected. The role of the protective peptide is to better maintain the stability of the core polypeptide and prevent its structure from being damaged and invalidated. At the same time, the existence of the protective peptide is also beneficial for coupling the core peptide to other haptens to improve its immunogenicity.

[0043] Further, two amino acids HS are connected to the N-terminal of the core amino acid sequence of the polypeptide.

[0044] Further, GGGS is connected to the C-terminus of the core amino acid sequence of the polypeptide.

[0045] Further, the polypeptide sequence is HSVHWDFRQWWQPSGGGS or HSGHWDFRQWWQPSGGGS.

[0046] A...

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Abstract

The invention discloses an immunogenic polypeptide capable of simulating staphylococcus aureus LTA epitopes and application of the immunogenic polypeptide. A core amino acid sequence of the polypeptide is VHWDFRQWWQPS or GHWDFRQWWQPS. The polypeptide has the advantages that the polypeptide is good in antigenicity and capable of specifically binding with monoclonal antibodies targeting at lipoteichoic acids of multiple kinds of gram-positive bacteria, thereby being capable of well simulating conserved epitopes of the lipoteichoic acids; immunogen immunized mice synthesized by the polypeptide can be induced to resist systemic infection of Staphylococcus aureus and is hopefully developed into a novel protective vaccine and a diagnostic reagent of the Staphylococcus aureus.

Description

technical field [0001] The invention relates to a polypeptide and its application, in particular to a polypeptide simulating the lipoteichoic acid epitope of Staphylococcus aureus. Background technique [0002] Staphylococcus aureus ( S. aureus ) is a Gram-positive bacterium that inhabits human skin and mucous membranes and is the main pathogen of community and nosocomial infections. With the widespread use of antibiotics, the infection rate of Staphylococcus aureus has exceeded 40% in developed countries [1]. In the past decade, the emergence of drug-resistant strains (such as methicillin-resistant, vancomycin-resistant, etc.) According to the monitoring results of CHINET bacterial resistance in my country in 2010, the average detection rate of methicillin-resistant strains in Staphylococcus aureus was as high as 45.2% [2]. In response to the above challenges, people place hope on immunological prevention and treatment of Staphylococcus aureus infection, but so far none of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/31A61K39/085A61P31/04G01N33/569G01N33/68
CPCA61K39/085C07K14/31G01N33/56938G01N33/68G01N2333/31
Inventor 刘北一朱平侯晓睿富宁王湘豫
Owner SOUTHERN MEDICAL UNIVERSITY
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